Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions Part II: Ventricular arrhythmias, channelopathies and implantable defibrillators

This consensus paper on behalf of the Study Group on Sports Cardiology of the European Society of Cardiology follows a previous one on guidelines for sports participation in competitive and recreational athletes with supraventricular arrhythmias and pacemakers. The question of imminent life-threatening arrhythmias is especially relevant when some form of ventricular rhythm disorder is documented, or when the patient is diagnosed to have inherited a pro-arrhythmogenic disorder. Frequent ventricular premature beats or nonsustained ventricular tachycardia may be a hallmark of underlying pathology and increased risk. Their finding should prompt a thorough cardiac evaluation, including both imaging modalities and electrophysiological techniques. This should allow distinguishing idiopathic rhythm disorders from underlying disease that carries a more ominous prognosis. Recommendations on sports participation in inherited arrhythmogenic conditions and asymptomatic gene carriers are also discussed: congenital and acquired long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy and other familial electrical disease of unknown origin. If an implantable cardioverter defibrillator is indicated, it is no substitute for the guidelines relating to the underlying pathology. Moreover, some particular recommendations for patients/athletes with an implantable cardioverter defibrillator are to be observed.

[1]  B. Merkely,et al.  Clinical Experience with a New Detection Algorithm for Differentiation of Supraventricular from Ventricular Tachycardia in a Dual‐Chamber Defibrillator , 2004, Journal of cardiovascular electrophysiology.

[2]  P. Schwartz,et al.  Electrocardiographic Features in Andersen-Tawil Syndrome Patients With KCNJ2 Mutations: Characteristic T-U–Wave Patterns Predict the KCNJ2 Genotype , 2005, Circulation.

[3]  B. Maron Sudden death in young athletes. , 1980, The New England journal of medicine.

[4]  Prevalence and nature of cardiac arrhythmias in apparently normal well-trained runners. , 1982, American heart journal.

[5]  S. Priori,et al.  Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias , 2000, Journal of cardiovascular electrophysiology.

[6]  B. Maron,et al.  Competitive athletes with cardiovascular disease--the case of Nicholas Knapp. , 1998, The New England journal of medicine.

[7]  D. Corrado,et al.  Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. , 2000, Journal of the American College of Cardiology.

[8]  Harold L. Kennedy,et al.  Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. , 1985, The New England journal of medicine.

[9]  N. Wolfe Electrocardiographic features of arrhythmogenic right ventricular dysplasia/cardiomyopathy according to disease severity: A need to broaden diagnostic criteria , 2005 .

[10]  G. Danieli,et al.  Juvenile sudden death in a family with polymorphic ventricular arrhythmias caused by a novel RyR2 gene mutation: evidence of specific morphological substrates. , 2005, Human pathology.

[11]  C. Antzelevitch,et al.  Chapter 9. ST Segment Elevation and Sudden Death in the Athlete , 2007 .

[12]  G. V. Van Hare,et al.  Task Force 7: arrhythmias. , 2005, Journal of the American College of Cardiology.

[13]  M. Borggrefe,et al.  Clinical characteristics and treatment of short QT syndrome , 2005, Expert review of cardiovascular therapy.

[14]  B. Maron,et al.  Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. , 2002, Journal of the American College of Cardiology.

[15]  D. Wilber,et al.  Ablation of Idiopathic Right Ventricular Outflow Tract Tachycardia: Current Perspectives , 2005, Journal of cardiovascular electrophysiology.

[16]  C. Chiang,et al.  Congenital and Acquired Long QT Syndrome: Current Concepts and Management , 2004, Cardiology in review.

[17]  C. O'Morain,et al.  Current Concepts and Management , 2000 .

[18]  B. Maron,et al.  Introduction: eligibility recommendations for competitive athletes with cardiovascular abnormalities-general considerations. , 2005, Journal of the American College of Cardiology.

