[DNA adducts in human female genital organs].

DNA adducts, one of genetic damages markers, precede and finally can lead to oncogenic mutations. They appear in genome as a result of DNA bases damages caused by various and numerous environmental factors eg. ultraviolet light, ionic radiation, toxins and also endogenic substances, for example estrogens. It is believed that the creation of DNA adducts is a necessary but insufficient process for the neoplastic transformation of the cell. The following review presents concise knowledge about the DNA adducts creation and their sequels served in healthy and cancerous tissues of the female genital organs, on the base of the available data.

[1]  E. Reed,et al.  A Gynecologic Oncology Group study of platinum-DNA adducts and excision repair cross-complementation group 1 expression in optimal, stage III epithelial ovarian cancer treated with platinum-taxane chemotherapy. , 2007, Cancer research.

[2]  V. Brabec,et al.  Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin , 2007, Nucleic acids research.

[3]  S. Elledge,et al.  The DNA damage response: putting checkpoints in perspective , 2000, Nature.

[4]  T. Sugimura,et al.  Genetic and epigenetic alterations in carcinogenesis. , 2000, Mutation research.

[5]  R. Santella,et al.  Carcinogen macromolecular adducts and their measurement. , 2000, Carcinogenesis.

[6]  D Hoffmann,et al.  Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry. , 1999, Cancer letters.

[7]  A. Grollman,et al.  Tamoxifen-DNA adducts detected in the endometrium of women treated with tamoxifen. , 1999, Chemical research in toxicology.

[8]  Z. Wang,et al.  Repair of DNA lesions: mechanisms and relative repair efficiencies. , 1999, Mutation research.

[9]  S. Nesnow,et al.  Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations. , 1999, Mutation research.

[10]  T. Bourne,et al.  Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium. , 1999, Carcinogenesis.

[11]  K. Hemminki,et al.  Abundant lipophilic DNA adducts in human tissues. , 1998, Mutation research.

[12]  F P Perera,et al.  Environment and cancer: who are susceptible? , 1997, Science.

[13]  K. Hemminki,et al.  Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. , 1996, Cancer research.

[14]  D. Gaylor,et al.  Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence. , 1996, Regulatory toxicology and pharmacology : RTP.

[15]  K. Hemminki,et al.  DNA and protein adducts. , 1995, Toxicology.

[16]  A. Dipple,et al.  DNA adducts of chemical carcinogens. , 1995, Carcinogenesis.

[17]  G. Keith,et al.  Postlabeling: a sensitive method for studying DNA adducts and their role in carcinogenesis. , 1995, Current opinion in biotechnology.

[18]  J. Cuzick,et al.  The detection of adducts in human cervix tissue DNA using 32P-postlabelling: a study of the relationship with smoking history and oral contraceptive use. , 1994, Carcinogenesis.

[19]  S. Hsia,et al.  Macromolecular adducts: biomarkers for toxicity and carcinogenesis. , 1994, Annual review of pharmacology and toxicology.

[20]  L. Marnett,et al.  Endogenous DNA adducts: potential and paradox. , 1993, Chemical research in toxicology.

[21]  T. A. Avitts,et al.  Estrogen-induced endogenous DNA adduction: possible mechanism of hormonal cancer. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[22]  R. Gupta,et al.  32P-labeling test for DNA damage. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[23]  D. Kaufman,et al.  Benzo(a)pyrene binding to DNA in organ cultures of human endometrium. , 1981, Cancer research.