Cdk5 deregulation in the pathogenesis of Alzheimer's disease.
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[1] Hiroshi Takahashi,et al. Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain , 2001, Neuroscience Letters.
[2] L. Tsai,et al. Colocalization and Fluorescence Resonance Energy Transfer between cdk5 and AT8 Suggests a Close Association in Pre‐Neurofibrillary Tangles and Neurofibrillary Tangles , 2002, Journal of neuropathology and experimental neurology.
[3] F. Liu,et al. Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5 , 2003, FEBS letters.
[4] J. Julien,et al. Deregulation of Cdk5 in a Mouse Model of ALS Toxicity Alleviated by Perikaryal Neurofilament Inclusions , 2001, Neuron.
[5] Junmin Peng,et al. Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis , 2003, Neuron.
[6] Tony Hunter,et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration , 2003, Nature.
[7] R. Booher,et al. Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic mice , 2002, The Journal of comparative neurology.
[8] L. Tsai,et al. Neurotoxicity induces cleavage of p35 to p25 by calpain , 2000, Nature.
[9] G. Pigino,et al. A novel CDK5‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons , 2004, The EMBO journal.
[10] J. Hardy,et al. The relationship between amyloid and tau , 2003, Journal of Molecular Neuroscience.
[11] Kazuyuki Takata,et al. Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo , 2003, Neuron.
[12] M. Mullan,et al. p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro , 2002, Journal of neuroscience research.
[13] J. Radulovic,et al. Cyclin-Dependent Kinase 5 Is Required for Associative Learning , 2002, The Journal of Neuroscience.
[14] L. Tsai,et al. Structure and Regulation of the CDK5-p25nck5a Complex , 2001 .
[15] R. Maccioni,et al. Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death , 1999, FEBS letters.
[16] Wei Li,et al. Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau* , 2000, The Journal of Biological Chemistry.
[17] Y. Kirino,et al. Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of β-Amyloid* , 2001, The Journal of Biological Chemistry.
[18] A. Kulkarni,et al. Regulation of NMDA receptors by cyclin-dependent kinase-5 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[19] J. Bibb,et al. Developmental Regulation of the Proteolysis of the p35 Cyclin-Dependent Kinase 5 Activator by Phosphorylation , 2003, The Journal of Neuroscience.
[20] Li-Huei Tsai,et al. NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein , 2000, Neuron.
[21] L. Nicholson,et al. Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. , 2001, Journal of molecular biology.
[22] K. Tomizawa,et al. An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*) , 1995, The Journal of Biological Chemistry.
[23] B. Lu,et al. PAR-1 Kinase Plays an Initiator Role in a Temporally Ordered Phosphorylation Process that Confers Tau Toxicity in Drosophila , 2004, Cell.
[24] H. Geerts,et al. Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice , 2001, Neurobiology of Disease.
[25] I. Vincent,et al. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases , 2000, Neurobiology of Aging.
[26] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[27] K. Lau,et al. Cyclin-Dependent Kinase-5/p35 Phosphorylates Presenilin 1 to Regulate Carboxy-Terminal Fragment Stability , 2002, Molecular and Cellular Neuroscience.
[28] P. Greengard,et al. Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5 , 2000, Journal of neurochemistry.
[29] I. Grundke‐Iqbal,et al. Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 , 1997, Molecular and Cellular Biochemistry.
[30] G. Schellenberg,et al. A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L) , 1999, Brain : a journal of neurology.
[31] L. Tsai,et al. Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons , 2004, The Journal of Neuroscience.
[32] F. Plattner,et al. Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression , 2003, The European journal of neuroscience.
[33] R. Aebersold,et al. A brain-specific activator of cyclin-dependent kinase 5 , 1994, Nature.
[34] D. Geschwind. Tau Phosphorylation, Tangles, and Neurodegeneration The Chicken or the Egg? , 2003, Neuron.
[35] M. Larsen,et al. Cdk5 is essential for synaptic vesicle endocytosis , 2003, Nature Cell Biology.
[36] L. Tsai,et al. Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29* , 2002, The Journal of Biological Chemistry.
[37] R. Nixon,et al. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease , 1997, Brain Research.
[38] Jerry H. Wang,et al. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors , 2003, Nature Neuroscience.
[39] David S. Park,et al. Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[40] A. Clark,et al. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain , 1999, Neuroscience Research.
[41] K. Mikoshiba,et al. Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles , 2003, The Journal of cell biology.
[42] P. Davies,et al. Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model , 2002, The Journal of Neuroscience.
[43] L. Tsai,et al. p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment , 2001, The Journal of Neuroscience.
[44] R. D. Williams,et al. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[45] L. Tsai,et al. The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin-1 in a Calcium-Dependent Manner , 2002, The Journal of Neuroscience.
[46] L. Tsai,et al. A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains , 2002, FEBS letters.
[47] L. Tsai,et al. APP processing is regulated by cytoplasmic phosphorylation , 2003, The Journal of cell biology.
[48] D. Geschwind,et al. Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila , 2002, Neuron.
[49] L. Tsai,et al. p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway* , 1998, The Journal of Biological Chemistry.
[50] H. Soininen,et al. Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35. , 2002, Brain research. Molecular brain research.
[51] M. D'Andrea. Evidence linking neuronal cell death to autoimmunity in Alzheimer’s disease , 2003, Brain Research.
[52] L. Tsai,et al. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 , 1994, Nature.
[53] Li-Huei Tsai,et al. Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles , 2003, Neuron.
[54] R. DePinho,et al. Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice , 2003, The Journal of Neuroscience.
[55] Joshua M. Shulman,et al. Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles , 2001, Science.
[56] T. Curran,et al. Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling , 2002, The Journal of Neuroscience.
[57] A. Bush,et al. Metals and neuroscience. , 2000, Current opinion in chemical biology.
[58] K. Wang,et al. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. , 2000, Biochemical and biophysical research communications.
[59] A. Delacourte,et al. Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy , 2002, Neurology.
[60] Jochen H Weishaupt,et al. Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction , 2003, Molecular and Cellular Neuroscience.
[61] L. Tsai,et al. Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality , 1997, Neuron.
[62] Taro Saito,et al. Truncation of CDK5 Activator p35 Induces Intensive Phosphorylation of Ser202/Thr205 of Human Tau* , 2002, The Journal of Biological Chemistry.
[63] L. Tsai,et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration , 1999, Nature.
[64] B. Wolozin,et al. The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease. , 2006, CNS drug reviews.
[65] K. Ishiguro,et al. Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25* , 2000, The Journal of Biological Chemistry.
[66] D. Flaherty,et al. Phosphorylation of human tau protein by microtubule‐associated kinases: GSK3β and cdk5 are key participants , 2000, Journal of neuroscience research.
[67] René Hen,et al. Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice , 2001 .
[68] A. Wynshaw-Boris,et al. A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System , 2000, Neuron.
[69] F. Liu,et al. Divergent roles of GSK3 and CDK5 in APP processing. , 2003, Biochemical and biophysical research communications.
[70] A. Kulkarni,et al. Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules* , 2003, The Journal of Biological Chemistry.
[71] R. Maccioni,et al. AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. , 2002, Journal of Alzheimer's disease : JAD.