[19]  S. Rahimtoola,et al.  Idiopathic paroxysmal ventricular tachycardia with a QRS pattern of right bundle branch block and left axis deviation: a unique clinical entity with specific properties. , 1983, The American journal of cardiology.

[20]  Proposed diagnostic criteria for the Brugada syndrome. , 2002, European heart journal.

[21]  M. Ackerman,et al.  Epinephrine QT Stress Testing in the Evaluation of Congenital Long-QT Syndrome: Diagnostic Accuracy of the Paradoxical QT Response , 2005, Circulation.

[22]  C. Schmitt,et al.  Do Current Dual Chamber Cardioverter Defibrillators Have Advantages Over Conventional Single Chamber Cardioverter Defibrillators in Reducing Inappropriate Therapies? A Randomized, Prospective Study , 2001, Journal of cardiovascular electrophysiology.

[23]  D. Corrado,et al.  Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases. , 1990, The American journal of medicine.

[24]  K Shimomura,et al.  The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. , 1999, European heart journal.

[25]  A. Wilde,et al.  Sudden Unexplained Death: Heritability and Diagnostic Yield of Cardiological and Genetic Examination in Surviving Relatives , 2005, Circulation.

[26]  B. Maron,et al.  Clinical significance of abnormal electrocardiographic patterns in trained athletes. , 2000, Circulation.

[27]  R. Bonow,et al.  36th Bethesda Conference: Eligibility Recommendations for Competitive Athletes With Cardiovascular Abnormalities , 2005 .

[28]  X. Jouven,et al.  Natural History and Risk Stratification of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy , 2004, Circulation.

[29]  Wojciech Zareba,et al.  Long QT Syndrome. , 1992, Current problems in cardiology.

[30]  C. Antzelevitch In vivo human demonstration of phase 2 reentry. , 2005, Heart rhythm.

[31]  R. Liberthson,et al.  Sudden death from cardiac causes in children and young adults. , 1996, The New England journal of medicine.

[32]  B. Maron,et al.  Impact of physical deconditioning on ventricular tachyarrhythmias in trained athletes. , 2004, Journal of the American College of Cardiology.

[33]  D. Corrado,et al.  Screening for hypertrophic cardiomyopathy in young athletes. , 1998, The New England journal of medicine.

[34]  D. Cannom,et al.  Safety of Sports Participation in Patients with Implantable Cardioverter Defibrillators: 
A Survey of Heart Rhythm Society Members , 2006, Journal of cardiovascular electrophysiology.

[35]  C. Wren Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. , 2005, European heart journal.

[36]  T. Ryan,et al.  Electrocardiogram of the athlete: an analysis of 289 professional football players. , 1984, The American journal of cardiology.

[37]  E. Prystowsky,et al.  Clinical and electrophysiologic findings in patients with repetitive monomorphic ventricular tachycardia and otherwise normal electrocardiogram. , 1982, The American journal of cardiology.

[38]  M. Brodsky,et al.  Life-threatening ventricular arrhythmias due to transient or correctable causes: high risk for death in follow-up. , 2001, Journal of the American College of Cardiology.

[39]  Michael J Ackerman,et al.  Spectrum and prevalence of cardiac ryanodine receptor (RyR2) mutations in a cohort of unrelated patients referred explicitly for long QT syndrome genetic testing. , 2005, Heart rhythm.

[40]  M. Josephson,et al.  Repetitive, monomorphic ventricular tachycardia: clinical and electrophysiologic characteristics in patients with and patients without organic heart disease. , 1984, The American journal of cardiology.

[41]  Maurizio Schiavon,et al.  Does sports activity enhance the risk of sudden death in adolescents and young adults? , 2003, Journal of the American College of Cardiology.

[42]  H. Heidbuchel,et al.  High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification. , 2003, European heart journal.

[43]  S. Globits,et al.  Significance of morphological abnormalities detected by MRI in patients undergoing successful ablation of right ventricular outflow tract tachycardia. , 1997, Circulation.

