Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains.

[1]  T. Emery Initial steps in the biosynthesis of ferrichrome. Incorporation of delta-N-hydroxyornithine and delta-N-acetyl-delta-N-hydroxyornithine. , 1966, Biochemistry.

[2]  S. Laland,et al.  Gramicidin S synthetase, an enzyme with an unusually large number of catalytic functions. , 1972, Nature: New biology.

[3]  S. Laland,et al.  The protein thiotemplate mechanism of synthesis for the peptide antibiotics produced by Bacillus brevis. , 1973, Essays in biochemistry.

[4]  Laland Sg,et al.  The protein thiotemplate mechanism of synthesis for the peptide antibiotics produced by Bacillus brevis. , 1973 .

[5]  F. Lipmann Nonribosomal polypeptide synthesis on polyenzyme templates , 1973 .

[6]  K. Kurahashi Biosynthesis of small peptides. , 1974, Annual review of biochemistry.

[7]  Substrate specificity of the amino acyl adenylate activation sites of gramicidin S-synthetase (GSS). , 1975, Acta microbiologica Academiae Scientiarum Hungaricae.

[8]  J. Vater,et al.  Gramicidin S-synthetase. A further characterization of phenylalanine racemase, the light enzyme of gramicidin s-synthetase. , 1976, Biochimica et biophysica acta.

[9]  M. Marahiel,et al.  Molecular cloning of an ornithine-activating fragment of the gramicidin S synthetase 2 gene from Bacillus brevis and its expression in Escherichia coli , 1985, Journal of bacteriology.

[10]  S. Iwasaki,et al.  Biosynthetic studies on saframycin A, a quinone antitumor antibiotic produced by Streptomyces lavendulae. , 1985, The Journal of biological chemistry.

[11]  U. Keller Actinomycin synthetases. Multifunctional enzymes responsible for the synthesis of the peptide chains of actinomycin. , 1987, The Journal of biological chemistry.

[12]  Cell-Free Biosynthesis of Nocardicin A from Nocardicin E and S-Adenosylmethionine , 1988 .

[13]  C. Townsend,et al.  The role of nocardicin G in nocardicin A biosynthesis , 1988 .

[14]  S. Leong,et al.  Analysis of ferrichrome biosynthesis in the phytopathogenic fungus Ustilago maydis: cloning of an ornithine-N5-oxygenase gene , 1989, Journal of bacteriology.

[15]  J. Nielsen,et al.  Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation. , 1991, Biochemistry.

[16]  Y. Yamamoto,et al.  The nucleotide sequence for a proline-activating domain of gramicidin S synthetase 2 gene from Bacillus brevis. , 1991, Journal of biochemistry.

[17]  M. Marahiel,et al.  Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes , 1992, Molecular microbiology.

[18]  C. Walsh,et al.  Characterization of EntF as a serine‐activating enzyme , 1992, Protein science : a publication of the Protein Society.

[19]  D. Sinderen,et al.  Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis , 1993, Molecular microbiology.

[20]  R. Nogarotto,et al.  Characterization of the surfactin synthetase multi-enzyme complex. , 1994, Biochimica et biophysica acta.

[21]  D. Gross,et al.  Analysis of the syrB and syrC genes of Pseudomonas syringae pv. syringae indicates that syringomycin is synthesized by a thiotemplate mechanism , 1995, Journal of bacteriology.

[22]  T. Stachelhaus,et al.  Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. , 1995, Science.

[23]  C Ratledge,et al.  Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis. , 1995, The Biochemical journal.

[24]  L. Vining,et al.  Genetics and biochemistry of antibiotic production. , 1994, Biotechnology.

[25]  T. Stachelhaus,et al.  Modular Structure of Peptide Synthetases Revealed by Dissection of the Multifunctional Enzyme GrsA (*) , 1995, The Journal of Biological Chemistry.

