论文信息 - Evidence for repair of premutational damage from split X-ray doses.

Evidence for repair of premutational damage from split X-ray doses.

Chinese hamster ovary cells were given two 450-rad doses of X rays separated by 1 or 2 h, during which the cells were held at room temperature to minimize progression through the cell cycle. The frequency of induced mutations to 6-thioguanine resistance was compared with that of mutations induced by a single dose of 450 or 900 rad. Mutation frequencies induced by the split dose were intermediate between those induced by the two single doses, suggesting that premutational lesions were repaired.

R. Painter | R. Jostes

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