The Human Pupil as a Model for Clinical Pharmacological Investigations

Experimental systems for the study of autonomically-acting drugs in man are limited by criteria of safety and patient acceptability. Although many invasive techniques are safe when carried out under the supervision of experienced investigators, they may not be sufficiently acceptable to the patient to encourage him to tolerate them on repeated occasions. This has encouraged clinical pharmacologists to develop non-invasive and acceptable techniques that are sensitive enough to demonstrate meaningful pharmacological activity of established and new drugs. studied the pupil responses of a compared them with those of control for and Methacholine 2-5 per cent 0-5 per cent eye miosis compared with the control subjects. The mydriasis also in the patient, ephedrine, mydriasis the controls, measurable