Calcium as the associative signal for a model of Hebbian plasticity: application to multi-input environments

Abstract The sign and magnitude of bi-directional synaptic plasticity have been shown to depend on: the rate of presynaptic stimulation, the level of postsynaptic depolarization, and the precise relative timing between pre- and postsynaptic spikes. It has been proposed that these different induction paradigms can coexist, and be accounted for by a single learning rule that depends on the dynamics of intracellular calcium concentration. We extend this rule to a multi-synaptic environment, where collective properties such as cooperativity, competition and selectivity can be investigated.

[1]  Gastone C. Castellani,et al.  Converging evidence for a simplified biophysical model of synaptic plasticity , 2002, Biological Cybernetics.

[2]  A. C. Greenwood,et al.  Bidirectional synaptic plasticity correlated with the magnitude of dendritic calcium transients above a threshold. , 2001, Journal of neurophysiology.

[3]  Y. Isomura,et al.  Action potential-induced dendritic calcium dynamics correlated with synaptic plasticity in developing hippocampal pyramidal cells. , 1999, Journal of neurophysiology.

[4]  L. Cooper,et al.  A physiological basis for a theory of synapse modification. , 1987, Science.

[5]  E. Bienenstock,et al.  Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[6]  D. Wilkin,et al.  Neuron , 2001, Brain Research.

[7]  L. Cooper,et al.  A unified model of NMDA receptor-dependent bidirectional synaptic plasticity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  G. Bi,et al.  Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type , 1998, The Journal of Neuroscience.

[10]  M. Bear,et al.  Metaplasticity: the plasticity of synaptic plasticity , 1996, Trends in Neurosciences.

[11]  D. Johnston,et al.  A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons , 1997, Science.

[12]  J. Lisman,et al.  A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[13]  L. Abbott,et al.  Competitive Hebbian learning through spike-timing-dependent synaptic plasticity , 2000, Nature Neuroscience.

[14]  H. Markram,et al.  Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs , 1997, Science.

[15]  P. J. Sjöström,et al.  Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity , 2001, Neuron.

[16]  G. Carmignoto,et al.  Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. , 1992, Science.

[17]  R. Nicoll,et al.  Ca2+ Signaling Requirements for Long-Term Depression in the Hippocampus , 1996, Neuron.

[18]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[19]  C. Stevens,et al.  Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  R. Zucker,et al.  Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation. , 1999, Journal of neurophysiology.