Rapid access to enantiopure bupropion and its major metabolite by stereospecific nucleophilic substitution on an α-ketotriflate
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C. Senanayake | Z. Han | Q. K. Fang | S. Wald | P. Grover | Donald W. Kessler | Q. Fang
[1] B. Cooper,et al. Synthesis, stereochemistry and anti‐tetrabenazine activity of bicyclo analogues of 2‐phenylmorpholines , 1997 .
[2] T. Cooper,et al. Enantiomeric determination of the phenylmorpholinol metabolite of bupropion in human plasma using coupled achiral-chiral liquid chromatography. , 1997, Biomedical chromatography : BMC.
[3] G. Coppola,et al. α-hydroxy acids in enantioselective syntheses , 1997 .
[4] B. Cooper,et al. (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake. , 1996, Journal of medicinal chemistry.
[5] K. Sharpless,et al. .alpha.-Hydroxy ketones in high enantiomeric purity from asymmetric dihydroxylation of enol ethers , 1992 .
[6] X. Creary. Competing kc, borderline, ks, and carbonyl addition processes in solvolyses of .alpha.-keto mesylates and triflates. .alpha.-Keto cations. 5 , 1984 .
[7] G. Blaschke,et al. Kinetics of racemization of (+)- and (-)-diethylpropion: studies in aqueous solution, with and without the addition of cyclodextrins, in organic solvents and in human plasma. , 1998, Chirality.
[8] D. H. Schroeder,et al. Pharmacological significance of the species differences in bupropion metabolism. , 1987, Xenobiotica; the fate of foreign compounds in biological systems.