ANTI-ENDOTOXIC ACTIVITY OF CORTICOSTEROIDS

A method for assaying corticosteroid activity based on the protection against the lethal action of bacterial endotoxin has been developed. Linear relationships between survival and dose of endotoxin were observed when a mixture of endotoxin and steroid were given intracardially to adrenalectomized rats. pThe relative activities of corticosteroids in protecting against endotoxins are different from their apparent anti-inflammatory activities.