IgG removal significantly enhances detection of microarray allergen‐specific IgE reactivity in patients' serum

To the Editor, Allergen multiplex (AM) investigation is an excellent research tool and is now getting more importance in clinical practice.1 AM miniaturization using limited amounts of each allergen suggested competition between IgE and IgG, but data in humans are scarce.2,3 We investigated the effect of IgG depletion on specific (s) IgE levels measured with two AM. First, protein G was used to remove IgG from DOI: 10.1111/all.14536

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