Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

[1]  Kazuki Tainaka,et al.  Mechanical load regulates bone growth via periosteal Osteocrin. , 2021, Cell reports.

[2]  E. Zeggini,et al.  Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease , 2020, Nature Communications.

[3]  Anne E Carpenter,et al.  Predicting cell health phenotypes using image-based morphology profiling , 2020, bioRxiv.

[4]  Brandon J. Ausk,et al.  A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction , 2020, Nature Communications.

[5]  Mingyao Li,et al.  Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment , 2020, eLife.

[6]  R. Raines,et al.  Hox genes maintain critical roles in the adult skeleton , 2020, Proceedings of the National Academy of Sciences.

[7]  L. Bonewald,et al.  The Osteocyte: New Insights. , 2020, Annual review of physiology.

[8]  D. Spray,et al.  Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels , 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  D. Sillence,et al.  Nosology and classification of genetic skeletal disorders: 2019 revision , 2019, American journal of medical genetics. Part A.

[10]  W. Qin,et al.  Exosomes and Extracellular RNA in Muscle and Bone Aging and Crosstalk , 2019, Current Osteoporosis Reports.

[11]  Klaus H. Kaestner,et al.  Emerging diverse roles of telocytes , 2019, Development.

[12]  Daohong Zhou.  Faculty Opinions recommendation of A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[13]  Samuel L. Wolock,et al.  Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths. , 2019, Cell reports.

[14]  Evan Z. Macosko,et al.  Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity , 2019, Cell.

[15]  Monika S. Kowalczyk,et al.  A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia , 2019, Cell.

[16]  R. Satija,et al.  The bone marrow microenvironment at single-cell resolution , 2019, Nature.

[17]  S. Dallas,et al.  Changes in the osteocyte lacunocanalicular network with aging. , 2019, Bone.

[18]  Alireza Hadj Khodabakhshi,et al.  Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.

[19]  Sakae Tanaka,et al.  Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging. , 2019, Cell metabolism.

[20]  O. Kennedy,et al.  In Vivo Osteocyte Mechanotransduction: Recent Developments and Future Directions , 2018, Current Osteoporosis Reports.

[21]  Evan Z. Macosko,et al.  Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain , 2018, Cell.

[22]  Erik Sundström,et al.  RNA velocity of single cells , 2018, Nature.

[23]  Anne E Carpenter,et al.  CellProfiler 3.0: Next-generation image processing for biology , 2018, PLoS biology.

[24]  G. Tseng,et al.  Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach , 2018, Scientific Reports.

[25]  A. Biggin,et al.  Novel variant in Sp7/Osx associated with recessive osteogenesis imperfecta with bone fragility and hearing impairment. , 2018, Bone.

[26]  N. Mochizuki,et al.  A New Secretory Peptide of Natriuretic Peptide Family, Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction , 2018, Circulation Research.

[27]  N. Mochizuki,et al.  Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance , 2017, The Journal of clinical investigation.

[28]  Charles P. Lin,et al.  Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy , 2017, PloS one.

[29]  J. Klein-Nulend,et al.  Aging, Osteocytes, and Mechanotransduction , 2017, Current Osteoporosis Reports.

[30]  Courtney M. Mazur,et al.  Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis , 2017, Scientific Reports.

[31]  N. Mochizuki,et al.  Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish , 2017, Development.

[32]  Anne E Carpenter,et al.  A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay , 2017, GigaScience.

[33]  A. Alexeev,et al.  cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs , 2016, Clinical Epigenetics.

[34]  Athar N. Malik,et al.  Evolution of Osteocrin as an activity-regulated factor in the primate brain , 2016, Nature.

[35]  D. Link,et al.  Targeting of Mesenchymal Stromal Cells by Cre‐Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[36]  L. Plotkin,et al.  Osteocytic signalling pathways as therapeutic targets for bone fragility , 2016, Nature Reviews Endocrinology.

[37]  R. Xavier,et al.  SIKs control osteocyte responses to parathyroid hormone , 2016, Nature Communications.

[38]  Jung-Eun Kim,et al.  Osterix is dispensable for the development of the mouse olfactory bulb. , 2016, Biochemical and biophysical research communications.

[39]  R. Ritchie,et al.  Parallel mechanisms suppress cochlear bone remodeling to protect hearing. , 2016, Bone.

[40]  Andrew P McMahon,et al.  Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. , 2016, Developmental cell.

[41]  Anne E Carpenter,et al.  Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes , 2016, Nature Protocols.

[42]  Fidel Ramírez,et al.  deepTools2: a next generation web server for deep-sequencing data analysis , 2016, Nucleic Acids Res..

[43]  Wei Wang,et al.  Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2. , 2016, Bone.

[44]  S. Reyes,et al.  Musclin is an activity-stimulated myokine that enhances physical endurance , 2015, Proceedings of the National Academy of Sciences.

[45]  Qing-Yu He,et al.  ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization , 2015, Bioinform..

[46]  N. Sims,et al.  Quantifying the osteocyte network in the human skeleton. , 2015, Bone.

[47]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[48]  John G Doench,et al.  HDAC5 Controls MEF2C‐Driven Sclerostin Expression in Osteocytes , 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[49]  B. van Steensel,et al.  Easy quantitative assessment of genome editing by sequence trace decomposition , 2014, Nucleic acids research.

[50]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[51]  Ning Leng,et al.  The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone. , 2014, Molecular endocrinology.

[52]  Cole Trapnell,et al.  The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells , 2014, Nature Biotechnology.

[53]  Cole Trapnell,et al.  Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions , 2014, Nature Biotechnology.

[54]  G. Loots,et al.  Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner☆ , 2013, Developmental biology.

