CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns

[1]  O. Levy,et al.  Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g , 2021, ImmunoHorizons.

[2]  J. Mascola,et al.  A proof of concept for structure-based vaccine design targeting RSV in humans , 2019, Science.

[3]  B. Graham,et al.  A unique combination adjuvant modulates immune responses preventing vaccine-enhanced pulmonary histopathology after a single dose vaccination with fusion protein and challenge with respiratory syncytial virus. , 2019, Virology.

[4]  D. Verhoeven.  Influence of Immunological Maturity on Respiratory Syncytial Virus-Induced Morbidity in Young Children. , 2019, Viral immunology.

[5]  S. Varga,et al.  Identification of Novel Respiratory Syncytial Virus CD4+ and CD8+ T Cell Epitopes in C57BL/6 Mice , 2019, ImmunoHorizons.

[6]  Martin Eisenacher,et al.  The PRIDE database and related tools and resources in 2019: improving support for quantification data , 2018, Nucleic Acids Res..

[7]  B. Weinberger,et al.  Adjuvant strategies to improve vaccination of the elderly population , 2018, Current opinion in pharmacology.

[8]  Sven Burgdorf,et al.  Current Concepts of Antigen Cross-Presentation , 2018, Front. Immunol..

[9]  J. Greenbaum,et al.  Improved methods for predicting peptide binding affinity to MHC class II molecules , 2018, Immunology.

[10]  R. Coler,et al.  Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan , 2018, Front. Immunol..

[11]  A. Sivasubramanian,et al.  Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation , 2018, Immunity.

[12]  Amélie Collins,et al.  Why are preterm newborns at increased risk of infection? , 2018, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[13]  Thawfeek M. Varusai,et al.  The Reactome Pathway Knowledgebase , 2017, Nucleic acids research.

[14]  J. Wynn,et al.  Editorial: The Neonatal Immune System: A Unique Host-Microbial Interface , 2017, Front. Pediatr..

[15]  O. Levy,et al.  Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization , 2017, Front. Immunol..

[16]  M. Lucero,et al.  Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study , 2017, The Lancet.

[17]  P. van Endert,et al.  MHC Class I Cross-Presentation: Stage Lights on Sec22b. , 2017, Trends in immunology.

[18]  O. Levy,et al.  TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. , 2017, JCI insight.

[19]  J. Schwarze,et al.  The Human Immune Response to Respiratory Syncytial Virus Infection , 2017, Clinical Microbiology Reviews.

[20]  Minoru Kanehisa,et al.  KEGG: new perspectives on genomes, pathways, diseases and drugs , 2016, Nucleic Acids Res..

[21]  Damian Szklarczyk,et al.  The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible , 2016, Nucleic Acids Res..

[22]  S. Reed,et al.  Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[23]  S. Reed,et al.  Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization , 2016, The Journal of Immunology.

[24]  R. Karron,et al.  Challenges and opportunities in RSV vaccine development: Meeting report from FDA/NIH workshop. , 2016, Vaccine.

[25]  Andrew D. Rouillard,et al.  The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins , 2016, Database J. Biol. Databases Curation.

[26]  S. Reed,et al.  In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. , 2016, Cytokine.

[27]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[28]  R. Coler,et al.  The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age , 2016, Biogerontology.

[29]  F. Polack,et al.  TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization. , 2015, The Journal of clinical investigation.

[30]  Jamie Perin,et al.  Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis , 2015, The Lancet.

[31]  Heiner Koch,et al.  Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns , 2014, Molecular & Cellular Proteomics.

[32]  P. Openshaw,et al.  Immunity to RSV in Early-Life , 2014, Front. Immunol..

[33]  V. Band,et al.  A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells* , 2014, The Journal of Biological Chemistry.

[34]  B. Chiang,et al.  The difference in immune response and IL-12p35 methylation between newborns and adults , 2014, Journal of Biomedical Science.

[35]  R. Tampé,et al.  TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation , 2014, Cell.

[36]  P. Andersen,et al.  Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant. , 2014, Vaccine.

[37]  Marco Y. Hein,et al.  Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.

[38]  Mark M. Davis,et al.  Deconstructing the Peptide-MHC Specificity of T Cell Recognition , 2014, Cell.

[39]  Li-Xin Wei,et al.  Inhibition of tumor necrosis factor alpha reduces the outgrowth of hepatic micrometastasis of colorectal tumors in a mouse model of liver ischemia-reperfusion injury , 2014, Journal of Biomedical Science.

[40]  S. Reed,et al.  Key roles of adjuvants in modern vaccines , 2013, Nature Medicine.

[41]  Cinque S. Soto,et al.  Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus , 2013, Science.

[42]  J. Bryce,et al.  Millennium Development Goals 4 and 5: progress and challenges , 2013, BMC Medicine.

[43]  Christine M. Hoeman,et al.  Developmental Expression of IL-12Rβ2 on Murine Naive Neonatal T Cells Counters the Upregulation of IL-13Rα1 on Primary Th1 Cells and Balances Immunity in the Newborn , 2013, The Journal of Immunology.

[44]  U. Baxa,et al.  Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody , 2013, Science.

[45]  O. Levy,et al.  Plasma‐mediated immune suppression: a neonatal perspective , 2013, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[46]  Bernadette A. Thomas,et al.  Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[47]  Karin Breuer,et al.  InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation , 2012, Nucleic Acids Res..

[48]  Ruth R. Montgomery,et al.  Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. , 2012, Immunity.

[49]  Ofer Levy,et al.  Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. , 2012, The Journal of allergy and clinical immunology.

