Evaluation of the efficiency of hydrolyzed whey formula to prevent cow’s milk allergy in the BALB/c mouse model

Partially hydrolyzed milk formulas have been proposed for primary prevention in at‐risk infants, but evidence of their efficiency and elucidation of the underlying mechanisms are still lacking. Thanks to a Th2‐biased mouse model mimicking at‐risk patients, we aimed to assess the potency of a partially hydrolyzed whey formula (pHWF) to induce oral tolerance thus preventing further cow's milk (CM) allergy.

[1]  K. Adel‐Patient,et al.  Intragastric administration of Lactobacillus casei BL23 induces regulatory FoxP3+RORγt+ T cells subset in mice. , 2017, Beneficial microbes.

[2]  M. Akdiş,et al.  Role of Regulatory Cells in Oral Tolerance , 2016, Allergy, asthma & immunology research.

[3]  M. Trivella,et al.  Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis , 2016, British Medical Journal.

[4]  A. Nowak‐Wegrzyn,et al.  Non-IgE-mediated gastrointestinal food allergy. , 2015, The Journal of allergy and clinical immunology.

[5]  O. Kheroua,et al.  Influence d’une formule infantile hypoallergénique sur la réponse antigénique des souris Balb/c sensibilisées à la bêta-lactoglobuline (β-lg) , 2015 .

[6]  A. Sheikh,et al.  EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy , 2014, Allergy.

[7]  J. Wal,et al.  Immunomodulatory potential of partially hydrolyzed β-lactoglobulin and large synthetic peptides. , 2012, Journal of agricultural and food chemistry.

[8]  J. Garssen,et al.  Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3+ regulatory T‐cells in the mesenteric lymph nodes , 2011, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[9]  J. Wal,et al.  Oral tolerance and Treg cells are induced in BALB/c mice after gavage with bovine β‐lactoglobulin , 2011, Allergy.

[10]  C. Hsieh,et al.  Becoming self-aware: the thymic education of regulatory T cells. , 2011, Current opinion in immunology.

[11]  A. Burks,et al.  Mechanisms of immune tolerance relevant to food allergy. , 2011, The Journal of allergy and clinical immunology.

[12]  S. Sicherer.  Epidemiology of food allergy. , 2011, The Journal of allergy and clinical immunology.

[13]  L. Barraj,et al.  Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature. , 2010, Nutrition reviews.

[14]  C. Akdis,et al.  T regulatory cells and their counterparts: masters of immune regulation , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[15]  S. Alessandri,et al.  Update on optimized purification and characterization of natural milk allergens. , 2008, Molecular nutrition & food research.

[16]  R. Wood,et al.  A systematic review of the role of hydrolyzed infant formulas in allergy prevention. , 2005, Archives of pediatrics & adolescent medicine.

[17]  J. Wal,et al.  Peanut‐ and cow's milk‐specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin , 2005, Allergy.

[18]  M. Karlsson,et al.  Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy , 2004, The Journal of experimental medicine.

[19]  P. Eigenmann,et al.  Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy. , 2004, The Journal of allergy and clinical immunology.

[20]  J. Tsai,et al.  Effect of ingestion of cow's milk hydrolysed formulas on whey protein‐specific Th2 immune responses in naïve and sensitized mice , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  J. Wal,et al.  Evaluation of a high IgE-responder mouse model of allergy to bovine beta-lactoglobulin (BLG): development of sandwich immunoassays for total and allergen-specific IgE, IgG1 and IgG2a in BLG-sensitized mice. , 2000, Journal of immunological methods.

[22]  J. Wal.  Cow's milk allergens , 1998, Allergy.

[23]  A. Pfeifer,et al.  Induction of systemic immunologic tolerance to beta-lactoglobulin by oral administration of a whey protein hydrolysate. , 1997, The Journal of allergy and clinical immunology.

[24]  H. Sampson,et al.  Epicutaneous immunotherapy induces gastrointestinal LAP+ regulatory T cells and prevents food‐induced anaphylaxis , 2017, The Journal of allergy and clinical immunology.