Lymphatic response to depilation‐induced inflammation in mouse ear assessed with label‐free optical lymphangiography

Optical microangiography (OMAG) is a noninvasive technique capable of imaging 3D microvasculature. OMAG‐based optical lymphangiography has been developed for 3D visualization of lymphatic vessels without the need for exogenous contrast agents. In this study, we utilize the optical lymphangiography to investigate dynamic changes in lymphatic response within skin tissue to depilation‐induced inflammation by using mouse ear as a simple tissue model.

[1]  L. Munn,et al.  Imaging the lymphatic system. , 2014, Microvascular research.

[2]  Ruikang K. Wang,et al.  Theory, developments and applications of optical coherence tomography , 2005 .

[3]  J. Machac,et al.  Reverse echelon node and a lymphatic ectasia in the same patient during breast lymphoscintigraphy: the importance of injection and imaging technique. , 2004, The British journal of radiology.

[4]  Ruikang K. Wang,et al.  Quantifying Optical Microangiography Images Obtained from a Spectral Domain Optical Coherence Tomography System , 2012, Int. J. Biomed. Imaging.

[5]  Tatiana V. Petrova,et al.  Lymphangiogenesis in development and human disease , 2005, Nature.

[6]  T. Stijnen,et al.  Meta-analysis of positron emission tomographic and computed tomographic imaging in detecting mediastinal lymph node metastases in nonsmall cell lung cancer. , 2005, The Annals of thoracic surgery.

[7]  C Ross Ethier,et al.  Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head. , 2011, Investigative ophthalmology & visual science.

[8]  Ruikang K. Wang,et al.  Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. , 2010, Optics letters.

[9]  John C Rasmussen,et al.  New Horizons for Imaging Lymphatic Function , 2008, Annals of the New York Academy of Sciences.

[10]  G. Yancopoulos,et al.  Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. , 2008, Developmental biology.

[11]  Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo. , 2012, Optics letters.

[12]  R. Weissleder,et al.  A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation. , 2005, Urology.

[13]  Po-Whei Huang,et al.  Automatic Classification for Pathological Prostate Images Based on Fractal Analysis , 2009, IEEE Transactions on Medical Imaging.

[14]  Yulei Jiang,et al.  Accuracy of axillary lymph node staging in breast cancer patients: an observer-performance study comparison of MRI and ultrasound. , 2013, Academic radiology.

[15]  A. Luciani,et al.  Imaging the lymphatic system: possibilities and clinical applications , 2004, European Radiology.

[16]  P. W. Vestal Preoperative preparation of the skin with a depilatory cream and a detergent. , 1952, American journal of surgery.

[17]  Lloyd H. Michael,et al.  The Guide for the Care and Use of Laboratory Animals. , 2016, ILAR journal.

[18]  Ruikang K. Wang,et al.  Label-free optical lymphangiography: development of an automatic segmentation method applied to optical coherence tomography to visualize lymphatic vessels using Hessian filters , 2013, Journal of biomedical optics.

[19]  David A. Tuveson,et al.  Maximizing mouse cancer models , 2007, Nature Reviews Cancer.

[20]  Benjamin J Vakoc,et al.  Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging , 2009, Nature Medicine.

[21]  T. Petrova,et al.  Lymphatic vascular morphogenesis in development, physiology, and disease , 2011, The Journal of cell biology.

[22]  J. B. Kinmonth,et al.  Lymphangiography in man; a method of outlining lymphatic trunks at operation. , 1952, Clinical science.

[23]  R. Weissleder,et al.  The lymphatic system: diagnostic imaging studies. , 1989, Radiology.

[24]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[25]  S. Baba,et al.  Prediction of true-negative lymph node metastasis in clinical IA non-small cell lung cancer by measuring standardized uptake values on positron emission tomography , 2012, Surgery Today.

[26]  R. Black,et al.  Modelling the lymphatic system: challenges and opportunities , 2012, Journal of The Royal Society Interface.

[27]  Takehiko Fujisawa,et al.  Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer. , 2006, Chest.

[28]  Ruikang K. Wang,et al.  Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography , 2011, Biomedical optics express.

[29]  S. Stacker,et al.  Lymphangiogenesis and lymphatic vessel remodelling in cancer , 2014, Nature Reviews Cancer.

[30]  Ruikang K. Wang,et al.  Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds. , 2010, Optics express.

[31]  Sunkuk Kwon,et al.  Emerging lymphatic imaging technologies for mouse and man. , 2014, The Journal of clinical investigation.

[32]  Ruikang K. Wang,et al.  High resolution imaging of acne lesion development and scarring in human facial skin using OCT‐based microangiography , 2015, Lasers in surgery and medicine.

[33]  I-Chih Tan,et al.  Lymphatic imaging in humans with near-infrared fluorescence. , 2009, Current opinion in biotechnology.

[34]  I. Koshima,et al.  Low-invasive lymphatic surgery and lymphatic imaging for completely healed intractable pudendal lymphorrhea after gynecologic cancer treatment. , 2012, Journal of minimally invasive gynecology.

[35]  Vyacheslav Kalchenko,et al.  Label free in vivo laser speckle imaging of blood and lymph vessels. , 2012, Journal of biomedical optics.

[36]  D. Sloan,et al.  Lymphoscintigraphy of melanoma: Lymphatic channel activity guides localization of sentinel lymph nodes, and gamma camera imaging/counting confirms presence of radiotracer in excised nodes , 2001, Annals of nuclear medicine.

[37]  Chulhong Kim,et al.  Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats--volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging. , 2010, Radiology.

[38]  Guillermo Oliver,et al.  Lymphatic Vasculature Development , 2008, Annals of the New York Academy of Sciences.

[39]  Seok-ki Kim,et al.  Comparison of the accuracy of magnetic resonance imaging and positron emission tomography/computed tomography in the presurgical detection of lymph node metastases in patients with uterine cervical carcinoma , 2006, Cancer.

[40]  S. Zhou,et al.  Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans , 2012, Biomedical optics express.