Vascular function, physical performance and aging

[1]  J. Levick,et al.  An Introduction to Cardiovascular Physiology , 2009 .

[2]  V. Convertino,et al.  Effect of 6 months of exercise training on cardiovascular responses to head-up tilt in the elderly. , 2008, Clinical physiology.

[3]  Z. Mourelatos Introduction and Historical Background , 2008 .

[4]  M. Welsch,et al.  Regional changes in reactive hyperemic blood flow during exercise training: time-course adaptations , 2007, Dynamic medicine : DM.

[5]  R. Hainsworth,et al.  Counterpoint: active venoconstriction is not important in maintaining or raising end-diastolic volume and stroke volume during exercise and orthostasis. , 2006, Journal of applied physiology.

[6]  Jason D. Allen,et al.  Biphasic responses of the brachial artery diameter following forearm occlusion: a blunted response in the elderly , 2006, Dynamic medicine : DM.

[7]  D. Wray,et al.  Evidence of preserved endothelial function and vascular plasticity with age. , 2006, American journal of physiology. Heart and circulatory physiology.

[8]  D. Proctor,et al.  Blood flow to exercising limbs varies with age, gender, and training status. , 2005, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[9]  K. Pyke,et al.  The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function , 2005, The Journal of physiology.

[10]  Hirofumi Tanaka,et al.  Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses. , 2005, Medicine and science in sports and exercise.

[11]  D. Celermajer Brachial artery FMD with 5-minute distal cuff occlusion--a useful pathophysiological test after all! , 2005, Journal of applied physiology.

[12]  W. Franke,et al.  Effects of a 6-mo endurance-training program on venous compliance and maximal lower body negative pressure in older men and women. , 2005, Journal of applied physiology.

[13]  Edward G Lakatta,et al.  Arterial aging: is it an immutable cardiovascular risk factor? , 2005, Hypertension.

[14]  Christopher H. Morrell,et al.  Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults , 2005, Circulation.

[15]  P. Ades,et al.  Accelerated Decline of Aerobic Fitness With Healthy Aging: What Is the Good News? , 2005, Circulation.

[16]  M. Joyner,et al.  Impaired modulation of sympathetic α‐adrenergic vasoconstriction in contracting forearm muscle of ageing men , 2005, The Journal of physiology.

[17]  P C de Groot,et al.  Endothelial function of young healthy males following whole body resistance training. , 2005, Journal of applied physiology.

[18]  R. E. Gardner,et al.  Physical Function and Quality of Life in Older Adults: Sex Differences , 2005, Southern medical journal.

[19]  N. Skolnik,et al.  Diabetes Care 2005 , 2005 .

[20]  M. E. Cress,et al.  Continuous-scale physical functional performance test: validity, reliability, and sensitivity of data for the short version. , 2005, Physical therapy.

[21]  G. Tumminello,et al.  Exercise hyperventilation, dyspnea sensation, and ergoreflex activation in lone atrial fibrillation. , 2004, American journal of physiology. Heart and circulatory physiology.

[22]  Hirofumi Tanaka,et al.  Unfavorable Effects of Resistance Training on Central Arterial Compliance: A Randomized Intervention Study , 2004, Circulation.

[23]  Zhen Yan,et al.  Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle. , 2004, American journal of physiology. Cell physiology.

[24]  D. Green,et al.  Effect of exercise training on endothelium‐derived nitric oxide function in humans , 2004, The Journal of physiology.

[25]  J. Koval,et al.  Longitudinal Study of Determinants of Dependence in an Elderly Population , 2004, Journal of the American Geriatrics Society.

[26]  W. Franke,et al.  Age- and fitness-related differences in limb venous compliance do not affect tolerance to maximal lower body negative pressure in men and women. , 2004, Journal of applied physiology.

[27]  D. Kass,et al.  Age and gender affect ventricular-vascular coupling during aerobic exercise. , 2004, Journal of the American College of Cardiology.

[28]  Robert J Petrella,et al.  Longitudinal changes in aerobic power in older men and women. , 2004, Journal of applied physiology.

[29]  K. Pyke,et al.  Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans. , 2004, Journal of applied physiology.

[30]  J. Cockcroft,et al.  Nitric Oxide and the Regulation of Large Artery Stiffness: From Physiology to Pharmacology , 2004, Hypertension.

[31]  M. Hopman,et al.  Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals. , 2004, American journal of physiology. Heart and circulatory physiology.

[32]  M. Joyner,et al.  Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans , 2004, The Journal of physiology.

[33]  W. Franke,et al.  Effects of age and fitness on tolerance to lower body negative pressure. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  D. Bluemke,et al.  Why is flow-mediated dilation dependent on arterial size? Assessment of the shear stimulus using phase-contrast magnetic resonance imaging. , 2004, American journal of physiology. Heart and circulatory physiology.

