Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
暂无分享,去创建一个
F. Wang | E. A. Reece | Peixin Yang | Xuezheng Li | Cheng Xu | C. Harman | Jianxiang Zhong | Yanqing Wu | Daoyin Dong | Jingwen Yu | Penghua Yang | Cheng Wang
[1] Peixin Yang,et al. Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy. , 2016, Free radical biology & medicine.
[2] Peixin Yang,et al. High glucose‐induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects , 2016, Journal of neurochemistry.
[3] C. Kappen,et al. Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain , 2015, Scientific Reports.
[4] F. Wang,et al. Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy. , 2015, American journal of obstetrics and gynecology.
[5] F. Wang,et al. Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis. , 2015, American journal of obstetrics and gynecology.
[6] F. Wang,et al. Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. , 2015, American journal of obstetrics and gynecology.
[7] Peixin Yang,et al. The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.
[8] M. Quon,et al. Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy , 2015, Diabetes.
[9] Duchen,et al. PPAR gamma and PGC-1 alpha as Therapeutic Targets in Parkinson's , 2015 .
[10] S. Fang,et al. Ask1 Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome , 2014, Diabetes.
[11] M. Duchen,et al. PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s , 2014, Neurochemical Research.
[12] B. Bay,et al. Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). , 2014, The Journal of Biological Chemistry.
[13] P. Codogno. Shining light on autophagy , 2014, Nature Reviews Molecular Cell Biology.
[14] R. Xavier,et al. Autophagy is essential for cardiac morphogenesis during vertebrate development , 2014, Autophagy.
[15] Zhen Yan,et al. Autophagy is required for exercise training‐induced skeletal muscle adaptation and improvement of physical performance , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[16] F. Wang,et al. Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis. , 2013, American journal of physiology. Endocrinology and metabolism.
[17] H. R. Zielke,et al. Maternal Hyperglycemia Activates an ASK1–FoxO3a–Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects , 2013, Science Signaling.
[18] B. Tirosh,et al. Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes , 2013, Diabetes.
[19] Peixin Yang,et al. c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy , 2013, Diabetes.
[20] K. Das,et al. Protein kinase C, an elusive therapeutic target? , 2012, Nature Reviews Drug Discovery.
[21] Julie St-Pierre,et al. PGC1&agr; and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders , 2012, Journal of Cell Science.
[22] N. Greene,et al. Epithelial fusion during neural tube morphogenesis. , 2012, Birth defects research. Part A, Clinical and molecular teratology.
[23] Hui Gu,et al. Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects , 2012, Journal of neurochemistry.
[24] E. A. Reece,et al. Oxidative Stress–Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy , 2012, Diabetes.
[25] G. Ning,et al. Peri‐implantation lethality in mice lacking the PGC‐1‐related coactivator protein , 2012, Developmental dynamics : an official publication of the American Association of Anatomists.
[26] D. DiPette,et al. Resveratrol Prevents Impairment in Activation of Retinoic Acid Receptors and MAP Kinases in the Embryos of a Rodent Model of Diabetic Embryopathy , 2012, Reproductive Sciences.
[27] M. Pisano,et al. MicroRNA gene expression signatures in the developing neural tube. , 2011, Birth defects research. Part A, Clinical and molecular teratology.
[28] E. A. Reece,et al. SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy. , 2011, American journal of obstetrics and gynecology.
[29] E. A. Reece,et al. Protein kinase Cβ2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway. , 2011, American journal of obstetrics and gynecology.
[30] E. Ralston,et al. Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle , 2010, PloS one.
[31] J. Simpson,et al. Myocardial Infarction and Risk of Suicide: A Population-Based Case-Control Study , 2010, Circulation.
[32] N. Mizushima,et al. Autophagy in mammalian development and differentiation , 2010, Nature Cell Biology.
[33] Deepak Srinivasan,et al. Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. , 2010, Human molecular genetics.
[34] C. Kappen,et al. Neural tube defect genes and maternal diabetes during pregnancy. , 2010, Birth defects research. Part A, Clinical and molecular teratology.
[35] Ruzhu Chen,et al. Down‐expression of PGC‐1α partially mediated by JNK/c‐Jun through binding to CRE site during apoptotic procedure in cerebellar granule neurons , 2010, Journal of neuroscience research.
[36] J. Yodoi,et al. Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy , 2010, Diabetologia.
[37] Wenhua Liu,et al. Protein kinase C inhibits autophagy and phosphorylates LC3. , 2010, Biochemical and biophysical research communications.
[38] C. Chou,et al. PKCα mediated induction of miR-101 in human hepatoma HepG2 cells , 2010, Journal of Biomedical Science.
[39] H. Pilegaard,et al. The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. , 2009, American journal of physiology. Cell physiology.
[40] Yun Xu,et al. NMDA Receptor Dependent PGC-1α Up-Regulation Protects the Cortical Neuron Against Oxygen-Glucose Deprivation/Reperfusion Injury , 2009, Journal of Molecular Neuroscience.
[41] S. Hayasaka,et al. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes , 2009, Diabetologia.
[42] A. J. Copp. Neural Tube Defects , 2008 .
[43] Lilah M. Besser,et al. Diabetes mellitus and birth defects. , 2008, American journal of obstetrics and gynecology.
[44] M. Murakami,et al. Autophagy Is Essential for Preimplantation Development of Mouse Embryos , 2008, Science.
[45] E. A. Reece,et al. Demonstration of the Essential Role of Protein Kinase C Isoforms in Hyperglycemia-Induced Embryonic Malformations , 2008, Reproductive Sciences.
[46] L. Groop,et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion , 2008, Diabetologia.
[47] Guido Kroemer,et al. Autophagy in the Pathogenesis of Disease , 2008, Cell.
[48] P. Walter,et al. Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.
[49] Peter Schwartz,et al. Ambra1 regulates autophagy and development of the nervous system , 2007, Nature.
[50] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[51] Jiandie D. Lin,et al. Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice , 2004, Cell.
[52] T. Hewett,et al. PKC-α regulates cardiac contractility and propensity toward heart failure , 2004, Nature Medicine.
[53] M. Matsui,et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. , 2003, Molecular biology of the cell.
[54] Arnold J. Levine,et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[55] P. Puigserver,et al. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.
[56] Y. Jan,et al. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis , 2002, Nature.
[57] V. Mootha,et al. Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.
[58] U. Eriksson,et al. Altered mitochondrial morphology of rat embryos in diabetic pregnancy , 1995, The Anatomical record.
[59] M. Gurney,et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.
[60] R. McKay,et al. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors , 1994, Neuron.
[61] V. Ambros,et al. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.
[62] J. Cordero,et al. Maternal diabetes: The risk for specific birth defects , 1992, European Journal of Epidemiology.
[63] C. Cepko,et al. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum , 1992, Cell.
[64] M. Khoury,et al. Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study. , 1990, Pediatrics.
[65] E. A. Reece,et al. Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy. , 2008, American journal of obstetrics and gynecology.
[66] T. Hewett,et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. , 2004, Nature medicine.