IN­SITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM: AN OVERVIEW

Eye is the most vital organ of body. The usual ophthalmic dosage forms are account for 90% of currently accessible ophthalmic formulations. The major trouble encountered is quick precornel drug loss. To improve ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery systems for ophthalmic administration. Newer research in ophthalmic drug delivery systems is directed towards a amalgamation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. There are various new dosage forms like in­situ gel, collagen shield, minidisc, ocular film, ocusert, nanosuspension, nanoparticulate system, liposomes, niosomes, dendrimers, ocular iontophoresis etc. Conventional delivery systems often result in poor bioavailability and therapeutic response because high tear fluids turn over and dynamics c ause rapid elimination of the drug from the eyes. So, to overcome bioavailability problems, ophthalmic in situ gels were developed.

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