[35]  D. Simionescu,et al.  Involvement of matrix metalloproteinases and tenascin-C in elastin calcification. , 2004, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[36]  D. Proctor,et al.  Different vasodilator responses of human arms and legs , 2004, The Journal of physiology.

[37]  Dennis W Koch,et al.  Leg blood flow and VO2 during peak cycle exercise in younger and older women. , 2004, Medicine and science in sports and exercise.

[38]  M. Laughlin Joseph B. Wolfe Memorial lecture. Physical activity in prevention and treatment of coronary disease: the battle line is in exercise vascular cell biology. , 2004, Medicine and science in sports and exercise.

[39]  D. Proctor,et al.  Impaired leg vasodilation during dynamic exercise in healthy older women. , 2003, Journal of applied physiology.

[40]  Hirofumi Tanaka,et al.  Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. , 2003, Journal of applied physiology.

[41]  K. Foreman,et al.  Molecular mechanisms of replicative senescence in endothelial cells , 2003, Experimental Gerontology.

[42]  Liming Cai,et al.  Health, life expectancy, and health care spending among the elderly. , 2003, The New England journal of medicine.

[43]  M. Brown,et al.  Exercise and coronary vascular remodelling in the healthy heart. , 2003, Experimental physiology.

[44]  R. Richardson,et al.  Vascular and metabolic response to isolated small muscle mass exercise: effect of age. , 2003, American journal of physiology. Heart and circulatory physiology.

[45]  K. Chayama,et al.  Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans: Role of Endothelium-Dependent Nitric Oxide and Oxidative Stress , 2003, Circulation.

[46]  D. Proctor,et al.  Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation , 2003, The Journal of physiology.

[47]  B. Sonesson,et al.  Age affects proximal brachial artery stiffness; differential behavior within the length of the brachial artery? , 2003, Ultrasound in medicine & biology.

[48]  A. Mangoni,et al.  The cardiovascular system. , 2003, British journal of clinical pharmacology.

[49]  G. Schuler,et al.  Regular Physical Activity Improves Endothelial Function in Patients With Coronary Artery Disease by Increasing Phosphorylation of Endothelial Nitric Oxide Synthase , 2003, Circulation.

[50]  A. Quyyumi Prognostic value of endothelial function. , 2003, The American journal of cardiology.

[51]  Hirofumi Tanaka,et al.  Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. , 2003, Journal of applied physiology.

[52]  G. Sesti,et al.  Weight loss in combination with physical activity improves endothelial dysfunction in human obesity. , 2003, Diabetes care.

[53]  Andrew T. Wright,et al.  Detection of endothelial dysfunction with brachial artery ultrasound scanning. , 2003, American heart journal.

[54]  Jason D. Allen,et al.  Time course of improved flow-mediated dilation after short-term exercise training. , 2003, Medicine and science in sports and exercise.

[55]  D. Proctor,et al.  Leg Blood Flow During Submaximal Cycle Ergometry is not Reduced in Healthy Older Normally Active Men. , 2003, Journal of applied physiology.

[56]  R. Richardson,et al.  Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. , 2003, American journal of physiology. Heart and circulatory physiology.

[57]  D. Seals Habitual Exercise and the Age-Associated Decline in Large Artery Compliance , 2003, Exercise and sport sciences reviews.

[58]  Daniel Levy,et al.  Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. , 2003, Circulation.

[59]  Daniel Levy,et al.  Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. , 2003, Circulation.

[60]  K. Moreau,et al.  Greater Age-Related Reductions in Central Arterial Compliance in Resistance-Trained Men , 2003, Hypertension.

[61]  Y. Hellsten,et al.  Cytochrome P450 2C9 plays an important role in the regulation of exercise‐induced skeletal muscle blood flow and oxygen uptake in humans , 2003, The Journal of physiology.

[62]  Karen Steger-May,et al.  Effects of Exercise Training on Frailty in Community‐Dwelling Older Adults: Results of a Randomized, Controlled Trial , 2002, Journal of the American Geriatrics Society.

[63]  M. Safar,et al.  Aortic pulse wave velocity: an independent marker of cardiovascular risk. , 2002, The American journal of geriatric cardiology.

[64]  J. Isner,et al.  Constitutive Human Telomerase Reverse Transcriptase Expression Enhances Regenerative Properties of Endothelial Progenitor Cells , 2002, Circulation.

[65]  G. Balady,et al.  Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. , 2002, The American journal of cardiology.

[66]  Daniel Green,et al.  Assessment of brachial artery blood flow across the cardiac cycle: retrograde flows during cycle ergometry. , 2002, Journal of applied physiology.

