Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes.

[1]  Huanjun Chen,et al.  In vitro effect of CTAB- and PEG-coated gold nanorods on the induction of eryptosis/erythroptosis in human erythrocytes , 2012, Nanotoxicology.

[2]  F. Lang,et al.  Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene , 2012, Journal of cellular and molecular medicine.

[3]  K. Roby,et al.  Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A. , 2012, Gynecologic oncology.

[4]  S. Kong,et al.  Polyphyllin D induces apoptosis in human erythrocytes through Ca2+ rise and membrane permeabilization , 2012, Archives of Toxicology.

[5]  O. Borst,et al.  Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX. , 2012, American journal of physiology. Cell physiology.

[6]  B. Maček,et al.  Protein Kinase CK1α Regulates Erythrocyte Survival , 2012, Cellular Physiology and Biochemistry.

[7]  C. De Felice,et al.  Erythrocyte caspase-3 activation and oxidative imbalance in erythrocytes and in plasma of type 2 diabetic patients , 2013, Acta Diabetologica.

[8]  A. Marcus,et al.  Withaferin A inhibits breast cancer invasion and metastasis at sub‐cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation , 2011, International journal of cancer.

[9]  F. Lang,et al.  p38 MAPK Activation and Function following Osmotic Shock of Erythrocytes , 2011, Cellular Physiology and Biochemistry.

[10]  E. S. Yang,et al.  Combination of withaferin A and X-ray irradiation enhances apoptosis in U937 cells. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[11]  F. Lang,et al.  Dicoumarol Activates Ca2+-permeable Cation Channels Triggering Erythrocyte Cell Membrane Scrambling , 2011, Cellular Physiology and Biochemistry.

[12]  G. Gusev,et al.  Fluoride-induced death of rat erythrocytes in vitro. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[13]  Ramesh C. Gupta,et al.  Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. , 2011, Carcinogenesis.

[14]  Xuan Zhang,et al.  Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cells , 2011, BMC complementary and alternative medicine.

[15]  B. Van Houten,et al.  Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species , 2011, PloS one.

[16]  F. Lang,et al.  Sphingosine but not Sphingosine-1-phosphate Stimulates Suicidal Erythrocyte Death , 2011, Cellular Physiology and Biochemistry.

[17]  F. Lang,et al.  Stimulation of Suicidal Erythrocyte Death by Benzethonium , 2011, Cellular Physiology and Biochemistry.

[18]  Shivendra V. Singh,et al.  Withaferin a suppresses estrogen receptor‐α expression in human breast cancer cells , 2011, Molecular carcinogenesis.

[19]  B. Debuire,et al.  Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2 , 2011, Apoptosis.

[20]  F. Lang,et al.  Janus Kinase 3 is Expressed in Erythrocytes, Phosphorylated Upon Energy Depletion and Involved in the Regulation of Suicidal Erythrocyte Death , 2011, Cellular Physiology and Biochemistry.

[21]  K. M. Felder,et al.  Hemotrophic Mycoplasmas Induce Programmed Cell Death in Red Blood Cells , 2011, Cellular Physiology and Biochemistry.

[22]  M. Rodríguez-Moran,et al.  Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease , 2011, Molecular and Cellular Biochemistry.

[23]  E. Park,et al.  Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[24]  T. Kwon,et al.  Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. , 2011, Chemico-biological interactions.

[25]  M. Schaller,et al.  The NFĸB Pathway Inhibitors Bay 11-7082 and Parthenolide Induce Programmed Cell Death in Anucleated Erythrocytes , 2011, Cellular Physiology and Biochemistry.

[26]  F. Lang,et al.  Stimulation of Suicidal Erythrocyte Death by α-Lipoic Acid , 2011, Cellular Physiology and Biochemistry.

[27]  V. Bisaria,et al.  Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A , 2010, BMC Genomics.

[28]  V. Bisaria,et al.  Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes , 2010, BMC Genomics.

[29]  Shivendra V. Singh,et al.  Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. , 2010, Carcinogenesis.

[30]  E. Schuchman,et al.  Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice , 2010, Cellular Physiology and Biochemistry.

[31]  F. Lang,et al.  FTY720-Induced Suicidal Erythrocyte Death , 2010, Cellular Physiology and Biochemistry.

[32]  B. Timmermann,et al.  Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma. , 2010, Journal of natural products.

[33]  F. Lang,et al.  Effect of Amphotericin B on Parasitemia and Survival of Plasmodium Berghei-infected Mice , 2010, Cellular Physiology and Biochemistry.

[34]  M. Quintanar-Escorza,et al.  Oxidative damage increases intracellular free calcium [Ca2+]i concentration in human erythrocytes incubated with lead. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[35]  F. Lang,et al.  Effect of Anandamide in Plasmodium Berghei-infected Mice , 2010, Cellular Physiology and Biochemistry.

