Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells.

[1]  Sven Diederichs,et al.  The hallmarks of cancer , 2012, RNA biology.

[2]  S. Kelley,et al.  Mitochondria‐Penetrating Peptides: Sequence Effects and Model Cargo Transport , 2009, Chembiochem : a European journal of chemical biology.

[3]  S. Kelley,et al.  Engineered apoptosis-inducing peptides with enhanced mitochondrial localization and potency. , 2009, Journal of medicinal chemistry.

[4]  S. Kelley,et al.  Mitochondria-penetrating peptides. , 2008, Chemistry & biology.

[5]  Rebecca C Taylor,et al.  Apoptosis: controlled demolition at the cellular level , 2008, Nature Reviews Molecular Cell Biology.

[6]  S. Kelley,et al.  Cyanine dye conjugates as probes for live cell imaging. , 2007, Bioorganic & medicinal chemistry letters.

[7]  L. Scorrano,et al.  Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts , 2007, Nature Protocols.

[8]  B. Van Houten,et al.  Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death* , 2003, The Journal of Biological Chemistry.

[9]  J. Wilce,et al.  Targeting large molecules to mitochondria. , 2001, Advanced drug delivery reviews.

[10]  J. Modica-Napolitano,et al.  Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. , 2001, Advanced drug delivery reviews.

[11]  R. Flavell,et al.  GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. , 2001, Immunity.

[12]  S. Lowe,et al.  Apoptosis in cancer. , 2000, Carcinogenesis.

[13]  Kendall A. Smith,et al.  Cytokine response gene 6 induces p21 and regulates both cell growth and arrest , 1999, Oncogene.

[14]  B. Van Houten,et al.  Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu. , 1999, Biochemical pharmacology.

[15]  U. Lakshmipathy,et al.  The Human DNA Ligase III Gene Encodes Nuclear and Mitochondrial Proteins , 1999, Molecular and Cellular Biology.

[16]  C. Pepper,et al.  Chlorambucil resistance in B‐cell chronic lymphocytic leukaemia is mediated through failed Bax induction and selection of high Bcl‐2‐expressing subclones , 1999, British journal of haematology.

[17]  John C Reed,et al.  Bcl-2 family proteins , 1998, Oncogene.

[18]  J. Johnston,et al.  Chlorambucil in chronic lymphocytic leukemia: mechanism of action. , 1996, Leukemia & lymphoma.

[19]  A. Fornace,et al.  Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. , 1996, Mutation research.

[20]  J. Modica-Napolitano,et al.  Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077. , 1996, Cancer research.

[21]  C. Rudin,et al.  Expression of bcl-xL can confer a multidrug resistance phenotype. , 1995, Blood.

[22]  R. Souhami,et al.  The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid. , 1992, Biochemical pharmacology.

[23]  J. Johnston,et al.  Role of glutathione and glutathione S-transferase in chlorambucil resistance. , 1992, Molecular pharmacology.

[24]  J. H. Kim,et al.  4-(4-nitrobenzyl)pyridine tests for alkylating agents following chemical oxidative activation , 1992 .

[25]  J. Modica-Napolitano,et al.  Basis for the selective cytotoxicity of rhodamine 123. , 1987, Cancer research.

[26]  T. Lampidis,et al.  Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. , 1985, The Journal of biological chemistry.

[27]  J. Till,et al.  COLONY ASSAY FOR PROLIFERATIVE BLAST CELLS CIRCULATING IN MYELOBLASTIC LEUKÆMIA , 1977, The Lancet.

[28]  B. Van Houten,et al.  Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. , 2006, Methods in molecular biology.

[29]  W. Lehmann,et al.  Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. , 1998, British Journal of Cancer.

[30]  J. Mccormick Letter: Emigration and mental subnormality in Northern Ireland. , 1974, Lancet.