[67]  Greta L. Hoetzer,et al.  Evidence for agonist‐specific endothelial vasodilator dysfunction with ageing in healthy humans , 2002, The Journal of physiology.

[68]  J. Guralnik,et al.  The Ankle Brachial Index Is Associated with Leg Function and Physical Activity: The Walking and Leg Circulation Study , 2002, Annals of Internal Medicine.

[69]  M. Joyner,et al.  Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? , 2002, The Journal of physiology.

[70]  K. Moreau,et al.  Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up. , 2002, Journal of applied physiology.

[71]  Jason D. Allen,et al.  Stability and reproducibility of brachial artery flow-mediated dilation. , 2002, Medicine and science in sports and exercise.

[72]  S. Prasad,et al.  Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. , 2002, Clinical science.

[73]  Todd J Brinton,et al.  Brachial artery distensibility and relation to cardiovascular risk factors in healthy young adults (The Bogalusa Heart Study). , 2002, The American journal of cardiology.

[74]  K. Yamauchi,et al.  Cardiovascular Responses to Lower Body Negative Pressure in the Elderly: Role of Reduced Leg Compliance , 2002, Gerontology.

[75]  R. Victor,et al.  Nitric oxide‐dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle , 2002, The Journal of physiology.

[76]  Hirofumi Tanaka,et al.  Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. , 2002, Journal of applied physiology.

[77]  E. Benjamin,et al.  Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. , 2002, Journal of the American College of Cardiology.

[78]  David J. Webb,et al.  Pulse‐Wave Analysis: Clinical Evaluation of a Noninvasive, Widely Applicable Method for Assessing Endothelial Function , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[79]  Olli T. Raitakari,et al.  Increased Aortic Intima-Media Thickness: A Marker of Preclinical Atherosclerosis in High-Risk Children , 2001, Circulation.

[80]  J. Skurnick,et al.  Age dependent aneuploidy and telomere length of the human vascular endothelium. , 2001, Atherosclerosis.

[81]  D. Green,et al.  Exercise training, vascular function, and functional capacity in middle-aged subjects. , 2001, Medicine and science in sports and exercise.

[82]  M. Joyner,et al.  From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. , 2001, Journal of applied physiology.

[83]  Joao A. C. Lima,et al.  The relationship between vascular wall shear stress and flow-mediated dilation: endothelial function assessed by phase-contrast magnetic resonance angiography. , 2001, Journal of the American College of Cardiology.

[84]  D. Harrison,et al.  Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways , 2001, Circulation research.

[85]  Hirofumi Tanaka,et al.  Central Arterial Compliance Is Associated With Age- and Habitual Exercise–Related Differences in Cardiovagal Baroreflex Sensitivity , 2001, Circulation.

[86]  W. Riley,et al.  Brachial Flow-Mediated Vasodilator Responses in Population-Based Research: Methods, Reproducibility and Effects of Age, Gender and Baseline Diameter , 2001, Journal of cardiovascular risk.

[87]  P. Clifford,et al.  The Paradox of Sympathetic Vasoconstriction in Exercising Skeletal Muscle , 2001, Exercise and sport sciences reviews.

[88]  D. Seals,et al.  Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men. , 2001, American journal of physiology. Heart and circulatory physiology.

[89]  M. Hijmering,et al.  Variability of flow mediated dilation: consequences for clinical application. , 2001, Atherosclerosis.

[90]  L. Ghiadoni,et al.  Age-Related Reduction of NO Availability and Oxidative Stress in Humans , 2001, Hypertension.

[91]  T. Gabbett,et al.  Does endurance training affect orthostatic responses in healthy elderly men? , 2001, Medicine and science in sports and exercise.

[92]  R. Vogel,et al.  Measurement of endothelial function by brachial artery flow-mediated vasodilation. , 2001, The American journal of cardiology.

[93]  Hirofumi Tanaka,et al.  Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men , 2001, The Journal of physiology.

[94]  D. Seals,et al.  Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. , 2001, American journal of physiology. Heart and circulatory physiology.

[95]  R. Wood,et al.  Modification of forearm vascular function following short-term handgrip exercise training. , 2001, International journal of sports medicine.

[96]  Hirofumi Tanaka,et al.  Age‐related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects , 2001, The Journal of physiology.

[97]  A. Dominiczak,et al.  Superoxide Excess in Hypertension and Aging: A Common Cause of Endothelial Dysfunction , 2001, Hypertension.

[98]  T. Lüscher,et al.  Enhanced Peroxynitrite Formation Is Associated with Vascular Aging , 2000, The Journal of experimental medicine.

[99]  D. Seals,et al.  Human ageing and the sympathoadrenal system , 2000, The Journal of physiology.

