Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.

[1]  Li Huang,et al.  Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. , 2009, Journal of medicinal chemistry.

[2]  K. Benkestock,et al.  The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. , 2009, Journal of medicinal chemistry.

[3]  M. Irwin,et al.  2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups* , 2007, Journal of Biological Chemistry.

[4]  Erik De Clercq,et al.  The design of drugs for HIV and HCV , 2007, Nature Reviews Drug Discovery.

[5]  Wen Jiang,et al.  Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. , 2007, Bioorganic & medicinal chemistry letters.

[6]  C. George,et al.  A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides. , 2004, Journal of medicinal chemistry.

[7]  R. Schinazi,et al.  Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. , 2004, Current topics in medicinal chemistry.

[8]  M. Winters,et al.  A review of HIV-1 resistance to the nucleoside and nucleotide inhibitors. , 2003, Current drug targets. Infectious disorders.

[9]  B. Day,et al.  Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective , 2003, Nature Reviews Drug Discovery.

[10]  M. Matsuoka,et al.  Syntheses of 4‘-C-Ethynyl-β-d-arabino- and 4‘-C-Ethynyl-2‘-deoxy-β-d-ribo-pentofuranosylpyrimidines and -purines and Evaluation of Their Anti-HIV Activity , 2000 .

[11]  R. Schinazi,et al.  Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol. , 2000, Carbohydrate research.

[12]  J. Smeitink,et al.  Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway , 1998, AIDS.

[13]  J. Castaǹer,et al.  ANTIVIRAL FOR AIDS REVERSE TRANSCRIPTASE INHIBITOR , 1998 .

[14]  Y. L. Zhu,et al.  Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents. , 1996, Journal of medicinal chemistry.

[15]  Y. L. Zhu,et al.  Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil , 1996, Antimicrobial agents and chemotherapy.

[16]  G. Verdine,et al.  A Designed Inhibitor of Base-Excision DNA Repair , 1995 .

[17]  M. Chun,et al.  Synthesis and antiviral activity of fluoro sugar nucleosides 1: Studies on 4′-azido-2′-deoxy-2′-fluoro-arabinofuranosyl nucleosides , 1995 .

[18]  P. Bates,et al.  Analysis of the subgroup A avian sarcoma and leukosis virus receptor: the 40-residue, cysteine-rich, low-density lipoprotein receptor repeat motif of Tva is sufficient to mediate viral entry , 1995, Journal of virology.

[19]  R. Rydzewski,et al.  Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides. , 1992, Journal of medicinal chemistry.

[20]  N. Minakawa,et al.  Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives. , 1991, Journal of medicinal chemistry.

[21]  H. Mitsuya,et al.  Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV. , 1990, Journal of medicinal chemistry.

[22]  C. H. Chen,et al.  Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. , 1989, The Journal of biological chemistry.

[23]  L. Hertel,et al.  Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2'-difluoro-D-ribofuranosyl nucleosides , 1988 .

[24]  J. Minna,et al.  Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. , 1987, Cancer research.

[25]  K. Watanabe,et al.  Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides. , 1979, Journal of medicinal chemistry.