The Quinolones and Dermatologic Practice

Dermatologists have always been interested in chemotherapeutic agents, as the skin provides a visible means for evaluating a new modality. From the empiric use of mercurials in the treatment of syphilis to the scientific discovery of 606 by Paul Ehrlich (1854-1915), anti-infective drugs have played a significant part in dermatologic practice.' A half century ago, the use of the aniline dyes, which had allowed Paul Gerson Unna (1850-1929) and other pioneer dermatologists to create the discipline of dermatopathology, initiated a new era when Gerhard Domagk (1895-1964) discovered the antibacterial qualities of prontosil, and the sulfonamides became the wonder drugs of the 1930s.̂ For the first time, bacterial infections could be readily controlled. A diagnosis of impetigo or ecthyma did not have to foretell an ominous ending.

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