[100]  D. Green,et al.  Effect of aerobic and resistance exercise training on vascular function in heart failure. , 2000, American journal of physiology. Heart and circulatory physiology.

[101]  G. Semenza,et al.  Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity* , 2000, The Journal of Biological Chemistry.

[102]  Hirofumi Tanaka,et al.  Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men , 2000, Circulation.

[103]  M. Lefevre,et al.  Influence of age and normal plasma fibrinogen levels on flow-mediated dilation in healthy adults. , 2000, The American journal of cardiology.

[104]  Hirofumi Tanaka,et al.  Aging, Habitual Exercise, and Dynamic Arterial Compliance , 2000, Circulation.

[105]  Y. Hellsten,et al.  Inhibition of Nitric Oxide Synthesis by Systemic NG-Monomethyl-L-Arginine Administration in Humans: Effects on Interstitial Adenosine, Prostacyclin and Potassium Concentrations in Resting and Contracting Skeletal Muscle , 2000, Journal of Vascular Research.

[106]  R. Ross,et al.  Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. , 2000, Journal of applied physiology.

[107]  L. Ghiadoni,et al.  Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. , 2000, Circulation.

[108]  G. Schuler,et al.  Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. , 2000, JAMA.

[109]  D. Seals,et al.  Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. , 2000, American journal of physiology. Heart and circulatory physiology.

[110]  Hirofumi Tanaka,et al.  Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status. , 2000, American journal of physiology. Heart and circulatory physiology.

[111]  G. Schuler,et al.  Effect of exercise on coronary endothelial function in patients with coronary artery disease. , 2000, The New England journal of medicine.

[112]  R H Fagard,et al.  Effect of age on brachial artery wall properties differs from the aorta and is gender dependent: a population study. , 2000, Hypertension.

[113]  J. Bangsbo,et al.  Interstitial K(+) in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[114]  M. Hecker Endothelium-Derived Hyperpolarizing Factor-Fact or Fiction? , 2000, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[115]  G. Mancini,et al.  Temporal response of brachial artery dilation after occlusion and nitroglycerin. , 2000, The American journal of cardiology.

[116]  I. Keber,et al.  Physical training improves flow-mediated dilation in patients with the polymetabolic syndrome. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[117]  永井 洋士 Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia , 1999 .

[118]  J. Fleg,et al.  Enhanced endothelial vasoreactivity in endurance-trained older men. , 1999, Journal of applied physiology.

[119]  A. Dart,et al.  Exercise training increases basal nitric oxide production from the forearm in hypercholesterolemic patients. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[120]  G. Rådegran,et al.  Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects , 1999, Proceedings of the Nutrition Society.

[121]  M. Joyner,et al.  Measurement of limb venous compliance in humans: technical considerations and physiological findings. , 1999, Journal of applied physiology.

[122]  G. Kajiyama,et al.  Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. , 1999, Circulation.

[123]  S. Russell,et al.  Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men. , 1999, Circulation.

[124]  S. Bolz,et al.  Endothelium‐derived hyperpolarizing factor but not NO reduces smooth muscle Ca2+ during acetylcholine‐induced dilation of microvessels , 1999, British journal of pharmacology.

[125]  B. Kingwell,et al.  Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. , 1999, Diabetes.

[126]  D. Seals,et al.  Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. , 1999, Circulation.

[127]  R A Boileau,et al.  The physical activity scale for the elderly (PASE): evidence for validity. , 1999, Journal of clinical epidemiology.

[128]  B. Saltin,et al.  Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. , 1999, American journal of physiology. Heart and circulatory physiology.

[129]  F. Ohsuzu,et al.  Morning attenuation of endothelium‐dependent, flow‐mediated dilation in healthy young men: Possible connection to morning peak of cardiac events? , 1999, Clinical cardiology.

[130]  C. H. Chen,et al.  Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals. , 1999, Journal of the American College of Cardiology.

[131]  D. Ranney,et al.  Regulation of fiber size, oxidative potential, and capillarization in human muscle by resistance exercise. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[132]  J. Isner,et al.  Age-dependent impairment of angiogenesis. , 1999, Circulation.

[133]  F. Ohsuzu,et al.  Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease. , 1998, The American journal of cardiology.

[134]  G. Schuler,et al.  Exercise Capacity in Patients With Chronic Heart Failure Regular Physical Exercise Corrects Endothelial Dysfunction and Improves , 1998 .

[135]  C H Chen,et al.  Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. , 1998, Journal of the American College of Cardiology.

[136]  N. Labropoulos,et al.  Compensatory arterial enlargement is a common pathobiologic response in early atherosclerosis. , 1998, American journal of surgery.

[137]  J. Fleg,et al.  Expanded blood volumes contribute to the increased cardiovascular performance of endurance-trained older men. , 1998, Journal of applied physiology.

