Water Vapor Transport and Its Effects on the Deposition of Hygroscopic Droplets in a Human Upper Airway Model

The fundamentals of 3-D airflow as well as heat and water vapor transport and droplet vaporization (or hygroscopicity) are described for a human upper airway model under steady laminar-transitional-turbulent inspiratory flow conditions. Water vapor distributions from the mouth to the first four generations of the tracheobronchial tree are given in terms of relative humidity or mass fraction. The mass transfer coefficients of water vapor are correlated as a function of local flow rate and temperature-dependent diffusivity, which can be readily used for estimating the regional water loss or moisture variations in the human upper airways. Furthermore, the dynamics of hygroscopicity and deposition of isotonic saline droplets have been simulated as an example, applying the basic theory. Specifically, droplet evaporation rates and deposition pattern are analyzed and the effects of inhalation flow rates and thermodynamic air properties are discussed.

[1]  Clement Kleinstreuer,et al.  Aerosol Deposition Efficiencies and Upstream Release Positions for Different Inhalation Modes in an Upper Bronchial Airway Model , 2002 .

[2]  A. Berlemont.  Heat and mass transfer coupling between vaporizing droplets and turbulence using a Lagrangian approach , 1996 .

[3]  K. Nishino,et al.  Statistical simulation of particle deposition on the wall from turbulent dispersed pipe flow , 2000 .

[4]  Clement Kleinstreuer,et al.  Species heat and mass transfer in a human upper airway model , 2003 .

[5]  H. C. Simpson.  Bubbles, drops and particles , 1980 .

[6]  Clement Kleinstreuer,et al.  Transient airflow structures and particle transport in a sequentially branching lung airway model , 2002 .

[7]  W. Finlay,et al.  Improved numerical simulation of aerosol deposition in an idealized mouth-throat , 2004 .

[8]  Clement Kleinstreuer,et al.  Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model , 2002 .

[9]  D. J. Horton,et al.  Heat and water loss from the airways and exercise-induced asthma. , 1977, Respiration; international review of thoracic diseases.

[10]  M. Kulmala,et al.  ``Evaporation of ventilated water droplet: connection between heat and mass transfer'' [J. Aerosol Sci. 32 (2001) 739-748] , 2002 .

[11]  Y. Cheng,et al.  Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. , 1997, Journal of biomechanical engineering.

[12]  Thomas Heistracher,et al.  Local particle deposition patterns may play a key role in the development of lung cancer. , 2003, Journal of applied physiology.

[13]  C. E. Johnson,et al.  An analysis of sensible respiratory heat exchange during inspiration under environmental conditions of deep diving. , 1977, Journal of biomechanical engineering.

[14]  C. Kleinstreuer,et al.  Isotonic and hypertonic saline droplet deposition in a human upper airway model. , 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[15]  S. Yariv,et al.  Physical Chemistry of Surfaces , 1979 .

[16]  T. Vesala,et al.  Models for condensational growth and evaporation of binary aerosol particles , 1997 .

[17]  Clement Kleinstreuer,et al.  Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition , 2001, Journal of Fluid Mechanics.

[18]  Clement Kleinstreuer,et al.  Low-Reynolds-Number Turbulent Flows in Locally Constricted Conduits: A Comparison Study , 2003 .

[19]  A. Eisner,et al.  Coupled mass and energy transport phenomena in aerosol/vapor-laden gases-I. theory of the hygroscopic aerosol effects on temperature and relative humidity patterns of inspired air , 1990 .

[20]  W. Kreyling,et al.  Inhalation of salt aerosol particles—II. growth and deposition in the human respiratory tract☆ , 1988 .

[21]  W. Finlay,et al.  The effect on regional lung deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase , 1995 .

[22]  V. Truong,et al.  Electrolyte thickness dependence of the electrochromic behavior of ‘‘a‐WO3’’ films , 1985 .

[23]  P. Scherer,et al.  A theoretical model of localized heat and water vapor transport in the human respiratory tract. , 1986, Journal of biomechanical engineering.

[24]  A. Gosman,et al.  Aspects of Computer Simulation of Liquid-Fueled Combustors , 1983 .

[25]  Clement Kleinstreuer,et al.  Comparison of micro- and nano-size particle depositions in a human upper airway model , 2005 .

