The enteric nerve system as target of regulated and emerging food-associated mycotoxins.

Food and feed are frequently contaminated by numerous regulated and emerging mycotoxins. Humans and animals are thus exposed daily to mycotoxins through the oral route making of the gut the first and the more exposed tissue. Although many studies have evaluated and demonstrated the impact of mycotoxins on the intestinal epithelial cells (IECs) and on the brain cells, surprisingly only few studies have investigated their impact on cells of the enteric nerve system (ENS). In the present work, we measured the impact of major regulated and emerging mycotoxins (18 mycotoxins in total) on the proliferation and viability of normal rat enteric glial cells (EGCs) in vitro. On the 18 mycotoxins tested, 12 were found toxic with anti-proliferative and/or cytotoxic effects observed at doses ranging from 0.19 to 118 μM and 0.4 to 59.59 μM, respectively. It can be concluded that alterations of the EGCs caused by at least some mycotoxins may participate in their global impact on the gut and the full organism.

[1]  A. Jabeen,et al.  Furan-Conjugated Tripeptides as Potent Antitumor Drugs , 2020, Biomolecules.

[2]  C. Pellegrini,et al.  Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease , 2020, International journal of molecular sciences.

[3]  F. Caloni,et al.  Beauvericin and Enniatins: In Vitro Intestinal Effects , 2020, Toxins.

[4]  Yanan Gao,et al.  The Compromised Intestinal Barrier Induced by Mycotoxins , 2020, Toxins.

[5]  K. Kuča,et al.  The Neurotoxicity of Trichothecenes T-2 Toxin and Deoxynivalenol (DON): Current Status and Future Perspectives. , 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[6]  S. Gonkowski,et al.  Mycotoxins and the Enteric Nervous System , 2020, Toxins.

[7]  P. Piccerelle,et al.  Synthesis and Evaluation of the Antibacterial Activities of 13-Substituted Berberine Derivatives , 2020, Antibiotics.

[8]  M. Natali,et al.  Chronic ingestion of deoxynivalenol‐contaminated diet dose‐dependently decreases the area of myenteric neurons and gliocytes of rats , 2019, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[9]  Pascal G. P. Martin,et al.  Co-Occurrence of DON and Emerging Mycotoxins in Worldwide Finished Pig Feed and Their Combined Toxicity in Intestinal Cells , 2019, Toxins.

[10]  E. Baydoun,et al.  Comparative Structure–Activity Analysis of the Antimicrobial Activity, Cytotoxicity, and Mechanism of Action of the Fungal Cyclohexadepsipeptides Enniatins and Beauvericin , 2019, Toxins.

[11]  V. Fessard,et al.  Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells , 2019, Marine drugs.

[12]  Shumin Yu,et al.  Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function , 2019, International journal of molecular sciences.

[13]  I. Oswald,et al.  Effects of Mycotoxins on the Intestine , 2019, Toxins.

[14]  E. Baydoun,et al.  Aurone derivatives as promising antibacterial agents against resistant Gram-positive pathogens. , 2019, European journal of medicinal chemistry.

[15]  R. Heuckeroth,et al.  Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. , 2019, Annual review of physiology.

[16]  I. Oswald,et al.  Review article: Role of satiety hormones in anorexia induction by Trichothecene mycotoxins. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[17]  S. Gonkowski,et al.  The Impact of T-2 Toxin on Vasoactive Intestinal Polypeptide-Like Immunoreactive (VIP-LI) Nerve Structures in the Wall of the Porcine Stomach and Duodenum , 2018, Toxins.

[18]  D. Olive,et al.  Enediynes bearing polyfluoroaryl sulfoxide as new antiproliferative agents with dual targeting of microtubules and DNA. , 2018, European journal of medicinal chemistry.

[19]  P. Naveilhan,et al.  The multiple faces of inflammatory enteric glial cells: is Crohn's disease a gliopathy? , 2018, American journal of physiology. Gastrointestinal and liver physiology.

[20]  S. Gonkowski,et al.  The Influence of Low Doses of Zearalenone and T-2 Toxin on Calcitonin Gene Related Peptide-Like Immunoreactive (CGRP-LI) Neurons in the ENS of the Porcine Descending Colon , 2017, Toxins.

[21]  S. Wehner,et al.  Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases , 2015, Inflammatory bowel diseases.

[22]  S. Gonkowski,et al.  Zearalenone-induced changes in the lymphoid tissue and mucosal nerve fibers in the porcine ileum. , 2015, Polish journal of veterinary sciences.

[23]  K. Ghareeb,et al.  Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine , 2015, Journal of applied toxicology : JAT.

[24]  S. Stoev.  Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction. , 2015, Environmental toxicology and pharmacology.

[25]  R. De Giorgio,et al.  Enteric glial cells: recent developments and future directions. , 2014, Gastroenterology.

[26]  I. Oswald,et al.  Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review , 2014, Toxins.

[27]  J. Groopman,et al.  Public health impacts of foodborne mycotoxins. , 2014, Annual review of food science and technology.

[28]  M. Maresca.  From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol , 2013, Toxins.

[29]  L. Mounien,et al.  Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target , 2012, Toxins.

[30]  Xiao-jun Guo,et al.  The ribotoxin deoxynivalenol affects the viability and functions of glial cells , 2011, Glia.

[31]  K. Uetsuka,et al.  Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways , 2011, International journal of molecular sciences.

[32]  J. Fantini,et al.  Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases. , 2010, Toxicon : official journal of the International Society on Toxinology.

[33]  Xiao-jun Guo,et al.  The food-associated fungal neurotoxin ochratoxin A inhibits the absorption of glutamate by astrocytes through a decrease in cell surface expression of the excitatory amino-acid transporters GLAST and GLT-1. , 2010, Neurotoxicology.

[34]  Catherine B. Purzycki,et al.  Fungal toxins and multiple sclerosis: A compelling connection , 2010, Brain Research Bulletin.

[35]  M. Sofroniew,et al.  Starring roles for astroglia in barrier pathologies of gut and brain , 2007, Laboratory Investigation.

[36]  J. Frisvad,et al.  Important mycotoxins and the fungi which produce them. , 2006, Advances in experimental medicine and biology.