[138]  M. Joyner,et al.  Reduced leg blood flow during dynamic exercise in older endurance-trained men. , 1998, Journal of applied physiology.

[139]  M J Rosen,et al.  Predictors of age-associated decline in maximal aerobic capacity: a comparison of four statistical models. , 1998, Journal of applied physiology.

[140]  Carol Ewing Garber,et al.  ACSM Position Stand: The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults , 1998 .

[141]  J. Lekakis,et al.  Effects of acute cigarette smoking on endothelium-dependent arterial dilatation in normal subjects. , 1998, The American journal of cardiology.

[142]  Yoshifumi Takahashi,et al.  The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery. , 1998, Japanese circulation journal.

[143]  R. Bache,et al.  ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. , 1998, Circulation research.

[144]  M. Joyner,et al.  Reflex responses to regional venous pooling during lower body negative pressure in humans. , 1998, Journal of applied physiology.

[145]  W. Nichols,et al.  McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles , 1998 .

[146]  C. Swift,et al.  Impaired nitric oxide-mediated vasodilatation and total body nitric oxide production in healthy old age. , 1997, Clinical science.

[147]  Hirofumi Tanaka,et al.  Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. , 1997, Journal of applied physiology.

[148]  G. Plotnick,et al.  Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. , 1997, JAMA.

[149]  Hirofumi Tanaka,et al.  Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. , 1997, Journal of applied physiology.

[150]  G. Jennings,et al.  Norepinephrine spillover at rest and during submaximal exercise in young and old subjects. , 1997, Journal of applied physiology.

[151]  M. Laughlin,et al.  Short-term exercise training alters responses of porcine femoral and brachial arteries. , 1997, Journal of applied physiology.

[152]  J P Cooke,et al.  Nitric oxide synthase: role in the genesis of vascular disease. , 1997, Annual review of medicine.

[153]  M. Creager,et al.  Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. , 1997, Circulation.

[154]  Hirofumi Tanaka,et al.  Age and gender interactions in physiological functional capacity: insight from swimming performance. , 1997, Journal of applied physiology.

[155]  M. E. Cress,et al.  Continuous-scale physical functional performance in healthy older adults: a validation study. , 1996, Archives of physical medicine and rehabilitation.

[156]  L. Ghiadoni,et al.  Menopause is associated with endothelial dysfunction in women. , 1996, Hypertension.

[157]  Lehman Rm Poorly Controlled Diabetes , 1996 .

[158]  V. Huxley,et al.  Endothelium-Mediated Control of the Coronary Circulation , 1996 .

[159]  M. LeWinter,et al.  Skeletal muscle and cardiovascular adaptations to exercise conditioning in older coronary patients. , 1996, Circulation.

[160]  M. Creager,et al.  Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. , 1996, Hypertension.

[161]  T Bull,et al.  Exercise training enhances endothelial function in young men. , 1996, Journal of the American College of Cardiology.

[162]  H. Drexler,et al.  Physical training improves endothelial function in patients with chronic heart failure. , 1996, Circulation.

[163]  V. Convertino,et al.  Hormonal responses in elders experiencing pre-syncopal symptoms during head-up tilt before and after exercise training. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[164]  A. Yeung,et al.  Close relation of endothelial function in the human coronary and peripheral circulations. , 1995, Journal of the American College of Cardiology.

[165]  M. Joyner,et al.  Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. , 1995, The Journal of physiology.

[166]  L. M. Martín Arias,et al.  Age-related changes in contractile responses to noradrenaline in isolated blood vessels from rat and rabbit. , 1995, Journal of autonomic pharmacology.

[167]  D. Spiegelhalter,et al.  Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. , 1995, British heart journal.

[168]  Laughlin Mh Endothelium-mediated control of coronary vascular tone after chronic exercise training. , 1995 .

[169]  S. Diamond,et al.  Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. , 1995, The American journal of physiology.

[170]  David N. Proctor,et al.  Oxidative capacity of human muscle fiber types: Effects of age and training status , 1995 .

[171]  C. Jones,et al.  Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains. , 1995, Cardiovascular research.

[172]  StefanoTaddei,et al.  Aging and Endothelial Function in Normotensive Subjects and Patients With Essential Hypertension , 1995 .

[173]  A. Koller,et al.  Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Role of endothelial nitric oxide and prostaglandins. , 1995, Circulation research.

[174]  G. Plotnick,et al.  Technical aspects of evaluating brachial artery vasodilatation using high-frequency ultrasound. , 1995, The American journal of physiology.

[175]  E. Porreca,et al.  Impaired Left Ventricular Diastolic Function and Vascular Postischemic Vasodilation Associated with Microalbuminuria in IDDM Patients , 1995, Diabetes Care.

