Genital and reproductive organ complications of Crohn disease: technical considerations as it relates to perianal disease, imaging features, and implications on management

ObjectiveA relatively large proportion of patients with Crohn disease (CD) develop complications including abscess formation, stricture, and penetrating disease. A subset of patients will have genital and reproductive organ involvement of CD, resulting in significant morbidity. These special circumstances create unique management challenges that must be tailored to the activity, location, and extent of disease. Familiarity with the epidemiology, pathogenesis, imaging features, and treatment strategies for patients with genital CD can aid imaging diagnoses and guide appropriate patient management. The purpose of this study is to illustrate the spectrum of CD in the genital tract and reproductive organs and discuss the complex management strategies in these patients as it relates to imaging.ConclusionGiven the impact on patient outcome and treatment planning, familiarity with the epidemiology, pathogenesis, imaging features, and treatment of patients with genital Crohn disease can aid radiologic diagnoses and guide appropriate patient management.

[1]  J. Mcaninch,et al.  Rectourethral fistulae: the perineal approach. , 2006, Journal of the American College of Surgeons.

[2]  A. Zinsmeister,et al.  The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. , 2002, Gastroenterology.

[3]  Robert D. Harris,et al.  ACR Appropriateness Criteria® Acute Pelvic Pain in the Reproductive Age Group. , 2011, Ultrasound quarterly.

[4]  S. Hanauer,et al.  AGA technical review on perianal Crohn's disease. , 2003, Gastroenterology.

[5]  Jon A. van Heerden,et al.  Shackelford's Surgery of the Alimentary Tract , 1992 .

[6]  D. Hoyo,et al.  MR imaging evaluation of perianal fistulas: spectrum of imaging features. , 2012, Radiographics : a review publication of the Radiological Society of North America, Inc.

[7]  E. S. Amis,et al.  Radiology of male periurethral structures. , 1988, AJR. American journal of roentgenology.

[8]  M. Harisinghani,et al.  Imaging of penile neoplasms. , 2005, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  H. Sokol,et al.  Crohn's disease of the vulva. , 2014, Journal of Crohn's & colitis.

[10]  G. D'Haens,et al.  Optimising monitoring in the management of Crohn's disease: a physician's perspective. , 2013, Journal of Crohn's & colitis.

[11]  L. Peyrin-Biroulet,et al.  Review article: the natural history of postoperative Crohn's disease recurrence , 2012, Alimentary pharmacology & therapeutics.

[12]  W. Rowe,et al.  Remicade® Does Not Abolish the Need for Surgery in Fistulizing Crohn’s Disease , 2002, Diseases of the colon and rectum.

[13]  J. Fleshman,et al.  Use of endoanal ultrasound in patients with rectovaginal fistulas , 1999, Diseases of the colon and rectum.

[14]  V. Mittal,et al.  Setons in the Treatment of Anal Fistula: Review of Variations in Materials and Techniques , 2012, Digestive Surgery.

[15]  C. Bernstein,et al.  Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management , 2009, Inflammatory bowel diseases.

[16]  Robert T. Lewis,et al.  Efficacy and complications of surgery for Crohn's disease. , 2010, Gastroenterology & hepatology.

[17]  F. Giuliante,et al.  Incidence, diagnosis, and treatment of enteric and colorectal fistulae in patients with Crohn's disease. , 1993, Annals of surgery.

[18]  M. Varma,et al.  Rectovaginal and Rectourethral Fistulas , 2011 .

[19]  B. Sands,et al.  Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. , 2004, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[20]  M. Silverman,et al.  Scrotal emergencies. , 2011, Emergency medicine clinics of North America.

[21]  S. Eisenhammer A new approach to the anorectal fistulous abscess based on the high intermuscular lesion. , 1958, Surgery, gynecology & obstetrics.

[22]  F. Remzi,et al.  Management and Outcome of Pouch-Vaginal Fistulas After IPAA Surgery , 2014, Diseases of the colon and rectum.

[23]  M. Regueiro,et al.  Treatment of Perianal Fistulizing Crohn's Disease with Infliximab Alone or as an Adjunct to Exam Under Anesthesia with Seton Placement , 2003, Inflammatory bowel diseases.

[24]  R. Damstra,et al.  Penile and scrotal lymphedema as an unusual presentation of Crohn's disease: case report and review of the literature. , 2012, Lymphology.

[25]  H. Kitamura,et al.  Rectourinary Fistula after Radical Prostatectomy: Review of the Literature for Incidence, Etiology, and Management , 2011, Prostate cancer.

[26]  R. Ng,et al.  Pelvi-perineal flap reconstruction: normal imaging appearances and post-operative complications on cross-sectional imaging , 2011, Insights into imaging.

[27]  D. Mitchell,et al.  ACR Appropriateness Criteria® Acute Pelvic Pain in the Reproductive Age Group. , 2011, Ultrasound quarterly.

[28]  S. Steele,et al.  Operative considerations for rectovaginal fistulas. , 2015, World journal of gastrointestinal surgery.

[29]  J. Fleshman,et al.  Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. , 1993, Surgery.

[30]  J. Morris,et al.  MR imaging classification of perianal fistulas and its implications for patient management. , 2000, Radiographics : a review publication of the Radiological Society of North America, Inc.

[31]  Ajay Singh,et al.  Fournier gangrene: role of imaging. , 2008, Radiographics : a review publication of the Radiological Society of North America, Inc.

[32]  T. Hull,et al.  Contemporary surgical management of rectovaginal fistula in Crohn's disease. , 2014, World journal of gastrointestinal pathophysiology.

[33]  J. Nickel Prostatitis and Related Conditions, Orchitis, and Epididymitis , 2012 .

[34]  D. Edwards,et al.  Ovarian Crohn's disease: contiguous or metastatic? , 2006, Inflammatory bowel diseases.