[26]  C Kleinstreuer,et al.  Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model. , 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[27]  N. B. Vargaftik.  Tables on the thermophysical properties of liquids and gases: In normal and dissociated states , 1975 .

[28]  David M. Broday,et al.  Growth and Deposition of Hygroscopic Particulate Matter in the Human Lungs , 2001 .

[29]  T. Martonen,et al.  Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic Additives , 2004, Pharmaceutical Research.

[30]  D. Wilcox.  Turbulence modeling for CFD , 1993 .

[31]  A. Benaissa,et al.  Modelling evaporation of multicomponent fuel droplets under ambient temperature conditions , 2002 .

[32]  C. Kleinstreuer,et al.  Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols , 2004 .

[33]  Chak K. Chan,et al.  Study of the Hygroscopic Properties of Selected Pharmaceutical Aerosols Using Single Particle Levitation , 2000, Pharmaceutical Research.

[34]  A. Gosman,et al.  Aspects of computer simulation of liquid-fuelled combustors , 1981 .

[35]  M. Nuckols.  Heat and Water Vapor Transfer in the Human Respiratory System at Hyperbaric Conditions. , 1981 .

[36]  P. Worth Longest,et al.  Efficient computation of micro-particle dynamics including wall effects , 2004 .

[37]  C. Kleinstreuer,et al.  Airflow structures and nano-particle deposition in a human upper airway model , 2004 .

[38]  Clement Kleinstreuer,et al.  Laminar-to-turbulent fluid-particle flows in a human airway model , 2003 .

[39]  C. Carrington,et al.  Morphometry of the Human Lung , 1965, The Yale Journal of Biology and Medicine.

[40]  W. Finlay,et al.  Regional deposition of inhaled hygroscopic aerosols: in vivo SPECT compared with mathematical modeling. , 1996, Journal of applied physiology.

[41]  I Gonda,et al.  Mathematical modeling of heat and water transport in human respiratory tract. , 1990, Journal of applied physiology.

[42]  P. James,et al.  On the effect of anisotropy on the turbulent dispersion and deposition of small particles , 1999 .

[43]  Günter Oberdörster,et al.  Estimation of the Deposition of Aerosolized Drugs in the Human Respiratory Tract Due to Hygroscopic Growth , 1989 .

[44]  G. Faeth,et al.  Evaluation of a stochastic model of particle dispersion in a turbulent round jet , 1983 .

[45]  Markku Kulmala,et al.  Evaporation of ventilated water droplet: connection between heat and mass transfer , 2001 .

[46]  F. Bracco,et al.  Stochastic particle dispersion modeling and the tracer‐particle limit , 1992 .

[47]  R. Rowell,et al.  Physical Chemistry of Surfaces, 6th ed. , 1998 .

[48]  Thomas Heistracher,et al.  Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations , 1999 .

[49]  W. Kreyling,et al.  A method for the approximation of the relative humidity in the upper human airways. , 1985, Bulletin of mathematical biology.

[50]  Warren H. Finlay,et al.  The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction , 2001 .

[51]  Peter J. Hunter,et al.  Modeling Water Vapor and Heat Transfer in the Normal and the Intubated Airways , 2004, Annals of Biomedical Engineering.

[52]  P. Moin,et al.  Turbulence statistics in fully developed channel flow at low Reynolds number , 1987, Journal of Fluid Mechanics.

[53]  H. F. Bowman,et al.  Thermal mapping of the airways in humans. , 1985, Journal of applied physiology.

[54]  D. Shepard.  A two-dimensional interpolation function for irregularly-spaced data , 1968, ACM National Conference.

[55]  D. Galler,et al.  Relationship between the humidity and temperature of inspired gas and the function of the airway mucosa. , 1996, Critical care medicine.

[56]  R. C. Schroter,et al.  Transport Phenomena in the Human Nasal Cavity: A Computational Model , 1998, Annals of Biomedical Engineering.

[57]  E G Cravalho,et al.  Finite difference analysis of respiratory heat transfer. , 1986, Journal of applied physiology.

[58]  P. Morrow.  Factors determining hygroscopic aerosol deposition in airways. , 1986, Physiological reviews.

[59]  C Kleinstreuer,et al.  Aerosol transport and deposition in sequentially bifurcating airways. , 2000, Journal of biomechanical engineering.

[60]  F. Cinkotai.  The behaviour of sodium chloride particles in moist air , 1971 .