[176]  W E Haefeli,et al.  Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. , 1995, Circulation.

[177]  E. B. Smith Fibrinogen, fibrin and the arterial wall. , 1995, European heart journal.

[178]  J. Fleg,et al.  Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. , 1995, Journal of applied physiology.

[179]  A. Quyyumi,et al.  Contribution of Endothelium‐Derived Nitric Oxide to Exercise‐Induced Vasodilation , 1994, Circulation.

[180]  A. Takeshita,et al.  Role of Nitric Oxide in Exercise‐Induced Vasodilation of the Forearm , 1994, Circulation.

[181]  D. Celermajer,et al.  Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. , 1994, Journal of the American College of Cardiology.

[182]  R. Bourey,et al.  Effects of exercise training on alpha-adrenergic mediated pressor responses and baroreflex function in older subjects. , 1994, Journal of gerontology.

[183]  S. Eggener,et al.  Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. , 1994, The Journal of physiology.

[184]  N. Cable,et al.  Modification of forearm resistance vessels by exercise training in young men. , 1994, Journal of applied physiology.

[185]  J. Salonen,et al.  Ultrasonographic manifestations of common carotid atherosclerosis in elderly eastern Finnish men. Prevalence and associations with cardiovascular diseases and risk factors. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[186]  D. Spiegelhalter,et al.  Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. , 1994, Journal of the American College of Cardiology.

[187]  J. Michel,et al.  Effect of chronic ANG I-converting enzyme inhibition on aging processes. II. Large arteries. , 1994, The American journal of physiology.

[188]  A. Koller,et al.  Short-term daily exercise activity enhances endothelial NO synthesis in skeletal muscle arterioles of rats. , 1994, Journal of applied physiology.

[189]  B. Saltin,et al.  Cardiovascular responses during one- and two-legged exercise in middle-aged men. , 1994, Acta physiologica Scandinavica.

[190]  D. Cunningham,et al.  Exercise on-transient gas exchange kinetics are slowed as a function of age. , 1994, Medicine and science in sports and exercise.

[191]  D. Celermajer,et al.  Cigarette Smoking Is Associated With Dose‐Related and Potentially Reversible Impairment of Endothelium‐Dependent Dilation in Healthy Young Adults , 1993, Circulation.

[192]  T. Hintze,et al.  Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. , 1993, Circulation research.

[193]  A. Svanborg,et al.  Physiology of cardiovascular aging. , 1993, Physiological reviews.

[194]  J. Fleg,et al.  Effects of Age and Aerobic Capacit on Arterial Stiffness in Healthy Adults , 1993, Circulation.

[195]  D. Pendergast,et al.  Cardiovascular, neuromuscular, and metabolic alterations with age leading to frailty. , 1993, Journal of gerontology.

[196]  W. Kohrt,et al.  Differences in cardiovascular adaptations to endurance exercise training between older men and women. , 1993, Journal of applied physiology.

[197]  P. Raven,et al.  Chronic endurance exercise training: a condition of inadequate blood pressure regulation and reduced tolerance to LBNP. , 1993, Medicine and science in sports and exercise.

[198]  E. Lakatta,et al.  Cardiovascular regulatory mechanisms in advanced age. , 1993, Physiological reviews.

[199]  A. Ng,et al.  Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. , 1993, Hypertension.

[200]  Lutgarde Thijs,et al.  Age and the Hemodynamic Response to Posture and Exercise. , 1993, The American journal of geriatric cardiology.

[201]  A. Jette,et al.  The Physical Activity Scale for the Elderly (PASE): development and evaluation. , 1993, Journal of clinical epidemiology.

[202]  L. Rowell Human Cardiovascular Control , 1993 .

[203]  M. Joyner Physiological Limiting Factors and Distance Running: Influence of Gender and Age on Record Performances , 1993, Exercise and sport sciences reviews.

[204]  J. K. Lloyd,et al.  Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis , 1992, The Lancet.

[205]  J. Taylor,et al.  Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men. , 1992, The American journal of physiology.

[206]  D. Fitchett,et al.  Noninvasive determination of aortic input impedance and external left ventricular power output: a validation and repeatability study of a new technique. , 1992, Journal of the American College of Cardiology.

[207]  M. Joyner,et al.  Sympathetic modulation of blood flow and O2 uptake in rhythmically contracting human forearm muscles. , 1992, The American journal of physiology.

[208]  D. Kass,et al.  Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle. , 1992, Circulation research.

[209]  G. Meininger,et al.  Cellular mechanisms involved in the vascular myogenic response. , 1992, The American journal of physiology.

[210]  John O. Holloszy,et al.  Effects of Aging, Sex, and Physical Training on Cardiovascular Responses to Exercise , 1992, Circulation.

