Adaptation – not by sweeps alone

There has been recent progress in identifying selective sweeps underlying a range of adaptations. Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection.

[1]  F. Hospital,et al.  Selective Sweep at a Quantitative Trait Locus in the Presence of Background Genetic Variation , 2008, Genetics.

[2]  Kosuke M. Teshima,et al.  Directional Positive Selection on an Allele of Arbitrary Dominance , 2006, Genetics.

[3]  N. Barton,et al.  Genetic hitchhiking. , 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[4]  T. Lenormand,et al.  The Distribution of Beneficial and Fixed Mutation Fitness Effects Close to an Optimum , 2008, Genetics.

[5]  G. Perry,et al.  Evolution of the human pygmy phenotype. , 2009, Trends in ecology & evolution.

[6]  David B. Witonsky,et al.  Adaptations to new environments in humans: the role of subtle allele frequency shifts , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[7]  J. Hermisson,et al.  Soft Sweeps , 2005, Genetics.

[8]  David M. Evans,et al.  Genome-wide association analysis identifies 20 loci that influence adult height , 2008, Nature Genetics.

[9]  A. Clark,et al.  Recent and ongoing selection in the human genome , 2007, Nature Reviews Genetics.

[10]  Joseph K. Pickrell,et al.  The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation , 2010, Current Biology.

[11]  F. Ayala,et al.  Human Adaptations to Diet, Subsistence, and Ecoregion Are Due to Subtle Shifts in Allele Frequency , 2010 .

[12]  H. Grüneberg,et al.  Introduction to quantitative genetics , 1960 .

[13]  P. Green,et al.  Widespread Genomic Signatures of Natural Selection in Hominid Evolution , 2009, PLoS genetics.

[14]  N. Barton,et al.  Multifactorial genetics: Understanding quantitative genetic variation , 2002, Nature Reviews Genetics.

[15]  J. M. Smith,et al.  The hitch-hiking effect of a favourable gene. , 1974, Genetical research.

[16]  S. Otto,et al.  Two steps forward, one step back: the pleiotropic effects of favoured alleles , 2004, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[17]  J. Hermisson,et al.  The Genetic Basis of Phenotypic Adaptation II: The Distribution of Adaptive Substitutions in the Moving Optimum Model , 2009, Genetics.

[18]  Pardis C Sabeti,et al.  Positive Natural Selection in the Human Lineage , 2006, Science.

[19]  J. Gillespie The causes of molecular evolution , 1991 .