Is sensorineural hearing loss related with thyroid metabolism disorders

Objectives: In this study, we measured hearing thresholds in patients diagnosed with hyperthyroidism or hypothyroidism with high-frequency audiometry and otoacoustic emission before and after treatment to determine whether hearing losses were cochlear or retrocochlear and whether they would improve with medical therapy. Materials and Methods: This study was conducted on patients diagnosed with hyperthyroidism and hypothyroidism at Cumhuriyet University, Faculty of Medicine, Department of Endocrinology and Metabolism and accepting to participate in the study. We measured the hearing thresholds of the study population during the pretreatment period and in posttreatment euthyroid period. Result: The audiometric findings of patients with hyperthyroidism were better than those of the control group especially at high frequencies. Sensorineural hearing loss was detected in the euthyroid period. We compared the audiometric findings of the patients with hypothyroidism and the controls. We found sensorineural hearing loss in patients with hypothyroidism, especially at low frequencies. Conclusions: The results of this study showed that both hyperthyroidism and hypothyroidism may have an effect on hearing pathway disorders. Medical therapy may lead to hearing loss in patients with hyperthyroidism, and the underlying factors should be investigated in detailed future studies. It was shown in our study that the hearing loss induced by hypothyroidism may improve with medical therapy. Therefore, in all patients with thyroid dysfunction, hearing levels should be monitored closely with audiometric tests.

[1]  M. Mustapha,et al.  Genetic Background of Prop1df Mutants Provides Remarkable Protection Against Hypothyroidism-Induced Hearing Impairment , 2011, Journal of the Association for Research in Otolaryngology.

[2]  B. Goichot,et al.  [Subclinical thyroid dysfunction]. , 2011, Presse medicale.

[3]  L. R. de Carvalho,et al.  Audiologic evaluation in patients with acquired hypothyroidism , 2015, Brazilian journal of otorhinolaryngology.

[4]  Engin Güney,et al.  [The relationship between hypothyroidism and rhinitis]. , 2010, Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat.

[5]  A. Thornton,et al.  Auditory brainstem response findings in hypothyroid and hyperthyroid disease , 2008, Clinical Neurophysiology.

[6]  Z. Kevanishvili,et al.  The hearing system under thyroid hypofunction. , 2007, Georgian medical news.

[7]  A. Ramé,et al.  Diseases of the Thyroid , 1963 .

[8]  N. Kitahara,et al.  Progressive Bilateral Sensorineural Hearing Loss Induced by an Antithyroid Drug , 2004, ORL.

[9]  L. Braverman,et al.  Diseases of the thyroid , 2002 .

[10]  R. Ehrlich,et al.  Long-term sequelae of hearing impairment in congenital hypothyroidism. , 1996, The Journal of pediatrics.

[11]  C. Wang,et al.  Propylthiouracil hypersensitivity with circumstantial evidence for drug-induced reversible sensorineural deafness: a case report. , 1991, Hormone Research.

[12]  Guidelines for screening for hearing impairment and middle-ear disorders. Working Group on Acoustic Immittance Measurements and the Committee on Audiologic Evaluation. American Speech-Language-Hearing Association. , 1990, ASHA. Supplement.

[13]  C. Fischer,et al.  Normal brainstem auditory evoked potentials in adult hypothyroidism , 1989, The Laryngoscope.

[14]  Y. N. Mehra,et al.  Auditory investigations in hypothyroidism. , 1989, Acta oto-laryngologica.

[15]  A. Eshleman Diagnosis of hypothyroidism. , 1986, Postgraduate medicine.

[16]  M. NaeemulHaque Diagnosis of hypothyroidism. , 1986 .

[17]  N. Laurian,et al.  Auditory brain stem response in experimentally induced hypothyroidism in albino rats , 1985, The Laryngoscope.

[18]  F. Debruyne,et al.  Hearing in congenital hypothyroidism. , 1983, Audiology : official organ of the International Society of Audiology.

[19]  M. Himelfarb,et al.  Auditory brain stem responses in thyroid dysfunction , 1981, The Journal of Laryngology & Otology.

[20]  William L. Meyerhoff Hypothyroidism and the ear: Electrophysiological, morphological, and chemical considerations , 1979, The Laryngoscope.

[21]  W. van't HOFF,et al.  Deafness in myxoedema. , 1979, The Quarterly journal of medicine.

[22]  G. Dokianakis,et al.  [Hearing loss and hyperthyroidism (author's transl)]. , 1978, Archives of oto-rhino-laryngology.

[23]  M. Hildesheimer,et al.  Cochlear action potentials in experimentally induced hypothyroidism in guinea pigs. , 1975, Acta oto-laryngologica. Supplementum.

[24]  S. Stephens Temporary threshold drift in myxoedema , 1970, The Journal of Laryngology & Otology.

[25]  F. N. Ritter,et al.  The effects of hypothyroidism upon the ear, nose and throat : A clinical and experimental study , 1967, The Laryngoscope.

[26]  I. Friedman DEAFNESS IN MYXEDEMA. , 1964, New York state journal of medicine.

[27]  H. E. Lloyd,et al.  Perceptive Deafness in Hypothyroidism , 1956, British medical journal.

[28]  R. C. Moehlig VERTIGO AND DEAFNESS ASSOCIATED WITH HYPOTHYROIDISM , 1927 .