MONOCLONAL ANTIBODIES FROM COMBINATORIAL LIBRARIES

[1]  R. Perlmutter,et al.  Autoantibodies and the fetal antibody repertoire. , 1990, International reviews of immunology.

[2]  Andrew D. Griffiths,et al.  By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling , 1992, Bio/Technology.

[3]  R. Myers,et al.  A general method for saturation mutagenesis of cloned DNA fragments. , 1985, Science.

[4]  C. Barbas,et al.  In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  C. Barbas,et al.  Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[6]  C. Barbas,et al.  Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[7]  G. Winter,et al.  Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system. , 1992, Journal of Biological Chemistry.

[8]  D R Burton,et al.  Human combinatorial antibody libraries to hepatitis B surface antigen. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D R Burton,et al.  A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Lerner,et al.  Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[11]  D. Burton.  Antibody: the flexible adaptor molecule. , 1990, Trends in biochemical sciences.

[12]  D R Burton,et al.  Antibodies without immunization. , 1992, Science.

[13]  C. Barbas,et al.  Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[14]  C. Milstein,et al.  The Dynamic Nature of the Antibody Repertoire , 1988, Immunological reviews.

[15]  H R Hoogenboom,et al.  By-passing immunization. Human antibodies from V-gene libraries displayed on phage. , 1991, Journal of molecular biology.

[16]  C. Barbas,et al.  Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[17]  D R Burton,et al.  Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. , 1989, Science.

[18]  R. R. Robinson,et al.  Escherichia coli secretion of an active chimeric antibody fragment. , 1988, Science.

[19]  A. Plückthun,et al.  Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. , 1988, Science.

[20]  G R Pilkington,et al.  Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries. , 1993, Journal of molecular biology.

[21]  D R Burton,et al.  Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[22]  H R Hoogenboom,et al.  By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. , 1992, Journal of molecular biology.

[23]  T. Clackson,et al.  Making antibody fragments using phage display libraries , 1991, Nature.

[24]  G. Winter,et al.  Phage antibodies: filamentous phage displaying antibody variable domains , 1990, Nature.

[25]  R. Schaaper.  Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[26]  R. Kelley,et al.  FAB Assembly and Enrichment in a Monovalent Phage Display System , 1991, Bio/Technology.

[27]  D. Burton,et al.  Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Burton.  Human monoclonal antibodies: achievement and potential. , 1992, Hospital practice.

[29]  H R Hoogenboom,et al.  Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. , 1991, Nucleic acids research.

[30]  G. Winter,et al.  Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D R Burton,et al.  Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. Burton,et al.  Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture. , 1993, Human antibodies and hybridomas.

[33]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[34]  M. Walker,et al.  Isolation and amplification of human IgE Fd encoding mRNA from human peripheral blood lymphocytes. , 1992, Journal of immunological methods.

[35]  D R Burton,et al.  Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  D R Burton,et al.  Human antibodies to HIV-1 by recombinant DNA methods. , 1993, Chemical immunology.

[37]  D R Burton,et al.  A binary plasmid system for shuffling combinatorial antibody libraries. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[38]  K. Fry,et al.  Rapid cloning of rearranged immunoglobulin genes from human hybridoma cells using mixed primers and the polymerase chain reaction. , 1989, Biochemical and biophysical research communications.

[39]  G. P. Smith,et al.  Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. , 1985, Science.

[40]  R. Lerner,et al.  Increasing the chemical potential of the germ-line antibody repertoire. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[41]  C. Barbas,et al.  Immunization of hu-PBL–SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries , 1992, Nature.