Management of erythema multiforme associated with recurrent herpes infection: a case report.

Erythema multiforme is an acute mucocutaneous disorder, characterized by varying degrees of blistering and ulceration. We report a case of recurrent herpes-associated erythema multiforme managed with prophylactic acyclovir. An 11-year-old boy had lesions in the oral cavity and lips, which had been diagnosed as erythema multiforme minor. Four months later, the patient had desquamative gingivitis with erythematous lesions and necrotic areas in the skin. This episode was not related to drug intake, which suggests that the erythema multiforme was a result of herpetic infection. This hypothesis was supported by positive serology for herpes simplex virus. Five months later, the patient returned with new oral, skin and penis mucosal lesions. The diagnosis was confirmed as herpes simplex virus-associated erythema multiforme major. The episode was treated with acyclovir, and acyclovir was used prophylactically for 7 months to control the disease.

[1]  S. Porter,et al.  Erythema multiforme and related disorders. , 2007, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[2]  S. Challacombe,et al.  Management of recurrent oral herpes simplex infections. , 2007, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[3]  P. Williams,et al.  Erythema multiforme. , 2006, American family physician.

[4]  C. Scully,et al.  Number IV Erythema multiforme , 2005 .

[5]  Christian Aburto Torres,et al.  Síndrome de Stevens-Johnson asociado a infección por mycoplasma pneumoniae y virus herpes , 2005 .

[6]  W. Weston.  Herpes-associated erythema multiforme. , 2005, The Journal of investigative dermatology.

[7]  C. Scully.  Mucosal diseases series. , 2005, Oral diseases.

[8]  C. Scully,et al.  Mucosal disease series. Number IV. Erythema multiforme. , 2005, Oral diseases.

[9]  Carmen Gavalda-Esteve,et al.  Eritema multiforme: Revisión y puesta al día , 2004 .

[10]  S. Tan,et al.  Detection of Herpes simplex Virus Genomic DNA in Various Subsets of Erythema multiforme by Polymerase Chain Reaction , 2004, Dermatology.

[11]  S. Tan,et al.  Detection and genotyping of human herpes simplex viruses in cutaneous lesions of erythema multiforme by nested PCR , 2003, Journal of medical virology.

[12]  D. Pandhi,et al.  Erythema multiforme in a 9‐day‐old neonate , 2003, Pediatric dermatology.

[13]  L. Aurelian,et al.  Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): a viral disease with an autoimmune component. , 2003, Dermatology online journal.

[14]  E. Bröcker,et al.  CC and CXC chemokines are differentially expressed in erythema multiforme in vivo. , 2002, Archives of dermatology.

[15]  H. T. Shin,et al.  Drug eruptions in children. , 2001, Current problems in pediatrics.

[16]  K. Bowers.  Oral blistering diseases. , 2000, Clinics in dermatology.

[17]  L. Aurelian,et al.  Herpes Simplex Virus Associated Erythema Multiforme (HAEM) is Mechanistically Distinct from Drug-Induced Erythema Multiforme: Interferon-γ is Expressed in HAEM Lesions and Tumor Necrosis Factor-α in Drug-Induced Erythema Multiforme Lesions , 1999 .

[18]  Aurelian,et al.  Erythema multiforme lesions are associated with expression of a herpes simplex virus (HSV) gene and qualitative alterations in the HSV‐specific T‐cell response , 1998, The British journal of dermatology.

[19]  I. Leigh,et al.  Characteristics of the oral lesions in patients with cutaneous recurrent erythema multiforme. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[20]  Elisa Pi Asensio,et al.  Spanish , 1958, Cheers!.