Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration

[1]  B. Bell,et al.  Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice , 2013, PloS one.

[2]  M. Borrello,et al.  TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells , 2011, Oncogene.

[3]  C. Gialeli,et al.  Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting , 2011, The FEBS journal.

[4]  Kenneth M. Yamada,et al.  Random versus directionally persistent cell migration , 2009, Nature Reviews Molecular Cell Biology.

[5]  Laura A. Sullivan,et al.  Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts , 2009, Molecular Cancer Therapeutics.

[6]  O. Fodstad,et al.  Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling , 2008, Pigment cell & melanoma research.

[7]  W. Stetler-Stevenson.  Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities , 2008, Science Signaling.

[8]  J. Fleming,et al.  Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. , 2008, Cancer research.

[9]  T. Byzova,et al.  Angiogenesis in melanoma. , 2007, Seminars in oncology.

[10]  M. de Waele,et al.  Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3. , 2007, Haematologica.

[11]  Niels Galjart,et al.  Differential effects of matrix and growth factors on endothelial and fibroblast motility: Application of a modified cell migration assay , 2006, Journal of cellular biochemistry.

[12]  Xu-wen Liu,et al.  Novel functions of TIMPs in cell signaling , 2006, Cancer and Metastasis Reviews.

[13]  S. Johansson,et al.  Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A , 2005, Melanoma research.

[14]  Yukinori Endo,et al.  A Rac switch regulates random versus directionally persistent cell migration , 2005, The Journal of cell biology.

[15]  C. Figdor,et al.  Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice , 1991, Clinical & Experimental Metastasis.

[16]  Richard A. Firtel,et al.  Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement , 2004, The Journal of cell biology.

[17]  B. Haye,et al.  TIMPs as multifacial proteins. , 2004, Critical reviews in oncology/hematology.

[18]  C. Brigati,et al.  Tissue inhibitors of metalloproteases: Regulation and biological activities , 2004, Clinical & Experimental Metastasis.

[19]  C. Butterfield,et al.  Structural and Functional Uncoupling of the Enzymatic and Angiogenic Inhibitory Activities of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) , 2003, Journal of Biological Chemistry.

[20]  D. H. Ma,et al.  Inhibition of fibroblast-induced angiogenic phenotype of cultured endothelial cells by the overexpression of tissue inhibitor of metalloproteinase (TIMP)-3. , 2003, Journal of Biomedical Sciences.

[21]  P. Wingfield,et al.  TIMP-2 Mediated Inhibition of Angiogenesis An MMP-Independent Mechanism , 2003, Cell.

[22]  R. Kalluri.  Basement membranes: structure, assembly and role in tumour angiogenesis , 2003, Nature reviews. Cancer.

[23]  P. Carmeliet.  Angiogenesis in health and disease , 2003, Nature Medicine.

[24]  Michael Streit,et al.  Angiogenesis, lymphangiogenesis, and melanoma metastasis , 2003, Oncogene.

[25]  L. Claesson‐Welsh,et al.  A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 , 2003, Nature Medicine.

[26]  B. Simon,et al.  Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. , 2003, The Journal of clinical endocrinology and metabolism.

[27]  A. Davidoff,et al.  Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model. , 2002, Blood.

[28]  Richard A. Firtel,et al.  Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis , 2002, Cell.

[29]  R. Firtel,et al.  Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. Kuwano,et al.  Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL‐1α , 2000 .

[31]  M. Kuwano,et al.  Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha. , 2000, International journal of cancer.

[32]  D. Ruiter,et al.  Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression , 1999, British Journal of Cancer.

[33]  A. Baker,et al.  Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3 , 1999, British Journal of Cancer.

[34]  J. Herman,et al.  Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. , 1999, Cancer research.

[35]  H. Nagase.  Cell surface activation of progelatinase A (proMMP-2) and cell migration , 1998, Cell Research.

[36]  V. Kähäri,et al.  Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. , 1998, Cancer research.

[37]  A. Baker,et al.  Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis. , 1998, The Journal of clinical investigation.

[38]  D J Ruiter,et al.  An improved procedure to quantify tumour vascularity using true colour image analysis. Comparison with the manual hot‐spot procedure in a human melanoma xenograft model , 1998, The Journal of pathology.

[39]  D. Benezra.  Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3. , 1997, Investigative ophthalmology & visual science.

[40]  J. A. van der Laak,et al.  Vascular density in melanoma xenografts correlates with vascular permeability factor expression but not with metastatic potential. , 1997, British Journal of Cancer.

[41]  B. Olsen,et al.  A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth. , 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[42]  J. Folkman.  Clinical Applications of Research on Angiogenesis , 1995 .

[43]  S. Apte,et al.  The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family (*) , 1995, The Journal of Biological Chemistry.

[44]  J. Folkman.  Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. , 1995, The New England journal of medicine.

[45]  J. Folkman.  Angiogenesis in cancer, vascular, rheumatoid and other disease , 1995, Nature Medicine.

[46]  A. Shinagawa,et al.  Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2). , 1994, Journal of cell science.

[47]  R. Khokha,et al.  Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. , 1994, The Journal of biological chemistry.

[48]  A. Logan,et al.  Angiogenesis , 1993, The Lancet.

[49]  A. Eisen,et al.  Growth stimulation of human keratinocytes by tissue inhibitor of metalloproteinases. , 1991, The Journal of investigative dermatology.

[50]  J. Trinkaus,et al.  Fundulus deep cells: directional migration in response to epithelial wounding. , 1988, Developmental biology.

[51]  E. Jaffe,et al.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. , 1973, The Journal of clinical investigation.