[55]  Sarah L Dallas,et al.  The osteocyte: an endocrine cell ... and more. , 2013, Endocrine reviews.

[56]  Sara E Strecker,et al.  Generation and characterization of Osterix‐Cherry reporter mice , 2013, Genesis.

[57]  D. Menke,et al.  Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements. , 2013, Developmental biology.

[58]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[59]  Alexander van Oudenaarden,et al.  Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. , 2012, Genes & development.

[60]  G. Loots,et al.  Targeted deletion of Sost distal enhancer increases bone formation and bone mass , 2012, Proceedings of the National Academy of Sciences.

[61]  T. Craig,et al.  Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton. , 2012, Gene expression patterns : GEP.

[62]  L. Bonewald,et al.  Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. , 2012, BioTechniques.

[63]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[64]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[65]  C. Halleux,et al.  Mef2c deletion in osteocytes results in increased bone mass , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[66]  C. Halleux,et al.  Isolation of mouse osteocytes using cell fractionation for gene expression analysis. , 2012, Methods in molecular biology.

[67]  J. Flanagan,et al.  RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. , 2012, The Journal of molecular diagnostics : JMD.

[68]  Atum M. Buo,et al.  The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. , 2011, Bone.

[69]  Timothy L. Bailey,et al.  Gene expression Advance Access publication May 4, 2011 DREME: motif discovery in transcription factor ChIP-seq data , 2011 .

[70]  Jung-Eun Kim,et al.  In vivo expression of Osterix in mature granule cells of adult mouse olfactory bulb. , 2011, Biochemical and biophysical research communications.

[71]  P. Penzes,et al.  Dendritic spine pathology in neuropsychiatric disorders , 2011, Nature Neuroscience.

[72]  L. Bonewald,et al.  The Amazing Osteocyte , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[73]  R. Taschereau,et al.  Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures , 2010, Nucleic acids research.

[74]  Daniel P Nicolella,et al.  Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels , 2010, Proceedings of the National Academy of Sciences.

[75]  P. Lapunzina,et al.  Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta. , 2010, American journal of human genetics.

[76]  Jian Q. Feng,et al.  Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice , 2010, Proceedings of the National Academy of Sciences.

[77]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[78]  Aaron R. Quinlan,et al.  BIOINFORMATICS APPLICATIONS NOTE , 2022 .

[79]  H. Yasuda,et al.  Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase , 2009, The EMBO journal.

[80]  Mark D. Robinson,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[81]  G. Karsenty,et al.  Genetic control of bone formation. , 2009, Annual review of cell and developmental biology.

[82]  D. Rowe,et al.  Identification of differentially expressed genes between osteoblasts and osteocytes. , 2009, Bone.

[83]  Yurii S. Aulchenko,et al.  Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies , 2009, Nature Genetics.

[84]  O. Verborgt,et al.  Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[85]  Caleb B. McDonald,et al.  Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor. , 2009, Biochemistry.

[86]  Cole Trapnell,et al.  Ultrafast and memory-efficient alignment of short DNA sequences to the human genome , 2009, Genome Biology.

[87]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[88]  A. Schilling,et al.  The protein tyrosine phosphatase Rptpzeta is expressed in differentiated osteoblasts and affects bone formation in mice. , 2008, Bone.

[89]  E. Wagner,et al.  Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease , 2008, Arthritis research & therapy.

[90]  C. Lanctôt,et al.  Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth* , 2007, Journal of Biological Chemistry.

[91]  F. Natt,et al.  Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[92]  V. Jorgetti,et al.  Brazilian normal static bone histomorphometry: effects of age, sex, and race , 2007, Journal of Bone and Mineral Metabolism.

[93]  Anirvan Ghosh,et al.  Transcriptional regulation of vertebrate axon guidance and synapse formation , 2007, Nature Reviews Neuroscience.

[94]  L. Bonewald,et al.  DMP1-targeted Cre Expression in Odontoblasts and Osteocytes , 2007, Journal of dental research.

[95]  John McAnally,et al.  MEF2C transcription factor controls chondrocyte hypertrophy and bone development. , 2007, Developmental cell.

[96]  Stephen E. Harris,et al.  E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation , 2006, Molecular and Cellular Biology.

[97]  A. Parfitt,et al.  Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[98]  B. Hall,et al.  Buried alive: How osteoblasts become osteocytes , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[99]  J. Reeve,et al.  The FASEB Journal express article 10.1096/fj.05-4221fje. Published online August 25, 2005. ©2005 FASEB , 2022 .

[100]  J. Deng,et al.  Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[101]  G. Thomas,et al.  Characterization of Osteocrin Expression in Human Bone , 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[102]  Xunbin Wei,et al.  In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment , 2005, Nature.

[103]  Sheldon Weinbaum,et al.  Mechanotransduction and strain amplification in osteocyte cell processes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[104]  M. Matsuda,et al.  Musclin, a Novel Skeletal Muscle-derived Secretory Factor* , 2004, Journal of Biological Chemistry.

[105]  C. Lanctôt,et al.  Osteocrin, a Novel Bone-specific Secreted Protein That Modulates the Osteoblast Phenotype* , 2003, Journal of Biological Chemistry.

[106]  John A Latham,et al.  Osteocyte control of bone formation via sclerostin, a novel BMP antagonist , 2003, The EMBO journal.

[107]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[108]  David L. Lacey,et al.  Osteoclast differentiation and activation , 2003, Nature.

[109]  J. Deng,et al.  The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation , 2002, Cell.

[110]  G. Karsenty,et al.  The osteoblast: a sophisticated fibroblast under central surveillance. , 2000, Science.

[111]  O. Verborgt,et al.  Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[112]  M E Greenberg,et al.  Neuronal activity-dependent cell survival mediated by transcription factor MEF2. , 1999, Science.