The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

Increasing evidence connects the gut microbiota and the onset and/or phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial taxa have been reported in PD patients. It is, however, unknown whether these differences can be observed in individuals at high risk, for example, with idiopathic rapid eye movement sleep behavior disorder, a prodromal condition of α‐synuclein aggregation disorders including PD.

[1]  G. Deuschl,et al.  Gut microbiota in Parkinson disease in a northern German cohort , 2017, Brain Research.

[2]  Luis Pedro Coelho,et al.  Erratum to: Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients , 2017, Genome Medicine.

[3]  Anders F. Andersson,et al.  Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life , 2017, Front. Microbiol..

[4]  James T. Morton,et al.  Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome , 2017, Movement disorders : official journal of the Movement Disorder Society.

[5]  E. Pekkonen,et al.  Oral and nasal microbiota in Parkinson's disease. , 2017, Parkinsonism & related disorders.

[6]  Luis Pedro Coelho,et al.  Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients , 2017, Genome Medicine.

[7]  K. Doppler Hauttest erlaubt frühe Parkinsondiagnose , 2017 .

[8]  W. D. de Vos,et al.  Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function , 2017, PloS one.

[9]  J. Volkmann,et al.  Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson’s disease , 2017, Acta Neuropathologica.

[10]  A. Gobert,et al.  The human intestinal microbiota of constipated-predominant irritable bowel syndrome patients exhibits anti-inflammatory properties , 2016, Scientific Reports.

[11]  A. Heintz‐Buschart,et al.  IMP: a pipeline for reproducible reference-independent integrated metagenomic and metatranscriptomic analyses , 2016, Genome Biology.

[12]  F. Scheperjans Gut microbiota, 1013 new pieces in the Parkinson's disease puzzle. , 2016, Current opinion in neurology.

[13]  Rob Knight,et al.  Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease , 2016, Cell.

[14]  W. D. de Vos,et al.  A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice , 2016, Nature Medicine.

[15]  P. Wilmes,et al.  A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility , 2016, Cell.

[16]  K. Fassbender,et al.  Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. , 2016, Parkinsonism & related disorders.

[17]  T. Dinan,et al.  Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. , 2016, Journal of psychiatric research.

[18]  A. Heintz‐Buschart,et al.  Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes , 2016, Nature Microbiology.

[19]  E. Masliah,et al.  Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans , 2016, Scientific Reports.

[20]  Y. Li,et al.  Gut microbiota signatures of longevity , 2016, Current Biology.

[21]  M. Ota,et al.  Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. , 2016, Journal of affective disorders.

[22]  T. Friede,et al.  Monitoring of 30 marker candidates in early Parkinson disease as progression markers , 2016, Neurology.

[23]  A. Heintz‐Buschart,et al.  Identification, Recovery, and Refinement of Hitherto Undescribed Population-Level Genomes from the Human Gastrointestinal Tract , 2016, Front. Microbiol..

[24]  G. O’Keeffe,et al.  Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms. , 2016, Parkinsonism & related disorders.

[25]  J Licinio,et al.  Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism , 2016, Molecular Psychiatry.

[26]  T. Downing,et al.  The metabolism of the non-proteinogenic amino acid β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Synechocystis PCC6803. , 2016, Toxicon : official journal of the International Society on Toxinology.

[27]  Morris A. Swertz,et al.  Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity , 2016, Science.

[28]  B. Maček,et al.  Tyrosine 601 of Bacillus subtilis DnaK Undergoes Phosphorylation and Is Crucial for Chaperone Activity and Heat Shock Survival‡ , 2016, Front. Microbiol..

[29]  Jun Wang,et al.  Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota , 2015, Nature.

[30]  K. Ohno,et al.  Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease , 2015, PloS one.

[31]  E. Horváth-Puhó,et al.  Vagotomy and subsequent risk of Parkinson's disease , 2015, Annals of neurology.

[32]  C. Schadt,et al.  PanFP: pangenome-based functional profiles for microbial communities , 2015, BMC Research Notes.

[33]  Ali Keshavarzian,et al.  Colonic bacterial composition in Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.

[34]  M. Gorzelak,et al.  Methods for Improving Human Gut Microbiome Data by Reducing Variability through Sample Processing and Storage of Stool , 2015, PloS one.

[35]  Bing Ruan,et al.  Altered fecal microbiota composition in patients with major depressive disorder , 2015, Brain, Behavior, and Immunity.

[36]  B. Mollenhauer,et al.  Improved preparation of nasal lavage fluid (NLF) as a noninvasive sample for proteomic biomarker discovery. , 2015, Biochimica et biophysica acta.

[37]  R. Dobbs,et al.  Peripheral aetiopathogenic drivers and mediators of Parkinson’s disease and co-morbidities: role of gastrointestinal microbiota , 2015, Journal of NeuroVirology.

[38]  W. Oertel,et al.  A new dopaminergic nigro-olfactory projection , 2015, Acta Neuropathologica.

[39]  Jeroen Raes,et al.  Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates , 2015, Gut.

[40]  Rob Knight,et al.  Analysis of composition of microbiomes: a novel method for studying microbial composition , 2015, Microbial ecology in health and disease.

[41]  L. Lebrun,et al.  Method optimization for fecal sample collection and fecal DNA extraction. , 2015, Biopreservation and biobanking.