[26]  H. von Döhren,et al.  Characterization of tyrocidine synthetase 1 (TY1): requirement of posttranslational modification for peptide biosynthesis. , 1995, Biochemistry.

[27]  T. Stein,et al.  The Multiple Carrier Model of Nonribosomal Peptide Biosynthesis at Modular Multienzymatic Templates* , 1996, The Journal of Biological Chemistry.

[28]  A. Pospiech,et al.  Two multifunctional peptide synthetases and an O-methyltransferase are involved in the biosynthesis of the DNA-binding antibiotic and antitumour agent saframycin Mx1 from Myxococcus xanthus. , 1996, Microbiology.

[29]  G. Grandi,et al.  Engineering of Peptide Synthetases , 1997, The Journal of Biological Chemistry.

[30]  P. Brick,et al.  Structural basis for the activation of phenylalanine in the non‐ribosomal biosynthesis of gramicidin S , 1997, The EMBO journal.

[31]  M. Marahiel,et al.  The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains , 1997, Journal of bacteriology.

[33]  Christopher J. Schofield,et al.  The Mechanism of ACV Synthetase. , 1997, Chemical reviews.

[34]  Mohamed A. Marahiel,et al.  Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis. , 1997, Chemical reviews.

[35]  J. Thompson,et al.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. , 1997, Nucleic acids research.

[36]  W. Saurin,et al.  Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene , 1997, Antimicrobial agents and chemotherapy.

[37]  J. Vater,et al.  Multifunctional Peptide Synthetases. , 1997, Chemical reviews.

[38]  Leonard Katz,et al.  Manipulation of Modular Polyketide Synthases. , 1997, Chemical reviews.

[39]  W. Saenger,et al.  Substrate Specificity of Hybrid Modules from Peptide Synthetases* , 1997, The Journal of Biological Chemistry.

[40]  T. Stachelhaus,et al.  Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping , 1998, Molecular and General Genetics MGG.

[41]  W. Jacobs,et al.  Analysis of the Exochelin Locus inMycobacterium smegmatis: Biosynthesis Genes Have Homology with Genes of the Peptide Synthetase Family , 1998, Journal of bacteriology.

[42]  G. Grandi,et al.  Characterization of the Syringomycin Synthetase Gene Cluster , 1998, The Journal of Biological Chemistry.

[43]  Guang-Huey Lin,et al.  Molecular Cloning and Characterization of Fengycin Synthetase Gene fenB from Bacillus subtilis , 1998, Journal of bacteriology.

[44]  C. Walsh,et al.  The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. , 1998, Biochemistry.

[45]  P. Leadlay,et al.  Mutational Biosynthesis of Novel Rapamycins by a Strain of Streptomyces hygroscopicus NRRL 5491 Disrupted inrapL, Encoding a Putative Lysine Cyclodeaminase , 1998, Journal of bacteriology.

[46]  D. Cane,et al.  Dissecting and exploiting intermodular communication in polyketide synthases. , 1999, Science.

[47]  Alcino J. Silva,et al.  Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel ‘ ‘ unnatural ’ ’ natural products , 1999 .

[48]  T. Stachelhaus,et al.  Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis. , 1999, Science.

[49]  M. Marahiel,et al.  Molecular and Biochemical Characterization of the Protein Template Controlling Biosynthesis of the Lipopeptide Lichenysin , 1999, Journal of bacteriology.

[50]  B. Shen,et al.  Bleomycin Biosynthesis inStreptomyces verticillusATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis☆☆☆★ , 1999 .

[51]  T. Stein,et al.  Structural and functional organization of the fengycin synthetase multienzyme system from Bacillus subtilis b213 and A1/3. , 1999, Chemistry & biology.

[52]  M. Marahiel,et al.  How do peptide synthetases generate structural diversity? , 1999, Chemistry & biology.

[53]  T. Stachelhaus,et al.  The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. , 1999, Chemistry & biology.

[54]  T. Jukes,et al.  The neutral theory of molecular evolution. , 2000, Genetics.