LOH-proficient embryonic stem cells: a model of cancer progenitor cells?

[1]  Lawrence D True,et al.  Human cancers express a mutator phenotype , 2006, Proceedings of the National Academy of Sciences.

[2]  H. Ruley,et al.  Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[3]  B. De Baets,et al.  Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[4]  G. McFadden,et al.  Complete nucleotide sequence of the chlorarachniophyte nucleomorph: nature's smallest nucleus. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Stefan Zauner,et al.  Protein Targeting into the Complex Plastid of Cryptophytes , 2006, Journal of Molecular Evolution.

[6]  P. Keeling,et al.  The complete plastid genome sequence of the parasitic green alga Helicosporidium sp. is highly reduced and structured , 2006, BMC biology.

[7]  C. Slamovits,et al.  Causes and effects of nuclear genome reduction. , 2005, Current opinion in genetics & development.

[8]  B Franz Lang,et al.  The tree of eukaryotes. , 2005, Trends in ecology & evolution.

[9]  Geert J. P. L. Kops,et al.  On the road to cancer: aneuploidy and the mitotic checkpoint , 2005, Nature Reviews Cancer.

[10]  N. Patron,et al.  A high frequency of overlapping gene expression in compacted eukaryotic genomes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J. Bielas,et al.  Quantification of random genomic mutations , 2005, Nature Methods.

[12]  A. Vinogradov.  Evolution of genome size: multilevel selection, mutation bias or dynamical chaos? , 2004, Current opinion in genetics & development.

[13]  Carrie A. Hendricks,et al.  "Recombomice": the past, present, and future of recombination-detection in mice. , 2004, DNA repair.

[14]  M. Lynch,et al.  The Origins of Genome Complexity , 2003, Science.

[15]  K. Loeb,et al.  Multiple mutations and cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Fabienne Thomarat,et al.  Functional and evolutionary analysis of a eukaryotic parasitic genome. , 2002, Current opinion in microbiology.

[17]  G. McFadden,et al.  Jam packed genomes – a preliminary, comparative analysis of nucleomorphs , 2002, Genetica.

[18]  J. Stringer,et al.  Embryonic stem cells and somatic cells differ in mutation frequency and type , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Giovanni Parmigiani,et al.  Prevalence of somatic alterations in the colorectal cancer cell genome , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Fabienne Thomarat,et al.  Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi , 2001, Nature.

[21]  Michael Reith,et al.  The highly reduced genome of an enslaved algal nucleus , 2001, Nature.

[22]  L. Lefebvre,et al.  Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity , 2001, Nature Genetics.

[23]  T. Gregory,et al.  Coincidence, coevolution, or causation? DNA content, cellsize, and the C‐value enigma , 2001, Biological reviews of the Cambridge Philosophical Society.

[24]  N. Shima,et al.  Dietary restriction during murine development provides protection against MNU-induced mutations. , 2000, Mutation research.

[25]  N. Petrelli,et al.  The onset and extent of genomic instability in sporadic colorectal tumor progression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[26]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[27]  T. Skopek,et al.  A comparative study of in vivo mutation assays: analysis of hprt, lacI, cII/cI and as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue mice. , 1998, Mutation research.

[28]  T. Cavalier-smith,et al.  Bonsai genomics: sequencing the smallest eukaryotic genomes. , 1997, Trends in genetics : TIG.

[29]  W F Bodmer,et al.  The mutation rate and cancer. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Short,et al.  Development of a rat cell line containing stably integrated copies of a lambda/lacI shuttle vector. , 1995, Mutation research.

[31]  H. Claustre,et al.  Smallest eukaryotic organism , 1994, Nature.

[32]  R. Pieper,et al.  The role of the carboxyl-terminal tail in human O6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity. , 1993, Journal of Biological Chemistry.

[33]  J. Seidman,et al.  Production of homozygous mutant ES cells with a single targeting construct , 1992, Molecular and cellular biology.

[34]  D. Grunberger,et al.  Molecular Biology of Mutagens and Carcinogens , 1983, Springer US.

[35]  T. Cavalier-smith,et al.  Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox. , 1978, Journal of cell science.

[36]  A. Mirsky,et al.  THE DESOXYRIBONUCLEIC ACID CONTENT OF ANIMAL CELLS AND ITS EVOLUTIONARY SIGNIFICANCE , 1951, The Journal of general physiology.

[37]  A. Feinberg,et al.  The epigenetic progenitor origin of human cancer , 2006, Nature Reviews Genetics.

[38]  J. Bielas,et al.  Mutator phenotype in cancer: Timing and perspectives , 2005, Environmental and molecular mutagenesis.

[39]  T. Cavalier-smith.  Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansion. , 2005, Annals of botany.

[40]  H. Vrieling,et al.  Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes. , 2003, Carcinogenesis.

[41]  Reinhold G. Herrmann,et al.  Complete nucleotide sequence of the , 2000 .

[42]  P. Nowell.  Foundations in cancer research. Chromosomes and cancer: the evolution of an idea. , 1993, Advances in cancer research.

[43]  R. Weinberg,et al.  The Biology of Cancer , 2006 .