Sequence variation database project at the European Bioinformatics Institute

The sequence variation project at EBI aims to create a unified resource for browsing and searching sequence differences. Technical advances in reading in new data types and in validating and cross‐referencing entries are reported. It is suggested that the hardest problems in unifying mutation databases are related to intellectual property rights. The concept of copylefting is introduced as a potential solution to these. Hum Mutat 15:52–56, 2000. © 2000 Wiley‐Liss, Inc.

[1]  P. Argos,et al.  SRS: information retrieval system for molecular biology data banks. , 1996, Methods in enzymology.

[2]  D. Valle,et al.  Online Mendelian Inheritance In Man (OMIM) , 2000, Human mutation.

[3]  S T Sherry,et al.  Use of molecular variation in the NCBI dbSNP database , 2000, Human mutation.

[4]  S. Antonarakis Recommendations for a nomenclature system for human gene mutations , 1998 .

[5]  Floyd E. Bloom,et al.  Opening Science's Compass , 1998, Science.

[6]  Coping with change: Intellectual property rights, new legislation, and the Human Mutation Database Initiative , 2000, Human mutation.

[7]  H. Lehväslaiho,et al.  Guidelines and recommendations for content, structure, and deployment of mutation databases , 1999, Human mutation.

[8]  R. Cotton,et al.  Quality control in the discovery, reporting, and recording of genomic variation , 2000, Human mutation.

[9]  C R Scriver,et al.  Guidelines and recommendations for content, structure, and deployment of mutation databases: II. Journey in progress , 2000, Human mutation.

[10]  S M Maurer,et al.  Database Protection: Is It Broken and Should We Fix It? , 1999, Science.

[11]  R. G. H. Cotton,et al.  The HUGO Mutation Database Initiative , 1998, Science.

[12]  C Béroud,et al.  p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis , 2000, Human mutation.

[13]  Thierry Soussi,et al.  P53 Gene Mutation: Software and Database , 1996, Nucleic Acids Res..

[14]  Patricia Rodriguez-Tomé,et al.  IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools , 1998, Nucleic Acids Res..

[15]  T Etzold,et al.  Unified access to mutation databases. , 1998, Trends in genetics : TIG.