Transcription-independent pro-apoptotic functions of p53.
暂无分享,去创建一个
[1] M. Mattson,et al. p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults , 2007, NeuroMolecular Medicine.
[2] W. Deppert,et al. Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress , 2006, Oncogene.
[3] S. Fulda,et al. Apoptosis and cancer therapy : from cutting-edge science to novel therapeutic concepts , 2006 .
[4] Pankaj Oberoi,et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. , 2005, Cancer cell.
[5] M. Nakao,et al. Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria* , 2005, Journal of Biological Chemistry.
[6] N. Colburn,et al. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. , 2005, Cancer research.
[7] D. Green,et al. Transcription, apoptosis and p53: catch-22. , 2005, Trends in genetics : TIG.
[8] U. Moll,et al. The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria , 2005, Cell Death and Differentiation.
[9] Y. Yoo,et al. Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis , 2005, Apoptosis.
[10] M. Protopopova,et al. Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors , 2004, Nature Medicine.
[11] H. Yamaguchi,et al. Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways* , 2004, Journal of Biological Chemistry.
[12] M. Memo,et al. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death , 2004, Cell Death and Differentiation.
[13] U. Moll,et al. In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation , 2004, Molecular and Cellular Biology.
[14] Patrick Dumont,et al. Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex , 2004, Nature Cell Biology.
[15] A. Gunasekera,et al. Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR , 2004, FEBS letters.
[16] Martin Schuler,et al. Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis , 2004, Science.
[17] L. Vassilev,et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.
[18] M. Ciotti,et al. Oxidative stress induces p53‐mediated apoptosis in glia: p53 transcription‐independent way to die , 2004, Journal of neuroscience research.
[19] Muyang Li,et al. Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2 , 2003, Science.
[20] S. Lowe,et al. Control of apoptosis by p53 , 2003, Oncogene.
[21] D. Green,et al. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. , 2003, Cancer cell.
[22] Luca Scorrano,et al. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. , 2003, Biochemical and biophysical research communications.
[23] C. Dive,et al. Mitochondrial membrane permeabilisation by Bax/Bak. , 2003, Biochemical and biophysical research communications.
[24] Petr Pancoska,et al. p53 has a direct apoptogenic role at the mitochondria. , 2003, Molecular cell.
[25] M. Murphy,et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential , 2003, Nature Genetics.
[26] M. Oren,et al. The p53-Mdm2 module and the ubiquitin system. , 2003, Seminars in cancer biology.
[27] P. Dagher,et al. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. , 2003, Journal of the American Society of Nephrology : JASN.
[28] Xin Lu,et al. Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.
[29] U. Moll,et al. Hypoxia death stimulus induces translocation of p53 protein to mitochondria , 2001, FEBS letters.
[30] A. Levine,et al. Surfing the p53 network , 2000, Nature.
[31] Mark P. Mattson,et al. Apoptosis in neurodegenerative disorders , 2000, Nature Reviews Molecular Cell Biology.
[32] N D Marchenko,et al. Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.
[33] D. Green,et al. p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release* , 2000, The Journal of Biological Chemistry.
[34] J. Levine,et al. Surfing the p53 network , 2000, Nature.
[35] W. Deppert,et al. Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53 , 1999, Oncogene.
[36] A. Balmain,et al. The p53 response to ionising radiation in adult and developing murine tissues. , 1996, Oncogene.
[37] X. Chen,et al. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. , 1996, Genes & development.
[38] E. Shaulian,et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. , 1995, Genes & development.
[39] D. Lane,et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. , 1995, Journal of cell science.
[40] N. Hay,et al. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.
[41] M. Karin,et al. p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes , 1994, Nature.
[42] W. Bursch. Apoptosis and Cancer Therapy , 1994 .
[43] D. Lane,et al. p53, guardian of the genome , 1992, Nature.
[44] D. Lane,et al. Cancer. p53, guardian of the genome. , 1992, Nature.