Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer
暂无分享,去创建一个
S. Kesari | I. Babic | Elmar Nurmemmedov | Pengfei Jiang | V. Yenugonda | A. Cheltsov | N. Her | J. Roper | Rajesh Mukthavaram | Natsuko Nomura
[1] Han N. Lim,et al. EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms , 2018, Scientific Reports.
[2] S. Kesari,et al. Wnt pathway: a hallmark of drug discovery challenge. , 2018, Future medicinal chemistry.
[3] K. Cadigan. Faculty of 1000 evaluation for Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. , 2017 .
[4] Sam W. Lee,et al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. , 2016, Cell reports.
[5] R. Nusse,et al. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control , 2014, Science.
[6] Michael Kahn,et al. Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.
[7] D. Braun,et al. Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions. , 2013, Methods.
[8] J. M. García-Martínez,et al. Glucose-induced β-catenin acetylation enhances Wnt signaling in cancer. , 2013, Molecular cell.
[9] B. R. Bowman,et al. Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin , 2012, Proceedings of the National Academy of Sciences.
[10] A. Strongin,et al. Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase , 2012, PloS one.
[11] S. Weiss,et al. Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity , 2012, Proceedings of the National Academy of Sciences.
[12] Hans Clevers,et al. Wnt/β-Catenin Signaling and Disease , 2012, Cell.
[13] A. Strongin,et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. , 2012, Cancer research.
[14] J. Behrens,et al. A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation , 2012, PloS one.
[15] K. Aldape,et al. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation , 2011, Nature.
[16] Hans Clevers,et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. , 2011, Gastroenterology.
[17] Hans Clevers,et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling , 2011, Nature.
[18] R. Dasgupta,et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway , 2011, Proceedings of the National Academy of Sciences.
[19] A. Strongin,et al. Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase. , 2011, Assay and drug development technologies.
[20] S. Ivy,et al. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways , 2011, Nature Reviews Clinical Oncology.
[21] Bruce J. Melancon,et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. , 2010, Nature chemical biology.
[22] Marc W. Kirschner,et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.
[23] Xi He,et al. Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.
[24] Hans Clevers,et al. Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.
[25] W. Birchmeier,et al. Wnt signalling and its impact on development and cancer , 2008, Nature Reviews Cancer.
[26] R. Nusse,et al. Wnt signaling and stem cell control , 2008, Cell Research.
[27] Gordon B. Mills,et al. Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity* , 2007, Journal of Biological Chemistry.
[28] A. C. Williams,et al. Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia , 2007, Nature Cell Biology.
[29] W. Weis,et al. Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. , 2006, The Journal of biological chemistry.
[30] W. Bodmer,et al. Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis. , 2002, British medical bulletin.
[31] P. Vogt,et al. Oncogenic transformation by β-catenin: deletion analysis and characterization of selected target genes , 2002, Oncogene.
[32] Michael J. Eck,et al. Structure of a human Tcf4–β-catenin complex , 2001, Nature Structural Biology.
[33] Lawrence Shapiro,et al. β-catenin and its multiple partners: promiscuity explained , 2001, Nature Structural Biology.
[34] A. Ben-Ze'ev,et al. Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. , 2000, Journal of cell science.
[35] J Straub,et al. APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[36] Yusuke Nakamura,et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.
[37] W. Birchmeier,et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. , 1998, Science.
[38] K. Kinzler,et al. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.
[39] Hans Clevers,et al. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC , 1997, Science.
[40] Paul Polakis,et al. Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines , 1997, Science.
[41] W. L. Jorgensen,et al. Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids , 1996 .
[42] Harold E. Varmus,et al. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.
[43] A. C. Williams,et al. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. , 2007, Nature cell biology.
[44] L. Shapiro,et al. beta-catenin and its multiple partners: promiscuity explained. , 2001, Nature structural biology.
[45] P. Robbins,et al. Stabilization of beta-catenin by genetic defects in melanoma cell lines. , 1997, Science.