Cohort Profile Update: The 45 and Up Study

The 45 and Up Study (‘the Study’) was developed to enhance population health. The Study provides researchers with reliable data on a wide range of exposures and outcomes of public health importance for the ageing population. The original 45 and Up Study profile paper was published in 2008 in the early stage of recruitment, describing the recruitment process and characteristics of the first 36 645 (14%) participants. The present paper profiles the final cohort of 267 357 men and women enrolled from the general population of New South Wales (NSW) and includes Study updates. Sampling and study design for the 45 and Up Study were described in Banks et al. Briefly, between 2005 and 2009, individuals aged 45 years and residing in NSW were randomly sampled from the Services Australia (formerly the Health Insurance Commission) Medicare enrolment database (MEDB) if they had received medical care within the previous 2 years. MEDB includes all citizens and permanent residents. Key Features

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