Minor groove binders as anti-infective agents.
暂无分享,去创建一个
[1] D. Nathwani,et al. Results from the second Scottish national prevalence survey: the changing epidemiology of healthcare-associated infection in Scotland. , 2012, The Journal of hospital infection.
[2] M. Barrett,et al. Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes , 2012, Proceedings of the National Academy of Sciences.
[3] R. Aphasizhev,et al. Mitochondrial RNA processing in trypanosomes. , 2011, Research in microbiology.
[4] Sunil K. Vooturi,et al. Examination of a synthetic benzophenone membrane-targeted antibiotic. , 2011, Organic & biomolecular chemistry.
[5] D. Boykin,et al. Novel Diamidines with Activity against Babesia divergens In Vitro and Babesia microti In Vivo , 2011, Antimicrobial Agents and Chemotherapy.
[6] D. Thurston,et al. Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs). , 1994, Chemical reviews.
[7] W. Wilson,et al. Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide. , 2010, Bioorganic & medicinal chemistry.
[8] M. Barrett,et al. Diamidines for human African trypanosomiasis. , 2010, Current opinion in investigational drugs.
[9] C. Galmarini,et al. A Review of Trabectedin (ET-743): A Unique Mechanism of Action , 2010, Molecular Cancer Therapeutics.
[10] A. Ivanov,et al. Minor groove dimeric bisbenzimidazoles inhibit in vitro DNA binding to eukaryotic DNA topoisomerase I , 2010, Biochemistry (Moscow).
[11] R. Reeves,et al. Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia , 2010, PLoS ONE.
[12] M. Kris,et al. A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors , 2010, Cancer Chemotherapy and Pharmacology.
[13] A. Thompson,et al. The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links. , 2009, Journal of the American Chemical Society.
[14] S. Vooturi,et al. Design, synthesis, and structure-activity relationships of benzophenone-based tetraamides as novel antibacterial agents. , 2009, Journal of medicinal chemistry.
[15] D. Boykin,et al. New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289 , 2009, Antimicrobial Agents and Chemotherapy.
[16] S. Mackay,et al. A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity. , 2009, Organic & biomolecular chemistry.
[17] M. Grant,et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. , 2009, The Biochemical journal.
[18] W. Wilson,et al. Heterocyclic diamidine interactions at AT base pairs in the DNA minor groove: effects of heterocycle differences, DNA AT sequence and length. , 2008, Journal of Physical Chemistry B.
[19] Colin J. Suckling,et al. Molecular recognition and physicochemical properties in the discovery of selective antibacterial minor groove binders , 2008 .
[20] W. Wilson,et al. Antiparasitic compounds that target DNA. , 2008, Biochimie.
[21] R. Mantovani,et al. Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78 , 2008, Molecular Cancer Therapeutics.
[22] P. Peixoto,et al. Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication , 2008, Nucleic acids research.
[23] L. Purcell,et al. Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent. , 2008, The Journal of infectious diseases.
[24] X. Xi,et al. Inhibition of DNA helicase, ATPase and DNA-binding activities of E. coli RecQ helicase by chemotherapeutic agents. , 2007, Journal of biochemistry.
[25] S. Meshnick,et al. The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei , 2007, Antimicrobial Agents and Chemotherapy.
[26] Jean-Jacques Helesbeux,et al. Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. , 2007, Journal of medicinal chemistry.
[27] J. Blay,et al. Brostallicin, an agent with potential activity in metastatic soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. , 2007, European journal of cancer.
[28] D. Hochhauser,et al. Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells. , 2006, Bioorganic & medicinal chemistry letters.
[29] D. Boykin,et al. CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime] , 2006, Drug Metabolism and Disposition.
[30] V. Alibu,et al. Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance , 2006, Molecular Pharmacology.
[31] A. Schnaufer,et al. The F1‐ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function , 2005, The EMBO journal.
[32] S. Meshnick,et al. Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections. , 2005, The Journal of infectious diseases.
[33] A. Sinyakov,et al. Interaction of HIV-1 Reverse Transcriptase with New Minor Groove Binders and Their Conjugates with Oligonucleotides , 2005, Molecular Biology.
[34] S. Mackay,et al. Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole. , 2004, Journal of the American Chemical Society.
