Rationalizing nomenclature for UV doses and effects on humans

The field of atmospheric ultraviolet radiation (UV) research is plagued with difficulties in nomenclature. The problems arise from (a) the strong wavelength dependence of UV radiation received at the Earth?s surface, (b) the ad-hoc way disparate groups have approached the subject and (c) the incorrect use of units when action spectra for different UV effects are incorporated. This report highlights some of the issues, taking vitamin-D synthesis, a beneficial effect, as a specific example. Standard vitamin-D dose (SDD) and minimum vitamin-D dose (MDD) are proposed, analogous to the standard erythema dose (SED) and minimum erythema dose (MED) that are in common use for erythema. In recognition of the fact that currently accepted action spectra may be revised in future if new data become available, it is recommended that spectrally resolved irradiance measurements are maintained and continued so that biologically effective irradiances and doses may be reprocessed.

[1]  Peter Koepke,et al.  Know Your Standard: Clarifying the CIE Erythema Action Spectrum , 2011, Photochemistry and photobiology.

[2]  M. Holick,et al.  Holick's rule and vitamin D from sunlight , 2010, The Journal of Steroid Biochemistry and Molecular Biology.

[3]  William J. Olds Elucidating the links between UV radiation and vitamin D synthesis : using an in vitro model , 2010 .

[4]  V. Fioletov,et al.  Estimated ultraviolet exposure levels for a sufficient vitamin D status in North America. , 2010, Journal of photochemistry and photobiology. B, Biology.

[5]  R. McKenzie,et al.  UV Radiation: Balancing Risks and Benefits † , 2009, Photochemistry and photobiology.

[6]  M. Holick,et al.  Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. , 1988, The Journal of clinical endocrinology and metabolism.

[7]  Richard McKenzie,et al.  Relationship between UVB and erythemally weighted radiation , 2004, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[8]  R. McKenzie,et al.  Serum 25-hydroxyvitamin-D responses to multiple UV exposures from solaria: inferences for exposure to sunlight , 2012, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[9]  Merve Meinhardt-Wollweber,et al.  A computational model for previtamin D(3) production in skin. , 2012, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[10]  V. Fioletov,et al.  On the relationship between erythemal and vitamin D action spectrum weighted ultraviolet radiation. , 2009, Journal of photochemistry and photobiology. B, Biology.

[11]  B L Diffey,et al.  The standard erythema dose: a new photobiological concept , 1997, Photodermatology, photoimmunology & photomedicine.

[12]  Mark Jenkins The UV Advantage , 2004 .

[13]  M. Blumthaler,et al.  Human solar ultraviolet radiant exposure in high mountains , 1988 .

[14]  A. Webb,et al.  Calculated Ultraviolet Exposure Levels for a Healthy Vitamin D Status , 2006, Photochemistry and photobiology.

[15]  J. Rockell,et al.  Serum 25-hydroxyvitamin D concentrations of New Zealanders aged 15 years and older , 2006, Osteoporosis International.

[16]  Knut Stamnes,et al.  Measured UV spectra compared with discrete ordinate method simulations , 1994 .

[17]  L. Björn,et al.  Is the action spectrum for the UV-induced production of previtamin D_3 in human skin correct? , 2010, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[18]  S. Madronich,et al.  Ozone depletion and climate change: impacts on UV radiation , 2014, Photochemical & Photobiological Sciences.

[19]  T. Fitzpatrick The validity and practicality of sun-reactive skin types I through VI. , 1988, Archives of dermatology.

[20]  G. Seckmeyer,et al.  Simultaneous measurement of spectral sky radiance by a non-scanning multidirectional spectroradiometer (MUDIS) , 2013 .

[21]  A. Webb,et al.  The role of sunlight exposure in determining the vitamin D status of the U.K. white adult population , 2010, The British journal of dermatology.

[22]  Maria Zankl,et al.  A Novel Method to Calculate Solar UV Exposure Relevant to Vitamin D Production in Humans , 2013, Photochemistry and photobiology.

[23]  R. Anderson,et al.  Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. , 1982, Science.

[24]  A. Webb,et al.  The Vitamin D Debate: Translating Controlled Experiments into Reality for Human Sun Exposure Times , 2011, Photochemistry and photobiology.

[25]  W. Parnell,et al.  Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 y. , 2005, The Journal of nutrition.

[26]  M. Holick Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health , 2002 .