[211]  H. Bohlen,et al.  Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. , 1992, Journal of applied physiology.

[212]  M. Brown,et al.  Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. , 1992, Journal of applied physiology.

[213]  W. Kohrt,et al.  Effects of gender, age, and fitness level on response of VO2max to training in 60-71 yr olds. , 1991, Journal of applied physiology.

[214]  R. Virmani,et al.  Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. , 1991, The American journal of pathology.

[215]  L. Chambless,et al.  Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. , 1991, American journal of epidemiology.

[216]  K. Schechtman,et al.  Effects of Aging, Gender, and Physical Training on Peripheral Vascular Function , 1991, Circulation.

[217]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[218]  G Olivetti,et al.  Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. , 1991, Circulation research.

[219]  G. Rubanyi Endothelium‐derived relaxing and contracting factors , 1991, Journal of cellular biochemistry.

[220]  J D Carroll,et al.  Arterial mechanical properties in dilated cardiomyopathy. Aging and the response to nitroprusside. , 1991, The Journal of clinical investigation.

[221]  J. Kampine,et al.  Circulatory Physiology: The Essentials , 1990 .

[222]  I. Wakabayashi,et al.  Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. , 1990, Stroke.

[223]  B. Pannier,et al.  Flow-dependent vasodilation of brachial artery in essential hypertension. , 1990, The American journal of physiology.

[224]  C. Hayward,et al.  Noninvasive determination of age-related changes in the human arterial pulse. , 1989, Circulation.

[225]  B. Folkow,et al.  Myogenic mechanisms in the control of systemic resistance. Introduction and historical background. , 1989, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[226]  S Sasayama,et al.  Ventriculoarterial coupling in normal and failing heart in humans. , 1989, Circulation research.

[227]  M. Pollock,et al.  Cardiovascular responses of 70- to 79-yr-old men and women to exercise training. , 1989, Journal of applied physiology.

[228]  W. Frontera,et al.  Peripheral effects of endurance training in young and old subjects. , 1989, Journal of applied physiology.

[229]  D. Cunningham,et al.  Age-related changes in speed of walking. , 1988, Medicine and science in sports and exercise.

[230]  J. Pawelczyk,et al.  Cardiovascular responses to head-up tilt after an endurance exercise program. , 1988, Aviation, space, and environmental medicine.

[231]  J. Rowe Clinical consequences of age-related impairments in vascular compliance. , 1987, The American journal of cardiology.

[232]  S Sasayama,et al.  Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries. , 1987, Cardiovascular research.

[233]  R. Zelis,et al.  Enhanced maximal metabolic vasodilatation in the dominant forearms of tennis players. , 1986, Journal of applied physiology.

[234]  A. Breckenridge,et al.  The reproducibility of limb blood flow measurements in human volunteers at rest and after exercise by using mercury-in-Silastic strain gauge plethysmography under standardized conditions. , 1986, Clinical science.

[235]  P. Vanhoutte,et al.  Flow-induced release of endothelium-derived relaxing factor. , 1986, The American journal of physiology.

[236]  C. Rothe,et al.  Physiology of venous return. An unappreciated boost to the heart. , 1986, Archives of internal medicine.

[237]  R. Ross The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[238]  B. Hurley,et al.  A hemodynamic comparison of young and older endurance athletes during exercise. , 1985, Journal of applied physiology.

[239]  A P Avolio,et al.  Effects of age on ventricular-vascular coupling. , 1985, The American journal of cardiology.

[240]  R. Hoeldtke,et al.  Effects of aging on catecholamine metabolism. , 1985, The Journal of clinical endocrinology and metabolism.

[241]  B. Wallin,et al.  Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man. , 1983, Acta physiologica Scandinavica.

[242]  R. Hoeldtke,et al.  Assessment of norepinephrine secretion and production. , 1983, The Journal of laboratory and clinical medicine.

[243]  B. Folkow,et al.  Age-dependent alterations in the structurally determined vascular resistance, pre- to postglomerular resistance ratio and glomerular filtration capacity in kidneys, as studied in aging normotensive rats and spontaneously hypertensive rats. , 1983, Acta physiologica Scandinavica.

[244]  J. Reid,et al.  Noradrenaline release and clearance in relation to age and blood pressure in man , 1982, European journal of clinical investigation.

[245]  J. Vane,et al.  Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. , 1976, Prostaglandins.

[246]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[247]  R N Vaishnav,et al.  Static Linear and Nonlinear Elastic Properties of Normal and Arterialized Venous Tissue in Dog and Man , 1975, Circulation research.

[248]  H. Wolinsky,et al.  Long‐Term Effects of Hypertension on the Rat Aortic Wall and Their Relation to Concurrent Aging Changes: MORPHOLOGICAL AND CHEMICAL STUDIES , 1972, Circulation research.