[36]  Yang Zhang,et al.  Ceramide in Redox Signaling and Cardiovascular Diseases , 2010, Cellular Physiology and Biochemistry.

[37]  Yang Zhang,et al.  Ceramide in Pseudomonas aeruginosa Infections and Cystic Fibrosis , 2010, Cellular Physiology and Biochemistry.

[38]  W. Kuebler,et al.  Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature , 2010, Cellular Physiology and Biochemistry.

[39]  K. Fassbender,et al.  Spingolipids in Multiple Sclerosis , 2010, Cellular Physiology and Biochemistry.

[40]  J. Kornhuber,et al.  Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications , 2010, Cellular Physiology and Biochemistry.

[41]  F. Lang,et al.  Ceramide in Suicidal Death of Erythrocytes , 2010, Cellular Physiology and Biochemistry.

[42]  Tao Zhang,et al.  Withaferin A targets heat shock protein 90 in pancreatic cancer cells. , 2010, Biochemical pharmacology.

[43]  C. Damodaran,et al.  Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis , 2010, Molecular Cancer Therapeutics.

[44]  S. M. de la Monte,et al.  Insulin resistance and Alzheimer's disease. , 2009, BMB reports.

[45]  H. J. Um,et al.  Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. , 2009, Free radical biology & medicine.

[46]  E. Schleicher,et al.  Regulation of erythrocyte survival by AMP‐activated protein kinase , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[47]  M. Mirjalili,et al.  Genetic and Withaferin A Analysis of Iranian Natural Populations of Withania Somnifera and W. Coagulans by RAPD and HPTLC , 2009, Natural product communications.

[48]  Xiongwei Zhu,et al.  Insulin is a two-edged knife on the brain. , 2009, Journal of Alzheimer's disease : JAD.

[49]  O. Pappo,et al.  Beta-glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat. , 2009, American journal of physiology. Endocrinology and metabolism.

[50]  R. Maitra,et al.  Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation , 2009, Journal of Inflammation.

[51]  D. Zappulla Environmental stress, erythrocyte dysfunctions, inflammation, and the metabolic syndrome: adaptations to CO2 increases? , 2008, Journal of the cardiometabolic syndrome.

[52]  H. Lerche,et al.  Eryptosis, a Window to Systemic Disease , 2008, Cellular Physiology and Biochemistry.

[53]  Yung-Hyun Choi,et al.  Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation , 2008, Apoptosis.

[54]  R. Sangwan,et al.  Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade , 2008, Apoptosis.

[55]  Shivendra V. Singh,et al.  Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. , 2008, Cancer research.

[56]  F. Hofmann,et al.  Anemia and splenomegaly in cGKI-deficient mice , 2008, Proceedings of the National Academy of Sciences.

[57]  Jeong-Yeh Yang,et al.  Withaferin A induces apoptosis and inhibits adipogenesis in 3T3‐L1 adipocytes , 2008, BioFactors.

[58]  S. Summers,et al.  Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. , 2008, Endocrine reviews.

[59]  F. Lang,et al.  TRPC6 Contributes to the Ca2+ Leak of Human Erythrocytes , 2008, Cellular Physiology and Biochemistry.

[60]  S. Bhushan,et al.  Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine , 2007, Apoptosis.

[61]  Chang-Guo Zhan,et al.  The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. , 2007, Chemistry & biology.

[62]  A. Verkhratsky,et al.  Insulin‐like growth factor‐1‐dependent maintenance of neuronal metabolism through the phosphatidylinositol 3‐kinase–Akt pathway is inhibited by C2‐ceramide in CAD cells , 2007, The European journal of neuroscience.

[63]  Seng H. Cheng,et al.  Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes , 2007, Diabetes.

[64]  S. Pramanik,et al.  Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I–DNA complex , 2007, Cell Death and Differentiation.

[65]  Guoqing Shi,et al.  The Tumor Proteasome Is a Primary Target for the Natural Anticancer Compound Withaferin A Isolated from “Indian Winter Cherry” , 2007, Molecular Pharmacology.

[66]  H. Hefter,et al.  Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide , 2007, Nature Medicine.

[67]  J. Chung,et al.  Lysophosphatidic Acid Induces Thrombogenic Activity Through Phosphatidylserine Exposure and Procoagulant Microvesicle Generation in Human Erythrocytes , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[68]  D. Chendil,et al.  Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. , 2007, Cancer research.

[69]  F. Lang,et al.  Monensin Induced Suicidal Erythrocyte Death , 2006, Cellular Physiology and Biochemistry.

[70]  P. Comfurius,et al.  Surface exposure of phosphatidylserine in pathological cells , 2005, Cellular and Molecular Life Sciences CMLS.

[71]  Devi Pu Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization. , 1996 .