Inhibitory effect of ricin on the development of preimplantation mouse embryos.

Preimplantation mouse embryos were exposed to ricin, a plant toxin, in vitro and in vivo. The effect was evaluated by morphological observations of the exposed embryos as well as by means of protein synthesis. Ricin was highly toxic to the preimplantation mouse embryo in vitro, the effect being greater on the 2-cell than on the 4-8 cell stage. Intraperitoneal injection of ricin induced a small number of fetuses with exencephaly.

[1]  A. Pihl,et al.  Toxic lectins and related proteins , 1982 .

[2]  N. Lindquist,et al.  A whole body autoradiographic study on the distribution of 14C-labelled di-(2-ethylhexyl)phthalate in mice. , 1982, Toxicology.

[3]  J. Jonsen,et al.  Nickel toxicity in early embryogenesis in mice. , 1981, Toxicology.

[4]  O. Fodstad,et al.  Synergistic effect of adriamycin and ricin on L1210 leukemic cells in mice. , 1980, Cancer research.

[5]  J. Huff,et al.  An evaluation of chemicals and industrial processes associated with cancer in humans based on human and animal data: IARC Monographs Volumes 1 to 20. , 1980, Cancer research.

[6]  O. Fodstad.  Human gastrointestinal cancer grown in nude mice used to test new chemotherapeutic agents. , 1979, Frontiers of gastrointestinal research.

[7]  O. Fodstad,et al.  Toxicity of abrin and ricin in mice and dogs. , 1979, Journal of Toxicology and Environmental Health, Part A.

[8]  Ø. Fodstad,et al.  Effect of ricin and abrin on survival of L1210 leukemic mice and on leukemic and normal bone‐marrow cells , 1978, International journal of cancer.

[9]  A. Pihl,et al.  Abrin and ricin — two toxic lectins , 1978 .

[10]  A Pihl,et al.  Properties and action mechanism of the toxic lectin modeccin: interaction with cell lines resistant to modeccin, abrin, and ricin. , 1978, Journal of supramolecular structure.

[11]  O. Fodstad,et al.  Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. , 1977, Cancer research.

[12]  G. Chernoff.  The fetal alcohol syndrome in mice: an animal model. , 1977, Teratology.

[13]  A. Pihl,et al.  Abrin, Ricin, and their Associated Agglutinins , 1977 .

[14]  O. Fodstad,et al.  Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. , 1976, British Journal of Cancer.

[15]  J. Skorve,et al.  On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit. , 1975, European journal of biochemistry.

[16]  M Slavik,et al.  Quantitative prediction of drug toxicity in humans from toxicology in small and large animals. , 1975, Cancer research.

[17]  D. Whittingham.  Embryo banks in the future of developmental genetics. , 1974, Genetics.

[18]  A. Pihl,et al.  Mechanism of action of the toxic lectins abrin and ricin , 1974, Nature.

[19]  G A Balint,et al.  Ricin: the toxic protein of castor oil seeds. , 1974, Toxicology.

[20]  F. Stirpe,et al.  Inhibition by ricin of protein synthesis in vitro: 60S ribosomal subunit as the target of the toxin (Short Communication) , 1973 .

[21]  F. Stirpe,et al.  Inhibition by ricin of protein synthesis in vitro. Ribosomes as the target of the toxin. , 1973, The Biochemical journal.

[22]  A. Pihl,et al.  Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. , 1973, Biochemistry.

[23]  Whittingham Dg.  Culture of mouse ova. , 1971 .

[24]  K. Tserng,et al.  Effect of crystalline ricin on the biosynthesis of protein, RNA, and DNA in experimental tumor cells. , 1970, Cancer research.

[25]  K. Tserng,et al.  Abrin and Ricin: New Anti-tumour Substances , 1970, Nature.

[26]  J. Warkany,et al.  Experimental production of congenital malformations in rats by salicylate poisoning. , 1959, The American journal of pathology.