Transcription-independent pro-apoptotic functions of p53.

[1]  M. Mattson,et al.  p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults , 2007, NeuroMolecular Medicine.

[2]  W. Deppert,et al.  Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress , 2006, Oncogene.

[3]  S. Fulda,et al.  Apoptosis and cancer therapy : from cutting-edge science to novel therapeutic concepts , 2006 .

[4]  Pankaj Oberoi,et al.  Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. , 2005, Cancer cell.

[5]  M. Nakao,et al.  Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria* , 2005, Journal of Biological Chemistry.

[6]  N. Colburn,et al.  p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. , 2005, Cancer research.

[7]  D. Green,et al.  Transcription, apoptosis and p53: catch-22. , 2005, Trends in genetics : TIG.

[8]  U. Moll,et al.  The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria , 2005, Cell Death and Differentiation.

[9]  Y. Yoo,et al.  Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis , 2005, Apoptosis.

[10]  M. Protopopova,et al.  Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors , 2004, Nature Medicine.

[11]  H. Yamaguchi,et al.  Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways* , 2004, Journal of Biological Chemistry.

[12]  M. Memo,et al.  The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death , 2004, Cell Death and Differentiation.

[13]  U. Moll,et al.  In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation , 2004, Molecular and Cellular Biology.

[14]  Patrick Dumont,et al.  Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex , 2004, Nature Cell Biology.

[15]  A. Gunasekera,et al.  Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR , 2004, FEBS letters.

[16]  Martin Schuler,et al.  Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis , 2004, Science.

[17]  L. Vassilev,et al.  In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.

[18]  M. Ciotti,et al.  Oxidative stress induces p53‐mediated apoptosis in glia: p53 transcription‐independent way to die , 2004, Journal of neuroscience research.

[19]  Muyang Li,et al.  Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2 , 2003, Science.

[20]  S. Lowe,et al.  Control of apoptosis by p53 , 2003, Oncogene.

[21]  D. Green,et al.  Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. , 2003, Cancer cell.

[22]  Luca Scorrano,et al.  Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. , 2003, Biochemical and biophysical research communications.

[23]  C. Dive,et al.  Mitochondrial membrane permeabilisation by Bax/Bak. , 2003, Biochemical and biophysical research communications.

[24]  Petr Pancoska,et al.  p53 has a direct apoptogenic role at the mitochondria. , 2003, Molecular cell.

[25]  M. Murphy,et al.  The codon 72 polymorphic variants of p53 have markedly different apoptotic potential , 2003, Nature Genetics.

[26]  M. Oren,et al.  The p53-Mdm2 module and the ubiquitin system. , 2003, Seminars in cancer biology.

[27]  P. Dagher,et al.  P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. , 2003, Journal of the American Society of Nephrology : JASN.

[28]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[29]  U. Moll,et al.  Hypoxia death stimulus induces translocation of p53 protein to mitochondria , 2001, FEBS letters.

[30]  A. Levine,et al.  Surfing the p53 network , 2000, Nature.

[31]  Mark P. Mattson,et al.  Apoptosis in neurodegenerative disorders , 2000, Nature Reviews Molecular Cell Biology.

[32]  N D Marchenko,et al.  Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.

[33]  D. Green,et al.  p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release* , 2000, The Journal of Biological Chemistry.

[34]  J. Levine,et al.  Surfing the p53 network , 2000, Nature.

[35]  W. Deppert,et al.  Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53 , 1999, Oncogene.

[36]  A. Balmain,et al.  The p53 response to ionising radiation in adult and developing murine tissues. , 1996, Oncogene.

[37]  X. Chen,et al.  p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. , 1996, Genes & development.

[38]  E. Shaulian,et al.  Induction of apoptosis in HeLa cells by trans-activation-deficient p53. , 1995, Genes & development.

[39]  D. Lane,et al.  Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. , 1995, Journal of cell science.

[40]  N. Hay,et al.  Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.

[41]  M. Karin,et al.  p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes , 1994, Nature.

[42]  W. Bursch Apoptosis and Cancer Therapy , 1994 .

[43]  D. Lane,et al.  p53, guardian of the genome , 1992, Nature.

[44]  D. Lane,et al.  Cancer. p53, guardian of the genome. , 1992, Nature.