[50]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[51]  P. Bruhns.  Properties of mouse and human IgG receptors and their contribution to disease models. , 2012, Blood.

[52]  O. Levy,et al.  Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors , 2012, PloS one.

[53]  D. Hodgins,et al.  Vaccination of neonates: problem and issues. , 2012, Vaccine.

[54]  C. Palomo,et al.  Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention , 2012, Proceedings of the National Academy of Sciences.

[55]  S. Ygberg,et al.  The developing immune system – from foetus to toddler , 2012, Acta paediatrica.

[56]  J. Enninga,et al.  Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells , 2011, Cell.

[57]  Satoko Yamamoto,et al.  INOH: ontology-based highly structured database of signal transduction pathways , 2011, Database J. Biol. Databases Curation.

[58]  J. Schmidt,et al.  Vaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine induction. , 2011, Vaccine.

[59]  H. Whittle,et al.  Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants , 2011, PloS one.

[60]  K. Herkner,et al.  MicroRNA-146: Tiny Player in Neonatal Innate Immunity? , 2010, Neonatology.

[61]  P. Kwong,et al.  Structural basis of respiratory syncytial virus neutralization by motavizumab , 2010, Nature Structural &Molecular Biology.

[62]  Gary D Bader,et al.  NetPath: a public resource of curated signal transduction pathways , 2010, Genome Biology.

[63]  J. Rossen,et al.  A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants , 2009, Journal of Virology.

[64]  Christine M. Hoeman,et al.  Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells. , 2009, Trends in immunology.

[65]  O. Baker,et al.  PKC{alpha}{beta}{gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells. , 2009, American journal of physiology. Cell physiology.

[66]  P. Andersen,et al.  A Liposome-Based Mycobacterial Vaccine Induces Potent Adult and Neonatal Multifunctional T Cells through the Exquisite Targeting of Dendritic Cells , 2009, PloS one.

[67]  P. Bruhns,et al.  Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. , 2009, Blood.

[68]  M. Suter,et al.  Phenotype and function of neonatal DC , 2009, European journal of immunology.

[69]  O. Levy,et al.  Safety and efficacy of neonatal vaccination , 2009, European journal of immunology.

[70]  Kenneth H. Buetow,et al.  PID: the Pathway Interaction Database , 2008, Nucleic Acids Res..

[71]  W. Mitzner,et al.  Lack of antibody affinity maturation due to poor Toll stimulation led to enhanced RSV disease , 2008, Nature medicine.

[72]  P. Andersen,et al.  Adult-Like Anti-Mycobacterial T Cell and In Vivo Dendritic Cell Responses Following Neonatal Immunization with Ag85B-ESAT-6 in the IC31® Adjuvant , 2008, PloS one.

[73]  F. Fazal,et al.  Activation of Syk by Protein Kinase C-δ Regulates Thrombin-induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Tyrosine Phosphorylation of RelA/p65* , 2008, Journal of Biological Chemistry.

[74]  B. Graham,et al.  Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection. , 2007, Virology.

[75]  Jennifer L. Reed,et al.  Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses , 2007, The Journal of infectious diseases.

[76]  Mi Hee Lee,et al.  Eosinophil Cationic Protein and Chemokines in Nasopharyngeal Secretions of Infants with Respiratory Syncytial Virus (RSV) Bronchiolitis and Non-RSV Bronchiolitis , 2007, Journal of Korean medical science.

[77]  B. Graham,et al.  The histopathology of fatal untreated human respiratory syncytial virus infection , 2007, Modern Pathology.

[78]  O. Levy,et al.  Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. , 2006, Blood.

[79]  O. Levy,et al.  The Adenosine System Selectively Inhibits TLR-Mediated TNF-α Production in the Human Newborn1 , 2006, The Journal of Immunology.

[80]  L. Kalish,et al.  Innate Immunity of the Human Newborn Is Polarized Toward a High Ratio of IL-6/TNF-α Production In Vitro and In Vivo , 2006, Pediatric Research.

[81]  O. Levy,et al.  The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. , 2006, Journal of immunology.

[82]  G. Rhodes,et al.  DNA immunization against respiratory syncytial virus (RSV) in infant rhesus monkeys. , 2005, Vaccine.

[83]  S. Peng,et al.  T-bet regulates T-independent IgG2a class switching. , 2003, International immunology.

[84]  T. Kuiken,et al.  Immunization of Macaques with Formalin-Inactivated Respiratory Syncytial Virus (RSV) Induces Interleukin-13-Associated Hypersensitivity to Subsequent RSV Infection , 2002, Journal of Virology.

[85]  A. Verma,et al.  Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. , 2002, The Journal of biological chemistry.

[86]  H. Rammensee,et al.  SYFPEITHI: database for MHC ligands and peptide motifs , 1999, Immunogenetics.

[87]  D. Zurakowski,et al.  A statistically defined endpoint titer determination method for immunoassays. , 1998, Journal of immunological methods.

[88]  M. Hagen,et al.  Atypical Pulmonary Eosinophilia Is Mediated by a Specific Amino Acid Sequence of the Attachment (G) Protein of Respiratory Syncytial Virus , 1998, The Journal of experimental medicine.

[89]  L. Anderson,et al.  Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern , 1996, Journal of virology.

[90]  B. Graham,et al.  Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. , 1993, Journal of immunology.

[91]  R. Coffman,et al.  Lymphokine control of in vivo immunoglobulin isotype selection. , 1990, Annual review of immunology.

[92]  R. Chanock,et al.  Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. , 1969, American journal of epidemiology.