Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk

Anthony S. Zannas, Max Planck Institute of Psychiatry Meiwen Jia, Max Planck Institute of Psychiatry Kathrin Hafner, Max Planck Institute of Psychiatry Jens Baumert, German Research Center for Environmental Health Tobias Wiechmann, Max Planck Institute of Psychiatry Julius C. Pape, Max Planck Institute of Psychiatry Janine Arloth, Max Planck Institute of Psychiatry Maik Koedel, Max Planck Institute of Psychiatry Silvia Martinelli, Max Planck Institute of Psychiatry Maria Roitman, Max Planck Institute of Psychiatry

[1]  H. Woodrow,et al.  : A Review of the , 2018 .

[2]  Steve Horvath,et al.  DNA methylation-based biomarkers and the epigenetic clock theory of ageing , 2018, Nature Reviews Genetics.

[3]  A. Zannas Epigenetic mechanisms linking psychological stress and aging-related disease , 2017 .

[4]  R. von Känel,et al.  Psychological Stress, Inflammation, and Coronary Heart Disease , 2017, Current Cardiology Reports.

[5]  E. Binder,et al.  HAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing , 2017, Epigenetics & Chromatin.

[6]  G. Chrousos,et al.  Epigenetic programming by stress and glucocorticoids along the human lifespan , 2017, Molecular Psychiatry.

[7]  F. Holsboer,et al.  Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation , 2016, Biological Psychiatry.

[8]  Trey Ideker,et al.  Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA. , 2016, Molecular cell.

[9]  R. Valiathan,et al.  Effects of Ageing on the Immune System: Infants to Elderly , 2016, Scandinavian journal of immunology.

[10]  C. Bell,et al.  The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling , 2016, Science Translational Medicine.

[11]  Naomi R. Wray,et al.  Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling , 2015, Genome Biology.

[12]  V. Chopra,et al.  Elevated baseline plasma IL-8 levels are an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome. , 2015, Atherosclerosis.

[13]  M. Peinado,et al.  Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer , 2015, Epigenetics & Chromatin.

[14]  M. Masullo,et al.  FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma , 2015, Nucleic acids research.

[15]  S. Ozanne,et al.  Programming of cardiovascular disease across the life-course. , 2015, Journal of molecular and cellular cardiology.

[16]  S. Arora,et al.  Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis , 2015, British Journal of Cancer.

[17]  Ira Tabas,et al.  Inflammation and its Resolution as Determinants of Acute Coronary Syndromes , 2014, Circulation research.

[18]  Guangyu Zhang,et al.  Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. , 2014, Atherosclerosis.

[19]  R. Irizarry,et al.  Accounting for cellular heterogeneity is critical in epigenome-wide association studies , 2014, Genome Biology.

[20]  S. Horvath DNA methylation age of human tissues and cell types , 2013, Genome Biology.

[21]  C. Cotman,et al.  Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. , 2013, The Journal of clinical investigation.

[22]  Amit J. Shah,et al.  Post-traumatic stress disorder and incidence of coronary heart disease: a twin study. , 2013, Journal of the American College of Cardiology.

[23]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[24]  A. S. Nateri,et al.  The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter. , 2013, Current protocols in stem cell biology.

[25]  J. Wysocka,et al.  Modification of enhancer chromatin: what, how, and why? , 2013, Molecular cell.

[26]  T. Costantino,et al.  Neutrophil to lymphocyte ratio and cardiovascular diseases: a review , 2013, Expert review of cardiovascular therapy.

[27]  B. Bradley,et al.  Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions , 2012, Nature Neuroscience.

[28]  Linda Partridge,et al.  Ageing as a Risk Factor for Disease , 2012, Current Biology.

[29]  Alfonso Valencia,et al.  Distinct DNA methylomes of newborns and centenarians , 2012, Proceedings of the National Academy of Sciences.

[30]  Hyun-Jeong Ko,et al.  Functional Changes in Myeloid-Derived Suppressor Cells (MDSCs) during Tumor Growth: FKBP51 Contributes to the Regulation of the Immunosuppressive Function of MDSCs , 2012, The Journal of Immunology.

