The effects of methylpentynol on ethanol drinking and on water metabolism in rats

According to Richter (1957) the ability of rats to make dietary selections depends on the sense of taste more than on the effects produced by substances after ingestion. As methylpentynol apparently dulLs the sense of discrimination of rats (Halpern & Lehmann, 1957; Watson, 1958) it was thought of interest to see whether the administration of the drug to rats might change the distaste which they usually have for comparatively concentrated solutions of ethanol and induce them to drink solutions which they normally refuse. This in turn has led to study of the effect of methylpentynol on the water metabolism of rats. A preliminary account of this investigation has been communicated to the Physiological Society (Dicker, 1958).

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