Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia

[1]  K. Hongo,et al.  Adolescent PR3-ANCA-positive hypertrophic pachymeningitis , 2018, Medicine.

[2]  G. Bein,et al.  Antiendothelial &agr;v&bgr;3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia , 2016, Arteriosclerosis, thrombosis, and vascular biology.

[3]  G. Acharya,et al.  Maternal anti-HLA class I antibodies are associated with reduced birth weight in thrombocytopenic neonates. , 2016, Journal of reproductive immunology.

[4]  Conglei Li,et al.  Fetal and neonatal alloimmune thrombocytopenia. , 2016, Seminars in fetal & neonatal medicine.

[5]  M. Farghali,et al.  Relationship between uterine natural killer cells and unexplained repeated miscarriage. , 2015, Journal of the Turkish German Gynecological Association.

[6]  J. Strominger,et al.  The HLA-G cycle provides for both NK tolerance and immunity at the maternal–fetal interface , 2015, Proceedings of the National Academy of Sciences.

[7]  B. Curtis.  Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune thrombocytopenia , 2015, British journal of haematology.

[8]  S. Lye,et al.  Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy , 2015, Cellular and Molecular Immunology.

[9]  J. Freedman,et al.  Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia , 2015, Nature Communications.

[10]  H. Ni,et al.  Angiogenesis and bleeding disorders in FNAIT , 2015, Oncotarget.

[11]  J. Freedman,et al.  Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. , 2015, The Journal of clinical investigation.

[12]  Judith E. Cartwright,et al.  Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia , 2014, Journal of leukocyte biology.

[13]  B. Croy,et al.  Uterine natural killer cells: supervisors of vasculature construction in early decidua basalis. , 2014, Reproduction.

[14]  S. Young,et al.  Characterization of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis , 2014, American journal of reproductive immunology.

[15]  N. Freitag,et al.  Influence of relative NK–DC abundance on placentation and its relation to epigenetic programming in the offspring , 2014, Cell Death and Disease.

[16]  S. Lye,et al.  Leukocyte driven-decidual angiogenesis in early pregnancy , 2014, Cellular and Molecular Immunology.

[17]  S. Rajagopalan.  HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction , 2014, Cellular and Molecular Immunology.

[18]  A. Moffett,et al.  MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling , 2014, Nature Communications.

[19]  Judith E. Cartwright,et al.  Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. , 2013, The American journal of pathology.

[20]  A. Sharkey,et al.  Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation. , 2013, The Journal of clinical investigation.

[21]  J. Freedman,et al.  Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia , 2013, Thrombosis and Haemostasis.

[22]  P. Arck,et al.  Fetomaternal immune cross-talk and its consequences for maternal and offspring's health , 2013, Nature Medicine.

[23]  A. David,et al.  Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry , 2013, BMJ Open.

[24]  A. Coffey,et al.  Neonatal Alloimmune Thrombocytopenia Associated with Massive Chronic Intervillositis: A Case Report and Review of the Literature , 2013, Pediatric and Developmental Pathology.

[25]  Zhigang Tian,et al.  Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal–fetal interface , 2012, Proceedings of the National Academy of Sciences.

[26]  P. Baker,et al.  Uterine natural killer cells initiate spiral artery remodeling in human pregnancy , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  S. Bainbridge,et al.  Endothelial Nitric Oxide Synthase Deficiency Reduces Uterine Blood Flow , Spiral Artery Elongation , and Placental Oxygenation in Pregnant Mice , 2012 .

[28]  H. Ni,et al.  Toward a prophylaxis against fetal and neonatal alloimmune thrombocytopenia: induction of antibody‐mediated immune suppression and prevention of severe clinical complications in a murine model , 2012, Transfusion.

[29]  J. Freedman,et al.  The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. , 2011, The Journal of clinical investigation.

[30]  F. Hsieh,et al.  MUC1 expression is elevated in severe preeclamptic placentas and suppresses trophoblast cell invasion via β1-integrin signaling. , 2011, The Journal of clinical endocrinology and metabolism.

[31]  T. Konno,et al.  Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions , 2011, Proceedings of the National Academy of Sciences.

[32]  Z. Prohászka,et al.  Complement activation in animal and human pregnancies as a model for immunological recognition. , 2011, Molecular immunology.

[33]  M. Dramé,et al.  Prediction of the fetal status in noninvasive management of alloimmune thrombocytopenia. , 2011, Blood.

[34]  Jacqui Detmar,et al.  Vessel tortuousity and reduced vascularization in the fetoplacental arterial tree after maternal exposure to polycyclic aromatic hydrocarbons. , 2011, American journal of physiology. Heart and circulatory physiology.

[35]  J. Freedman,et al.  Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy. , 2010, Blood.

[36]  H. Mizunuma,et al.  Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia. , 2010, Journal of reproductive immunology.

[37]  A. Bocking,et al.  The Prevalence of Chronic Deciduitis in Cases of Preterm Labor without Clinical Chorioamnionitis , 2009, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[38]  M. Sakai,et al.  Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion. , 2008, The American journal of pathology.