[249]  L. Jorfeldt,et al.  Leg blood flow during exercise in man. , 1971, Clinical science.

[250]  R Peto,et al.  Effect of Age and High Blood Pressure on Barorefiex Sensitivity in Man , 1971, Circulation research.

[251]  R. Berne,et al.  Role of Adenine Nucleotides, Adenosine, and Inorganic Phosphate in the Regulation of Skeletal Muscle Blood Flow , 1971, Circulation research.

[252]  A. Robert,et al.  Molecular biology of elastin as related to aging and atherosclerosis. , 1970, Experimental gerontology.

[253]  Light Lh A recording spectrograph for analysing Doppler blood velocity signals (particularly from aortic flow) in real time. , 1970 .

[254]  E. C. Hammond,et al.  Thickening of walls of arterioles and small arteries in relation to age and smoking habits. , 1968, The New England journal of medicine.

[255]  A. Guyton,et al.  Textbook of Medical Physiology , 1961 .

[256]  M. Higuchi,et al.  Cardiovascular changes associated with decreased aerobic capacity and aging in long-distance runners , 2006, European Journal of Applied Physiology and Occupational Physiology.

[257]  R. Busse,et al.  Endothelial aging. , 2005, Cardiovascular research.

[258]  E. Evans,et al.  Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. , 2005, Journal of applied physiology.

[259]  B. Parker,et al.  Age and regional specificity of peak limb vascular conductance in women. , 2005, Journal of applied physiology.

[260]  David A. Kass,et al.  Age-related Changes in Venticular–Arterial Coupling: Pathophysiologic Implications , 2004, Heart Failure Reviews.

[261]  E. Lakatta Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons , 2004, Heart Failure Reviews.

[262]  J. Docherty,et al.  Age-related alterations in α1- and β-adrenoceptors mediated responsiveness of rat aorta , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[263]  Mary C. Meyer,et al.  Maximal voluntary and functional performance levels needed for independence in adults aged 65 to 97 years. , 2003, Physical therapy.

[264]  D. Green,et al.  Exercise and the Nitric Oxide Vasodilator System , 2003, Sports medicine.

[265]  E. Stankevičius,et al.  [Role of nitric oxide and other endothelium-derived factors]. , 2003, Medicina.

[266]  T. Koyama,et al.  Time-course changes in arteriolar and venular portions of capillary in young treadmill-trained rats. , 2001, Acta physiologica Scandinavica.

[267]  E. Lakatta,et al.  Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats. , 1999, Hypertension.

[268]  Hirofumi Tanaka,et al.  Absence of age-related increase in central arterial stiffness in physically active women. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[269]  T. Länne,et al.  Reduced venous compliance in lower limbs of aging humans and its importance for capacitance function , 1998 .

[270]  R. Hughson,et al.  Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery , 1997 .

[271]  J. Michel,et al.  Circulating and cellular markers of endothelial dysfunction with aging in rats. , 1997, American Journal of Physiology.

[272]  V. Huxley,et al.  Endothelium-medicated control of the coronary circulation. Exercise training-induced vascular adaptations. , 1996, Sports medicine.

[273]  M. Laughlin Endothelium-mediated control of coronary vascular tone after chronic exercise training. , 1995, Medicine and science in sports and exercise.

[274]  A S Jackson,et al.  Changes in aerobic power of men, ages 25-70 yr. , 1995, Medicine and science in sports and exercise.

[275]  A M Jette,et al.  The disablement process. , 1994, Social science & medicine.

[276]  P. Wagner,et al.  Gas exchange and peripheral diffusion limitation. , 1992, Medicine and science in sports and exercise.

[277]  T R Miller,et al.  Exercise training improves left ventricular systolic function in older men. , 1991, Circulation.

[278]  F. Kobayashi,et al.  Age-related changes of sympathetic outflow to muscles in humans. , 1991, Journal of gerontology.

[279]  J. Docherty,et al.  Age-related alterations in alpha 1- and beta-adrenoceptors mediated responsiveness of rat aorta. , 1987, Naunyn-Schmiedeberg's archives of pharmacology.

[280]  D. Goldstein,et al.  Age-dependence of hypertensive-normotensive differences in plasma norepinephrine. , 1983, Hypertension.

[281]  N. Simionescu,et al.  The Cardiovascular System , 1983 .

[282]  D. Costill,et al.  Fractional utilization of the aerobic capacity during distance running. , 1973, Medicine and science in sports.

[283]  D. Hokanson,et al.  Ultrasonic arteriography. , 1971, Archives of surgery.

[284]  A. Guyton,et al.  Determination of cardiac output by equating venous return curves with cardiac response curves. , 1955, Physiological reviews.