[44]  W. Haskell,et al.  Task Force 8: classification of sports. , 2005, Journal of the American College of Cardiology.

[45]  A. Angelini,et al.  Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis? , 1996, Circulation.

[46]  S. Laniado,et al.  Response of recurrent sustained ventricular tachycardia to verapamil. , 1981, British heart journal.

[47]  Michael J Ackerman,et al.  Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases. , 2004, Circulation.

[48]  A. Nava,et al.  Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology. , 1994, British heart journal.

[49]  Calum A MacRae,et al.  Risk stratification in the long-QT syndrome. , 2003, The New England journal of medicine.

[50]  Peter J. Schwartz,et al.  Diagnostic Criteria for the Long QT Syndrome An Update , 1993, Circulation.

[51]  P. Carmeliet,et al.  Novel pore mutation in SCN5A manifests as a spectrum of phenotypes ranging from atrial flutter, conduction disease, and Brugada syndrome to sudden cardiac death. , 2004, Heart rhythm.

[52]  I. Carrió,et al.  Marked ventricular repolarization abnormalities in highly trained athletes' electrocardiograms: clinical and prognostic implications. , 2000, Journal of the American College of Cardiology.

[53]  A. Camm,et al.  Congenital and acquired long QT syndrome. , 2000, European heart journal.

[54]  Martin Borggrefe,et al.  Short QT Syndrome: A Familial Cause of Sudden Death , 2003, Circulation.

[55]  Wataru Shimizu,et al.  Brugada syndrome: report of the second consensus conference. , 2005, Heart rhythm.

[56]  A. Russo,et al.  Idiopathic fascicular left ventricular tachycardia: linear ablation lesion strategy for noninducible or nonsustained tachycardia. , 2005, Heart rhythm.

[57]  J. Brugada,et al.  Idiopathic Short QT Interval:A New Clinical Syndrome? , 2001, Cardiology.

[58]  C. Kanakis,et al.  Twenty-four hour continuous ECG recordings in long-distance runners. , 1982, Chest.

[59]  E. Michelson,et al.  Polymorphous ventricular tachycardia associated with normal and long Q-T intervals. , 1982, The American journal of cardiology.

[60]  G Thiene,et al.  The gene for arrhythmogenic right ventricular cardiomyopathy maps to chromosome 14q23-q24. , 1994, Human molecular genetics.

[61]  R. Fagard,et al.  Effect of exercise training in patients with an implantable cardioverter defibrillator. , 2004, European heart journal.

[62]  S. Peters,et al.  Risk factors of cardiac arrest in arrhythmogenic right ventricular dysplasia. , 1995, European heart journal.

[63]  H. Bjørnstad,et al.  Ambulatory electrocardiographic findings in top athletes, athletic students and control subjects. , 1994, Cardiology.

[64]  S. B. Haefele,et al.  Recommendations for Participation in Competitive Sports. , 1988, The Physician and sportsmedicine.

[65]  M. Link,et al.  Report of the NASPE Policy Conference on Arrhythmias and the Athlete , 2001, Journal of cardiovascular electrophysiology.

[66]  J. Brugada,et al.  The Brugada Syndrome: From Bench to Bedside , 2005 .

[67]  L. Jordaens,et al.  Comparison of athletes with life-threatening ventricular arrhythmias with two groups of healthy athletes and a group of normal control subjects. , 1994, The American journal of cardiology.

[68]  W. Mckenna,et al.  Electrocardiographic changes in 1000 highly trained junior elite athletes. , 1999, British journal of sports medicine.

[69]  P. Palatini,et al.  Prevalence and possible mechanisms of ventricular arrhythmias in athletes. , 1985, American heart journal.

[70]  D. Packer,et al.  Noncontact mapping to guide ablation of right ventricular outflow tract tachycardia. , 2002, Journal of the American College of Cardiology.