Symposium : New Technologies for Nutrition Research New Technologies for Nutrition Research 1

The Experimental Biology 2003 symposium entitled “New Technologies for Nutrition Research” was organized to highlight new and emerging technologies, including nanotechnology and proteomics, and to suggest ways for their integration into nutrition research. Speakers focused on topics that included accelerator mass spectrometry for ultra-low level radiolabel tracing, nanodevices for real-time optical intracellular sensing, mass spectrometric techniques for examining protein expression, as well as potential applications for nanotechnology in the food sciences. These technologies may be particularly useful in obtaining accurate spatial information and low-level detection of essential and nonessential bioactive food components (nutrients) and their metabolites, and in enhancing the understanding of the impact of nutrient/metabolite and biomolecular interactions. Highlights from this symposium are presented briefly herein. J. Nutr. 134: 681–685, 2004.

[1]  P. Schneider,et al.  Quantitation of in vivo human folate metabolism. , 2004, The American journal of clinical nutrition.

[2]  M. Ferrari,et al.  Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group. , 2003, Circulation.

[3]  Paul Takhistov,et al.  Nanotechnology: A New Frontier in Food Science , 2003 .

[4]  Richard Weindruch,et al.  A design and statistical perspective on microarray gene expression studies in nutrition: the need for playful creativity and scientific hard-mindedness. , 2003, Nutrition.

[5]  A. Bhagwat.  Simultaneous detection of Escherichia coli O157:H7, Listeria monocytogenes and Salmonella strains by real-time PCR. , 2003, International journal of food microbiology.

[6]  A. Clifford,et al.  Effect of Dietary Constituents With Chemopreventive Potential on Adduct Formation of a Low Dose of the Heterocyclic Amines PhIP and IQ and Phase II Hepatic Enzymes , 2003, Nutrition and cancer.

[7]  Tim Hui-Ming Huang,et al.  Methylation target array for rapid analysis of CpG island hypermethylation in multiple tissue genomes. , 2003, The American journal of pathology.

[8]  Christopher G Thanos,et al.  Nanotechnology and medicine , 2003, Expert opinion on biological therapy.

[9]  Tim Hui-Ming Huang,et al.  Triple analysis of the cancer epigenome: an integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation. , 2003, Cancer research.

[10]  S. Kersten,et al.  Nutrigenomics: goals and strategies , 2003, Nature Reviews Genetics.

[11]  Thommey P. Thomas,et al.  Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor , 2002, Pharmaceutical Research.

[12]  Sudhir Srivastava,et al.  Nanotechnology in Early Detection of Cancer , 2002, Laboratory Investigation.

[13]  Frank Larimer,et al.  Integrating 'top-down" and "bottom-up" mass spectrometric approaches for proteomic analysis of Shewanella oneidensis. , 2002, Journal of proteome research.

[14]  S. C. Lee.  Dendrimers in Nanobiological Devices , 2002 .

[15]  Masanori Sugisaka,et al.  From molecular biology to nanotechnology and nanomedicine. , 2002, Bio Systems.

[16]  Erkki Ruoslahti,et al.  Targeting the prostate for destruction through a vascular address , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[17]  K. Hamad-Schifferli,et al.  Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna , 2002, Nature.

[18]  P. Meers,et al.  Enzyme-activated targeting of liposomes. , 2001, Advanced drug delivery reviews.

[19]  Tom Misteli,et al.  Kinetic modelling approaches to in vivo imaging , 2001, Nature Reviews Molecular Cell Biology.

[20]  J. Aylott,et al.  A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma. , 2001, Analytical chemistry.

[21]  H. Maeda,et al.  Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[22]  R. Duncan,et al.  Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[23]  D S Goldin,et al.  The NASA-NCI Collaboration on Biomolecular Sensors , 2001, Science.

[24]  James R. Baker,et al.  The Synthesis and Testing of Anti-Cancer Therapeutic Nanodevices , 2001 .

[25]  B G De Grooth,et al.  Biomolecular interactions measured by atomic force microscopy. , 2000, Biophysical journal.

[26]  P. Schneider,et al.  Long-term kinetic study of beta-carotene, using accelerator mass spectrometry in an adult volunteer. , 2000, Journal of lipid research.

[27]  J. Taylor,et al.  Nucleic acid-triggered catalytic drug release. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[28]  H. Clark,et al.  Optical nanosensors for chemical analysis inside single living cells. 1. Fabrication, characterization, and methods for intracellular delivery of PEBBLE sensors. , 1999, Analytical chemistry.

[29]  H. Clark,et al.  Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. , 1999, Analytical chemistry.

[30]  G. Georgiou,et al.  Molecular determinants of bacterial adhesion monitored by atomic force microscopy. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Susan L. R. Barker,et al.  Subcellular optochemical nanobiosensors: probes encapsulated by biologically localised embedding (PEBBLEs) , 1998 .

[32]  Stephen C. Lee,et al.  Biotechnology for nanotechnology , 1998 .

[33]  R. Phair,et al.  Development of kinetic models in the nonlinear world of molecular cell biology. , 1997, Metabolism: clinical and experimental.

[34]  D. Brant,et al.  Imaging of individual biopolymers and supramolecular assemblies using noncontact atomic force microscopy. , 1997, Biopolymers.

[35]  Ronald C. Beavis,et al.  Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. , 1991, Analytical chemistry.

[36]  M. Mann,et al.  Electrospray Ionization for Mass Spectrometry of Large Biomolecules , 1990 .

[37]  A. Clifford,et al.  Dual isotope test for assessing beta-carotene cleavage to vitamin A in humans. , 2002, European journal of nutrition.

[38]  L. Jelinski.  Biologically Related Aspects of Nanoparticles, Nanostructured Materials, and Nanodevices , 1999 .

[39]  P. Schneider,et al.  The dynamics of folic acid metabolism in an adult given a small tracer dose of 14C-folic acid. , 1998, Advances in experimental medicine and biology.

[40]  R. Duncan.  POLYMER THERAPEUTICS FOR TUMOUR SPECIFIC DELIVERY , 1997 .

[41]  K. Turteltaub,et al.  Accelerator mass spectrometry : isotope quantification at attomole sensitivity , 1995 .