[39]  Toshiaki Watanabe,et al.  Transplacental transport and tissue distribution of biotin in mice at midgestation , 2008, Congenital anomalies.

[40]  J. Hanna,et al.  Decidual NK cells regulate key developmental processes at the human fetal-maternal interface , 2006, Nature Medicine.

[41]  T. Libermann,et al.  Soluble endoglin contributes to the pathogenesis of preeclampsia , 2006, Nature Medicine.

[42]  R. Hynes,et al.  A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. , 2006, Blood.

[43]  S. Ayis,et al.  Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion , 2006, The Journal of pathology.

[44]  N. Perico,et al.  Mechanisms of Disease: pre-eclampsia , 2005, Nature Clinical Practice Nephrology.

[45]  X. Chen,et al.  Human decidual NK cells form immature activating synapses and are not cytotoxic , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Surendra Sharma,et al.  Uterine NK Cells Mediate Inflammation-Induced Fetal Demise in IL-10-Null Mice , 2005, The Journal of Immunology.

[47]  M. Colonna,et al.  Pathways Participating in Activation of Mouse Uterine Natural Killer Cells During Pregnancy1 , 2005, Biology of reproduction.

[48]  F. Askin,et al.  Chronic villitis in untreated neonatal alloimmune thrombocytopenia: an etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy. , 2005, American journal of obstetrics and gynecology.

[49]  R. Kishi,et al.  Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype. , 2005, Molecular human reproduction.

[50]  C. Clarke,et al.  Trafficking of Circulating Pro-NK Cells to the Decidualizing Uterus: Regulatory Mechanisms in the Mouse and Human , 2005, Immunological investigations.

[51]  Jun Wang,et al.  α5β1, αVβ3 and the platelet-associated integrin αIIbβ3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells , 2004 .

[52]  Yukio Nakamura,et al.  αvβ3 Integrin Signaling Pathway Is Involved in Insulin-Like Growth Factor I-Stimulated Human Extravillous Trophoblast Cell Migration , 2003 .

[53]  E. Steegers,et al.  Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies. , 2002, Human reproduction.

[54]  T. Rau,et al.  Neonatal Alloimmune Thrombocytopenia with HLA Alloimmunization: Case Report with Immunohematologic and Placental Findings , 2002, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[55]  J. Rossant,et al.  Placental development: Lessons from mouse mutants , 2001, Nature Reviews Genetics.

[56]  James J. Walker,et al.  Pre-eclampsia , 2000, The Lancet.

[57]  V. Ganapathy,et al.  Placental transporters relevant to drug distribution across the maternal-fetal interface. , 2000, The Journal of pharmacology and experimental therapeutics.

[58]  B. Croy,et al.  Engraftment of Bone Marrow from Severe Combined Immunodeficient (SCID) Mice Reverses the Reproductive Deficits in Natural Killer Cell–deficient tgε26 Mice , 1998, The Journal of experimental medicine.

[59]  G. Pár,et al.  Progesterone and Non‐specific Immunologic Mechanisms in Pregnancy , 1997, American journal of reproductive immunology.

[60]  R. Berkowitz,et al.  Fetal alloimmune thrombocytopenia. , 1997, The New England journal of medicine.

[61]  J. S. Hunt,et al.  Uterine natural killer cells: insights into lineage relationships and functions from studies of pregnancies in mutant and transgenic mice. , 1996, Natural immunity.

[62]  E. Haddad,et al.  Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells , 1995, The Journal of experimental medicine.

[63]  G. Mueller‐Eckhardt,et al.  348 CASES OF SUSPECTED NEONATAL ALLOIMMUNE THROMBOCYTOPENIA , 1989, The Lancet.

[64]  R. Berkowitz,et al.  Antenatal treatment of neonatal alloimmune thrombocytopenia. , 1988, The New England journal of medicine.

[65]  A. D. de Fougerolles,et al.  Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate. , 1987, Journal of reproductive immunology.

[66]  J. Hall,et al.  The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes. , 1984, Journal of immunology.

[67]  J. Bussel,et al.  Review of fetal and neonatal immune cytopenias. , 2015, Clinical advances in hematology & oncology : H&O.

[68]  J. Bulmer,et al.  The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders. , 2015, Advances in experimental medicine and biology.

[69]  B. Huppertz,et al.  Distribution of decidual natural killer cells and macrophages in the neighbourhood of the trophoblast invasion front: a quantitative evaluation. , 2014, Human reproduction.

[70]  A. Doubell.  Partners in Pregnancy , 2014 .

[71]  J. Zeman,et al.  quantitative evaluation of by , 2010 .

[72]  C. Tayade,et al.  Analysis of uterine natural killer cells in mice. , 2010, Methods in molecular biology.

[73]  Jun Wang,et al.  Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. , 2004, Developmental biology.

[74]  P. Parham.  NK Cells and Trophoblasts: Partners in Pregnancy , 2004 .

[75]  Yukio Nakamura,et al.  Alphavbeta3 integrin signaling pathway is involved in insulin-like growth factor I-stimulated human extravillous trophoblast cell migration. , 2003, Endocrinology.