Subchronic (13‐week) inhalation toxicity study of formaldehyde in rats

Male and female albino Wistar rats were exposed to concentrations of 0, 1, 10 or 20 ppm formaldehyde vapour during 6 h/day, 5 days/wk for 13 weeks. Treatment‐related changes observed at 20 ppm included in both sexes: stared coats, uncoordinated locomotion and excitation during the first 30 minutes of each exposure, yellowing of the fur, growth retardation, a decreased level of plasma protein, severe and extensive karatinized stratified squamous metaplasia of the nasal respiratory epithelium, and focal degeneration and squamous metaplasia occasionally accompanied by keratinization of the olfactory epithelium; in males only; increased activities of plasma aspartate amino transferase (ASAT), alanine amino transferase (ALAT) and alkaline phosphatase (ALP) and squamous metaplasia of the laryngeal epithelium.

[1]  J A Swenberg,et al.  Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. , 1983, Cancer research.

[2]  J. J. Clary,et al.  A 26-week inhalation toxicity study with formaldehyde in the monkey, rat, and hamster. , 1983, Toxicology and applied pharmacology.

[3]  C. Barrow,et al.  Nasal cavity deposition, histopathology, and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. , 1983, Toxicology and applied pharmacology.

[4]  S Laskin,et al.  Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat. , 1982, Journal of the National Cancer Institute.

[5]  C. Barrow,et al.  Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats. , 1981, Toxicology and applied pharmacology.

[6]  J A Swenberg,et al.  Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor. , 1980, Cancer research.

[7]  V. Feron,et al.  An evaluation of the criterion "organ weight" under conditions of growth retardation. , 1973, Food and cosmetics toxicology.

[8]  H. V. Davis,et al.  BIOCHEMICAL EFFECTS IN RATS FROM IRRITATING AIR CONTAMINANTS. , 1964, Toxicology and applied pharmacology.

[9]  T NASH,et al.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. , 1953, The Biochemical journal.

[10]  V. Gutierrez-Millet,et al.  Pathology of the kidney in "toxic oil epidemic syndrome". , 1984, Journal of toxicology and environmental health.

[11]  A. Ulsamer,et al.  Formaldehyde and hepatotoxicity: a review. , 1984, Journal of toxicology and environmental health.

[12]  J. Gibson.  Comments on "Formaldehyde and Hepatotoxicity" by Beall and Ulsamer. , 1984, Journal of toxicology and environmental health.

[13]  V. Feron,et al.  Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies. , 1982, Toxicology.

[14]  J. Sedlák,et al.  Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. , 1968, Analytical biochemistry.

[15]  J. Galloway.  A Review of the , 1901 .