Simultaneous Attenuation and Scatter Corrections in Small Animal PET Imaging

The aim of this work is to simultaneously correct for attenuation and scatter in positron emission tomography (PET) by analytically assessing the distribution of the scattered photons using the emission images, the probability of scatter interactions and the detection efficiency. Above the usual lower energy threshold of 300 keV, the attenuated photons are dominantly those which have undergone a Compton scattering. A simple equation is established by considering that each voxel in the image is the measurement of the transmitted photons through the subject, added to the contribution from the other sources by means of their scatter. The solution of this equation allows to correct from scatter and attenuation simultaneously. This new method was applied for data measured with the Sherbrooke small animal PET scanner in line sources, hot spot phantoms, and in rat hearts and tumors.

[1]  S. Grootoonk,et al.  Correction for scatter using a dual energy window technique with a tomograph operated without septa , 1991, Conference Record of the 1991 IEEE Nuclear Science Symposium and Medical Imaging Conference.

[2]  C. C. Watson.  New, faster, image-based scatter correction for 3D PET , 1999 .

[3]  Mark Lubberink,et al.  Non-stationary convolution subtraction scatter correction with a dual-exponential scatter kernel for the Hamamatsu SHR-7700 animal PET scanner. , 2004, Physics in medicine and biology.

[4]  V Sossi,et al.  A phantom study evaluating the quantitative aspect of 3D PET imaging of the brain. , 1998, Physics in medicine and biology.

[5]  Magnus Dahlbom,et al.  Performance analysis of an improved 3-D PET Monte Carlo simulation and scatter correction , 2000 .

[6]  H. Zaidi.  Comparative evaluation of scatter correction techniques in 3D positron emission tomography , 2000, European Journal of Nuclear Medicine.

[7]  C. Bohm,et al.  Correction for Scattered Radiation in a Ring Detector Positron Camera by Integral Transformation of the Projections , 1983, Journal of computer assisted tomography.

[8]  G Brix,et al.  Investigation of scattered radiation in 3D whole-body positron emission tomography using Monte Carlo simulations. , 1999, Physics in medicine and biology.

[9]  R Lecomte,et al.  Assessment of scatter components in high-resolution PET: correction by nonstationary convolution subtraction. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  S R Meikle,et al.  A convolution-subtraction scatter correction method for 3D PET. , 1994, Physics in medicine and biology.

[11]  Joel S. Karp,et al.  Special Papers Section-NPSS/Medical Imaging Conference Cross-Plane Scattering Correction-Point Source Deconvolution in PET , 1991 .

[12]  D. Newport,et al.  Evaluation of simulation-based scatter correction for 3-D PET cardiac imaging , 1995 .

[13]  Roger Lecomte,et al.  Energy dependence of nonstationary scatter subtraction-restoration in high resolution PET , 1999, IEEE Transactions on Medical Imaging.

[14]  Roger Lecomte,et al.  Initial results from the Sherbrooke avalanche photodiode positron tomograph , 1996 .

[15]  J. G. Rogers,et al.  Object shape dependent scatter simulations for PET , 1991 .

[16]  Joel S. Karp,et al.  Composite Dual Window Scattering Correction Technique In PET , 1993, 1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference.

[17]  R. Trebossen,et al.  A PET scatter correction using simultaneous acquisitions with low and high lower energy thresholds , 1993, 1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference.

[18]  R. D. Evans,et al.  Atomic Nucleus , 2020, Definitions.

[19]  M. Bentourkia,et al.  Cross-validation stopping rule for ML-EM reconstruction of dynamic PET series: effect on image quality and quantitative accuracy , 1999, 1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019).

[20]  Roger Lecomte,et al.  Object and detector scatter-function dependence on energy and position in high resolution PET , 1995 .

[21]  Gunnar Brix,et al.  Fast implementation of the single scatter simulation algorithm and its use in iterative image reconstruction of PET data , 1999, 1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019).

[22]  M E Bellemann,et al.  Monte Carlo-based analysis of PET scatter components. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  R Lecomte,et al.  Nonstationary scatter subtraction-restoration in high-resolution PET. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[24]  Joel S. Karp,et al.  Triple energy window scatter correction technique in PET , 1994, IEEE Trans. Medical Imaging.

[25]  L. G. Hiltz,et al.  Scatter correction for three-dimensional PET based on an analytic model dependent on source and attenuating object. , 1994, Physics in medicine and biology.

[26]  R. Lecomte,et al.  Geometry Study of a High Resolution PET Detection System Using Small Detectors , 1984, IEEE Transactions on Nuclear Science.

[27]  J. Ollinger.  Model-based scatter correction for fully 3D PET. , 1996, Physics in medicine and biology.

[28]  Sibylle Ziegler,et al.  Scatter correction in the transaxial slices of a whole-body positron emission tomograph , 1993 .