[42]  W. D. de Vos,et al.  Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer , 2015, Applied and Environmental Microbiology.

[43]  Jeffrey L. Curtis,et al.  Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals , 2015, mBio.

[44]  Michael W. Taylor,et al.  The nasal microbiota in health and disease: variation within and between subjects , 2015, Front. Microbiol..

[45]  E. Pekkonen,et al.  Gut microbiota are related to Parkinson's disease and clinical phenotype , 2015, Movement disorders : official journal of the Movement Disorder Society.

[46]  A. Méjean,et al.  Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria. , 2014, Toxicon : official journal of the International Society on Toxinology.

[47]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[48]  P. Bork,et al.  LotuS: an efficient and user-friendly OTU processing pipeline , 2014, Microbiome.

[49]  C. Bassis,et al.  The nasal cavity microbiota of healthy adults , 2014, Microbiome.

[50]  Anders F. Andersson,et al.  Systematic Design of 18S rRNA Gene Primers for Determining Eukaryotic Diversity in Microbial Consortia , 2014, PloS one.

[51]  Alexandros Stamatakis,et al.  Metagenomic species profiling using universal phylogenetic marker genes , 2013, Nature Methods.

[52]  T. Friede,et al.  Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort , 2013, Neurology.

[53]  P. Cox,et al.  The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation , 2013, PloS one.

[54]  Brian C. Thomas,et al.  The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria , 2013, eLife.

[55]  Carlos H Schenck,et al.  Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. , 2013, Sleep medicine.

[56]  C Trenkwalder,et al.  Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group. , 2013, Sleep medicine.

[57]  Susan Holmes,et al.  phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data , 2013, PloS one.

[58]  D. Devos,et al.  Colonic inflammation in Parkinson's disease , 2013, Neurobiology of Disease.

[59]  H. Shill,et al.  Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. , 2013, Journal of neuropathology and experimental neurology.

[60]  H. Reichmann,et al.  Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice , 2012, Scientific Reports.

[61]  Paul Wilmes,et al.  A biomolecular isolation framework for eco-systems biology , 2012, The ISME Journal.

[62]  Katherine H. Huang,et al.  Structure, Function and Diversity of the Healthy Human Microbiome , 2012, Nature.

[63]  Jeffrey H. Kordower,et al.  Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease , 2011, PloS one.

[64]  D. Higgins,et al.  Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega , 2011, Molecular systems biology.

[65]  E. Rizzi,et al.  Anatoxin-a Synthetase Gene Cluster of the Cyanobacterium Anabaena sp. Strain 37 and Molecular Methods To Detect Potential Producers , 2011, Applied and Environmental Microbiology.

[66]  H. Shill,et al.  Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders , 2010, Acta Neuropathologica.

[67]  Paramvir S. Dehal,et al.  FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments , 2010, PloS one.

[68]  D. Mash,et al.  Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease , 2009, Acta neurologica Scandinavica.

[69]  K. Chaudhuri,et al.  Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment , 2009, The Lancet Neurology.

[70]  K. Jellinger Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders , 2009, Acta Neuropathologica.

[71]  J. Jankovic,et al.  Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results , 2008, Movement disorders : official journal of the Movement Disorder Society.

[72]  Y. Jeon,et al.  Biosynthetic Intermediate Analysis and Functional Homology Reveal a Saxitoxin Gene Cluster in Cyanobacteria , 2008, Applied and Environmental Microbiology.

[73]  Rick L. Stevens,et al.  The RAST Server: Rapid Annotations using Subsystems Technology , 2008, BMC Genomics.

[74]  H. Braak,et al.  Parkinson's disease: a dual‐hit hypothesis , 2007, Neuropathology and applied neurobiology.

[75]  H. Braak,et al.  Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology , 2006, Neuroscience Letters.

[76]  R. Bidigare,et al.  Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[77]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[78]  Johan Marinus,et al.  Assessment of autonomic dysfunction in Parkinson's disease: The SCOPA‐AUT , 2004, Movement disorders : official journal of the Movement Disorder Society.

[79]  L. Durso,et al.  Measurements of Fitness and Competition in Commensal Escherichia coli and E. coli O157:H7 Strains , 2004, Applied and Environmental Microbiology.

[80]  P. Cox,et al.  Occurrence of β‐methylamino‐l‐alanine (BMAA) in ALS/PDC patients from Guam , 2004, Acta neurologica Scandinavica.

[81]  Korbinian Strimmer,et al.  APE: Analyses of Phylogenetics and Evolution in R language , 2004, Bioinform..

[82]  H. Braak,et al.  Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.

[83]  K. Bloch,et al.  German Version of the Epworth Sleepiness Scale , 1999, Respiration.

[84]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[85]  K. Walters,et al.  Prediagnostic presentations of Parkinson's disease in primary care: a case-control study , 2015, The Lancet Neurology.

[86]  Jens Roat Kultima,et al.  Disentangling the effects of type 2 diabetes and metformin on the human gut microbiota , 2015, Nature.

[87]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[88]  Siegfried Gauggel,et al.  Validität und Reliabilität einer deutschen Version der Geriatrischen Depressionsskala (GDS) , 1999 .

[89]  A. Schmidtke,et al.  [Studies of the reliability and validity of the German version of the Montgomery-Asberg Depression Rating Scale (MADRS)]. , 1988, Schweizer Archiv fur Neurologie und Psychiatrie.