Transmission through the female line of a mechanism constraining human fetal growth.

Cross-breeding experiments between large and small strains of mammals have shown the powerful influence of the maternal organism on the control of fetal growth. The prepotency of a maternal regulator has also been demonstrated in humans. Our earlier studies indicated that this regulator acts by means of constraint; there is no equivalent accelerating mechanism. Data on 1092 siblings and 5207 paternal and maternal relatives of 986 probands show different patterns of birthweight among families ascertained, respectively, through very large and very small babies. When constraint is relaxed the Mendelian laws of inheritance are clearly followed. At the lower extreme there is evidence for the transmission of constraint through the female line only. This could be due to the maternal genotype, but our data suggest that a non-Mendelian path might also be involved. Such a process would be adaptive, facilitating fairly fast changes in fetal growth rate as the conditions under which a population lives deteriorate or improve.

[1]  D. M. Joubert,et al.  A crossbreeding experiment with cattle, with special reference to the maternal effect in South Devon—Dexter crosses , 1958, The Journal of Agricultural Science.

[2]  O. Venge.  STUDIES OF THE MATERNAL INFLUENCE ON THE BIRTH WEIGHT IN RABBITS , 1950 .

[3]  H. Hoffman,et al.  The tendency to repeat gestational age and birth weight in successive births. , 1979, American journal of obstetrics and gynecology.

[4]  A. Davies,et al.  Birth Weight in Israel, 1968–70 , 1975, Journal of Biosocial Science.

[5]  L. Penrose,et al.  Birth weight, gestation time and survival in sibs. , 1952, Annals of eugenics.

[6]  N. B. Jones.  Natural selection and birthweight. , 1978, Annals of human biology.

[7]  A. Scott,et al.  Growth in the first four years: IV. Correlations with parental measures in small-for-dates and large-for-dates babies. , 1982, Early human development.

[8]  By NEWTON E. Morton.  THE INHERITANCE OF HUMAN BIRTH WEIGHT* , 1955, Annals of human genetics.

[9]  K. Méhes,et al.  Maternal regulation of fetal growth. , 1983, Acta paediatrica Hungarica.

[10]  E. Robson.  BIRTH WEIGHT IN COUSINS , 1955, Annals of human genetics.

[11]  F. Johnstone,et al.  Familial Trends in Low Birth Weight , 1974, British medical journal.

[12]  M. J. Hollingsworth.  Observations on the birth weights and survival of African babies: Single births , 1964, Annals of human genetics.

[13]  S. Selvin,et al.  Four factors influencing birth weight. , 1971, British journal of preventive & social medicine.

[14]  C. Ounsted,et al.  Rate of Intra-uterine Growth , 1968, Nature.

[15]  A. Davies,et al.  Birth Weight In Israel, 1968–70 I. Effects of Birth Order and Maternal Origin , 1974, Journal of Biosocial Science.

[16]  P. Gruenwald,et al.  INFLUENCE OF ENVIRONMENTAL FACTORS ON FŒTAL GROWTH IN MAN , 1967 .

[17]  A. Scott,et al.  Risk factors associated with small‐for‐dates and large‐for‐dates infants , 1985 .

[18]  L. Lubchenco,et al.  INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION. , 1963, Pediatrics.

[19]  P. Adelstein,et al.  ANTENATAL IDENTIFICATION OF WOMEN AT INCREASED RISK OF BEING DELIVERED OF A LOW BIRTH WEIGHT INFANT AT TERM , 1978, British journal of obstetrics and gynaecology.

[20]  R. Carr-Hill,et al.  Birthweight and paternal height , 1983, British journal of obstetrics and gynaecology.

[21]  Meredith Hv.  Body weight at birth of viable human infants: a worldwide comparative treatise. , 1970 .

[22]  Arthur Walton,et al.  The maternal effects on growth and conformation in Shire horse-Shetland pony crosses. , 1938 .

[23]  P. Yudkin,et al.  High birthweight in an ethnic group of low socioeconomic status , 1983, British journal of obstetrics and gynaecology.