Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy

Propylene glycol alginate sodium sulfate (PSS) is poorly absorbed by oral administration due to its large molecular weight and slightly degradability in stomach acidic environment. Here, a novel enteric‐coated nano formulation of PSS (enteric PSS‐NP) was prepared to improve its bioavailability and efficacy.

[1]  Dongwon Lee,et al.  Acid‐activatable oxidative stress‐inducing polysaccharide nanoparticles for anticancer therapy , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[2]  Bin Wang,et al.  Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method. , 2013, Colloids and surfaces. B, Biointerfaces.

[3]  H. Guan,et al.  An HPLC Method for Microanalysis and Pharmacokinetics of Marine Sulfated Polysaccharide PSS-Loaded Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles in Rat Plasma , 2013, Marine drugs.

[4]  Jin Han,et al.  Development and in vivo/in vitro evaluation of novel herpetrione nanosuspension. , 2013, International journal of pharmaceutics.

[5]  Qiang Zhang,et al.  pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[6]  Zibin Gao,et al.  Nanotechnology applied to overcome tumor drug resistance. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[7]  F. Gao,et al.  Preparation, characterization and pharmacokinetic studies of tacrolimus-dimethyl-β-cyclodextrin inclusion complex-loaded albumin nanoparticles. , 2012, International journal of pharmaceutics.

[8]  Xuenong Zhang,et al.  The Modelling Pharmacokinetic Profile of Freeze-Dried Cyclosporine A-Eudragit S100 Nanoparticle Formulation in Dogs , 2012 .

[9]  L. Chun.  Progress of marine drug propylene glycol alginate sodium sulfate (PSS) and inspiration , 2012 .

[10]  Hsing-Wen Sung,et al.  A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. , 2011, Biomaterials.

[11]  Jianjun Zhang,et al.  Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. , 2011, International journal of pharmaceutics.

[12]  Shilei Hao,et al.  Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid , 2011 .

[13]  Hirofumi Takeuchi,et al.  Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[14]  Guan Hua-shi.  Study on preparation,release in vitro and pharmacodynamics of the oral propylene glycol alginate sodium sulfate(PSS) nanoparticles , 2011 .

[15]  K. Dorfman,et al.  Giant biocompatible and biodegradable PEG-PMCL vesicles and microcapsules by solvent evaporation from double emulsion droplets. , 2010, Journal of colloid and interface science.

[16]  A. Lamprecht,et al.  Colonic delivery of carboxyfluorescein by pH-sensitive microspheres in experimental colitis. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[17]  Yong Zhang,et al.  PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel , 2010, Comput. Methods Programs Biomed..

[18]  Hsin‐Lung Chen,et al.  Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. , 2010, Biomaterials.

[19]  Peter York,et al.  Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. , 2009, International journal of pharmaceutics.

[20]  M. Kraume,et al.  Crystallized miniemulsions: Influence of operating parameters during high-pressure homogenization on size and shape of particles , 2008 .

[21]  Chi H. Lee,et al.  Development of chitosan-SLN microparticles for chemotherapy: in vitro approach through efflux-transporter modulation. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Wang Yi.  Study on preparation and releasing characteristics of Cyclosporin A pH sensitive nanoparticles in vitro , 2008 .

[23]  S. McCall,et al.  Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.

[24]  J. Xu,et al.  Effect of WOW process parameters on morphology and burst release of FITC-dextran loaded PLGA microspheres. , 2007, International journal of pharmaceutics.

[25]  Z. Su,et al.  Influence of process parameters on the size distribution of PLA microcapsules prepared by combining membrane emulsification technique and double emulsion-solvent evaporation method. , 2005, Colloids and surfaces. B, Biointerfaces.

[26]  Stephen B. Duffull,et al.  Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel® , 2005, Comput. Biol. Medicine.

[27]  Raviraj M. Kulkarni,et al.  Nanosuspensions: a promising drug delivery strategy , 2004, The Journal of pharmacy and pharmacology.

[28]  J. Swarbrick,et al.  Albumin Microspheres as a Drug Delivery System: Relation Among Turbidity Ratio, Degree of Cross-linking, and Drug Release , 1993, Pharmaceutical Research.

[29]  T. Kissel,et al.  Brush-like branched biodegradable polyesters, part III. Protein release from microspheres of poly(vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid). , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[30]  G. P. Martin,et al.  Preparation of hydrophobic and hydrophilic albumin microspheres and determination of surface carboxylic acid and amino residues , 1997 .

[31]  D. Coleman,et al.  Laboratory animals exhibiting obesity and diabetes syndromes. , 1977, Metabolism: clinical and experimental.