[31]  F. Holsboer,et al.  Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients , 2012, Neuropsychopharmacology.

[32]  Bruce S. McEwen,et al.  Adverse childhood experiences, allostasis, allostatic load, and age-related disease , 2012, Physiology & Behavior.

[33]  Manolis Kellis,et al.  ChromHMM: automating chromatin-state discovery and characterization , 2012, Nature Methods.

[34]  J. Potash,et al.  A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice , 2011, Psychopharmacology.

[35]  C. Pariante,et al.  Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor , 2011, Molecular Psychiatry.

[36]  Krishna R. Kalari,et al.  Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing , 2011, PloS one.

[37]  V. Willour,et al.  Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. , 2010, Endocrinology.

[38]  J. Buchner,et al.  The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules , 2010, The Journal of Neuroscience.

[39]  A. Caspi,et al.  Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. , 2009, Archives of pediatrics & adolescent medicine.

[40]  S. Ghosh,et al.  The NF-kappaB family of transcription factors and its regulation. , 2009, Cold Spring Harbor perspectives in biology.

[41]  A. Danese,et al.  27. Adverse childhood experiences predict adult risk factors for age-related disease: Depression, inflammation, and clustering of metabolic risk markers , 2009, Brain, behavior, and immunity.

[42]  A. Caspi,et al.  Elevated inflammation levels in depressed adults with a history of childhood maltreatment. , 2008, Archives of general psychiatry.

[43]  C. Meisinger,et al.  Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998. , 2008, Clinical chemistry.

[44]  Richie Poulton,et al.  Childhood maltreatment predicts adult inflammation in a life-course study , 2007, Proceedings of the National Academy of Sciences.

[45]  M. Rehli,et al.  Functional Analysis of Promoter CPG-Methylation using a CpG-Free Luciferase Reporter Vector , 2006, Epigenetics.

[46]  J. Walter,et al.  Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging* , 2006, Journal of Biological Chemistry.

[47]  Tarani Chandola,et al.  Chronic stress at work and the metabolic syndrome: prospective study , 2006, BMJ : British Medical Journal.

[48]  A. Döring,et al.  C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984-1998. , 2005, European heart journal.

[49]  S. Venuta,et al.  Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. , 2004, European journal of cancer.

[50]  R. Peters,et al.  IL-8 Plasma Concentrations and the Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women: The EPIC-Norfolk Prospective Population Study , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[51]  J. Rumsfeld,et al.  Depressive symptoms and health-related quality of life: the Heart and Soul Study. , 2003, JAMA.

[52]  C. Hsieh,et al.  DNA Methylation Has a Local Effect on Transcription and Histone Acetylation , 2002, Molecular and Cellular Biology.

[53]  T. Grange,et al.  Glucocorticoid‐induced DNA demethylation and gene memory during development , 2001, The EMBO journal.

[54]  D. Williamson,et al.  Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. , 1998, American journal of preventive medicine.

[55]  M. Martin,et al.  FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition , 1995, Molecular and cellular biology.

[56]  K. Matsushima,et al.  Essential involvement of interleukin‐8 (IL‐8) in acute inflammation , 1994, Journal of leukocyte biology.

[57]  D. Rubin,et al.  The central role of the propensity score in observational studies for causal effects , 1983 .

[58]  O. Hill A Twin Study , 1968, British Journal of Psychiatry.

[59]  E. Binder,et al.  Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications , 2016, Neuropsychopharmacology.

[60]  A. Bracher,et al.  Selective inhibitors of the FK506-binding protein 51 by induced fit. , 2015, Nature chemical biology.

[61]  G. Piwien-Pilipuk,et al.  NF- κ B regulation by FKBP51 and FKBP52 NF- κ B Transcriptional Activity is Modulated by FK506-binding Proteins FKBP51 and FKBP52: A Role for Peptidyl-prolyl Isomerase Activity* , 2014 .

[62]  D. Greenwood,et al.  Meta-analysis of Observational Studies , 2012 .

[63]  R. Huupponen,et al.  The Cardiovascular Risk in Young Finns Study , 2008 .

[64]  D. Goeddel,et al.  NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. , 1998, Proceedings of the National Academy of Sciences of the United States of America.