[35] R. Waigh,et al. Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. , 2004, Journal of medicinal chemistry.
[36] R. Bürli,et al. DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives. , 2004, Bioorganic & medicinal chemistry letters.
[37] R. Bürli,et al. Pharmacology of Novel Heteroaromatic Polycycle Antibacterials , 2003, Antimicrobial Agents and Chemotherapy.
[38] P. Dervan,et al. Accessibility of nuclear chromatin by DNA binding polyamides. , 2003, Chemistry & biology.
[39] Michael P Barrett,et al. Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. , 2003, Trends in parasitology.
[40] R. Bürli,et al. In Vitro Antimicrobial Activity of GSQ1530, a New Heteroaromatic Polycyclic Compound , 2002, Antimicrobial Agents and Chemotherapy.
[41] A. Schnaufer,et al. Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA. , 2002, International journal for parasitology.
[42] J. Lown,,et al. Design and synthesis of new thiazolated cross-linked DNA binding polyamides for altered sequence recognition , 2002 .
[43] M. Broggini,et al. Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione. , 2002, Cancer research.
[44] Uli Schmitz,et al. Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant Enterococci [corrected] and methicillin resistant Staphylococcus aureus. , 2002, Journal of medicinal chemistry.
[45] P. Dervan,et al. Molecular recognition of DNA by small molecules. , 2001, Bioorganic & medicinal chemistry.
[46] K. Luger,et al. Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides. , 2001, Journal of molecular biology.
[47] A. Stead,et al. Diamidine compounds: selective uptake and targeting in Plasmodium falciparum. , 2001, Molecular pharmacology.
[48] J. Perfect,et al. Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents. , 2001, Journal of medicinal chemistry.
[49] H. D. de Koning. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. , 2001, Molecular pharmacology.
[50] M. Avison,et al. Interscience Conference on Antimicrobial Agents and Chemotherapy , 2001 .
[51] M. Del Poeta,et al. In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles , 1998, Antimicrobial Agents and Chemotherapy.
[52] M. Del Poeta,et al. Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents , 1998, Antimicrobial Agents and Chemotherapy.
[53] Y. Pommier,et al. Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase. , 1998, Molecular pharmacology.
[54] J. Trauger,et al. Recognition of DNA by designed ligands at subnanomolar concentrations , 1996, Nature.
[55] S Neidle,et al. A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity. , 1995, Biochemistry.
[56] A. Fairlamb,et al. Uptake of Diamidine Drugs by the P2 Nucleoside Transporter in Melarsen-sensitive and -resistant Trypanosoma brucei brucei(*) , 1995, The Journal of Biological Chemistry.
[57] A. Abu-daya,et al. DNA sequence preferences of several AT-selective minor groove binding ligands. , 1995, Nucleic acids research.
[58] R. Kiser,et al. Novel sulfonated and phosphonated analogs of distamycin which inhibit the replication of HIV. , 1995, Antiviral research.
[59] M. Barrett,et al. A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity. , 1995, Molecular and biochemical parasitology.
[60] D E Wemmer,et al. Design of a G.C-specific DNA minor groove-binding peptide. , 1994, Science.
[61] A. Peregrine,et al. Pharmacology of diminazene: a review. , 1993, Acta tropica.
[62] J. Hall,et al. Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures , 1991, Antimicrobial Agents and Chemotherapy.
[63] J. Hall,et al. Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity , 1991, Antimicrobial Agents and Chemotherapy.
[64] T. Shapiro,et al. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[65] R. D'Alessio,et al. Synthesis, DNA-binding properties, and antitumor activity of novel distamycin derivatives. , 1989, Journal of medicinal chemistry.
[66] M. Kron,et al. Pentamidine: a review. , 1985, Reviews of infectious diseases.
[67] S. Kuentzel,et al. CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism. , 1978, The Journal of antibiotics.
[68] D. McLaren,et al. Effects of DAPI a new diamidine trypanocide, on the ultrastructure of Trypanosoma rhodesiense. , 1978, Transactions of the Royal Society of Tropical Medicine and Hygiene.
[69] W. Leimgruber,et al. The structure of anthramycin. , 1965, Journal of the American Chemical Society.
[70] A. C. Finlay,et al. Netropsin, a New Antibiotic Produced by a Streptomyces , 1951 .