IDENTIFICATION AND CHEMICAL SYNTHESIS OF MDL 105,212, A NON-PEPTIDE TACHYKININ ANTAGONIST WITH HIGH AFFINITY FOR NK1 AND NK2 RECEPTORS

[1]  P. Sterk,et al.  Effects of inhaled substance P on airway responsiveness to methacholine in asthmatic subjects in vivo. , 1994, Journal of applied physiology.

[2]  E. Kudlacz,et al.  Tachykinin-mediated respiratory effects in conscious guinea pigs: modulation by NK1 and NK2 receptor antagonists. , 1993, European journal of pharmacology.

[3]  G. Fur,et al.  Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor , 1993 .

[4]  C. Maggi,et al.  Tachykinin receptors and airway pathophysiology. , 1993, The European respiratory journal.

[5]  C. Maggi,et al.  Tachykinin receptors and tachykinin receptor antagonists. , 1993, Journal of autonomic pharmacology.

[6]  J. Lowe,et al.  The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst. , 1992, Journal of medicinal chemistry.

[7]  E. Naline,et al.  A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. , 1992, Life sciences.

[8]  J. Solway,et al.  Sensory neuropeptides and airway function. , 1991, Journal of applied physiology.

[9]  P. Barnes Neuropeptides and asthma. , 1991, The American review of respiratory disease.

[10]  J. Lowe,et al.  A potent nonpeptide antagonist of the substance P (NK1) receptor. , 1991, Science.

[11]  C. Maggi,et al.  Tachykinin receptors in the airways and lung: what should be block? , 1990, Pharmacological research.

[12]  P. Barnes,et al.  Modulation of neurogenic inflammation: novel approaches to inflammatory disease. , 1990, Trends in pharmacological sciences.

[13]  P. Barnes ASTHMA AS AN AXON REFLEX , 1986, The Lancet.

[14]  Z. Šedivý,et al.  1-Aryl- and 1-(arylmethyl)-4-guanylpiperazines and other heterocyclic and alicyclic guanidine derivatives , 1975 .

[15]  H. Brown,et al.  Selective reductions. XII. Explorations in some representative applications of aluminum hydride for selective reductions , 1968 .

[16]  J. C. Sheehan,et al.  Notes- A Convenient Synthesis of Water-Soluble Carbodiimides. , 1961 .

[17]  P. Rabe Über die Reduktion der China‐Ketone zu China‐Alkoholen und über die sterische Umlagerung von China‐Alkaloiden. Stereochemische Forschungen. II , 1932 .