Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
暂无分享,去创建一个
Ning Wang | Yibin Feng | Yuanjun Lu | Sha Li | H. Tan | Y. Chan | Yibin Feng | Sha Li
[1] Ni Zeng,et al. LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis , 2020, Aging.
[2] C. Brennan,et al. LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement. , 2020, Neuro-oncology.
[3] Wei Wang,et al. The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically , 2020, Oncogene.
[4] T. Boettger,et al. RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice , 2020, Oncogene.
[5] Z. Zeng,et al. Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA , 2020, Molecular Cancer.
[6] Duan Ma,et al. SLC34A2 simultaneously promotes papillary thyroid carcinoma growth and invasion through distinct mechanisms , 2020, Oncogene.
[7] Jae Cheol Lee,et al. Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4. , 2020, Cancer letters.
[8] V. Lazar,et al. A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells , 2020, Cancers.
[9] Tianxin Lin,et al. circRNA circFUT8 Upregulates Krüpple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p , 2020, Molecular therapy oncolytics.
[10] M. Reese,et al. Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma , 2020, Cancers.
[11] N. Wong,et al. Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. , 2019, Gastroenterology.
[12] B. Baradaran,et al. microRNA-181 serves as a dual-role regulator in the development of human cancers. , 2019, Free radical biology & medicine.
[13] E. Blanco,et al. The Bivalent Genome: Characterization, Structure, and Regulation. , 2019, Trends in genetics : TIG.
[14] E. Filippi-Chiela,et al. Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence , 2019, Oncogene.
[15] G. Calin,et al. Current concepts of non-coding RNA regulation of immune checkpoints in cancer. , 2019, Molecular aspects of medicine.
[16] Xiaofan Ding,et al. Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. , 2019, Gastroenterology.
[17] Xin Zhang,et al. RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial–mesenchymal transition and promotes metastasis of colorectal cancer , 2019, Cell Death & Disease.
[18] F. Ay,et al. NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains , 2019, Nature Communications.
[19] Yong Li,et al. Exosomes in Cancer Radioresistance , 2019, Front. Oncol..
[20] P. Porcu,et al. Preclinical Targeting of MicroRNA-214 in Cutaneous T-Cell Lymphoma. , 2019, The Journal of investigative dermatology.
[21] Zu-hua Gao,et al. Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells , 2019, Journal of Experimental & Clinical Cancer Research.
[22] Xiaoyu Chen,et al. The role of m6A RNA methylation in human cancer , 2019, Molecular cancer.
[23] J. Kocerha,et al. The Potential for microRNA Therapeutics and Clinical Research , 2019, Front. Genet..
[24] Hanno Meyer,et al. Resolving the controls of water vapour isotopes in the Atlantic sector , 2019, Nature Communications.
[25] T. Guo,et al. The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1 , 2019, Neurochemistry International.
[26] N. Senzer,et al. Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy , 2019, Future science OA.
[27] L. Weiner,et al. Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy , 2019, International journal of molecular sciences.
[28] Jianjun Chen,et al. IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner , 2018, Nucleic acids research.
[29] Shicheng Guo,et al. Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma , 2018, Cell Death & Disease.
[30] V. Trochon-Joseph,et al. Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model , 2018, Cancer Immunology, Immunotherapy.
[31] Yan Ding,et al. Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis , 2018, Nature Communications.
[32] A. Ciarrocchi,et al. BRD4 and Cancer: going beyond transcriptional regulation , 2018, Molecular Cancer.
[33] C. Elmets,et al. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial. , 2018, The Lancet. Oncology.
[34] H. Wood. FDA approves patisiran to treat hereditary transthyretin amyloidosis , 2018, Nature Reviews Neurology.
[35] S. M. Toor,et al. DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer , 2018, Clinical Epigenetics.
[36] Hao Qu,et al. Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma. , 2018, Cancer research.
[37] G. Freeman,et al. LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade , 2018, Cell.
[38] B. Ali,et al. DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer , 2018, Clinical Epigenetics.
[39] Yiping Li,et al. DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer , 2018, Oncogene.
[40] B. V. Van Ness,et al. EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes , 2018, Oncotarget.
[41] S. Kubota,et al. Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells , 2018, Bioscience, biotechnology, and biochemistry.
[42] P. Ma,et al. Multiple functions of m6A RNA methylation in cancer , 2018, Journal of Hematology & Oncology.
[43] Y. Lou,et al. Next generation of immune checkpoint therapy in cancer: new developments and challenges , 2018, Journal of Hematology & Oncology.
[44] D. Spector,et al. Therapeutic Targeting of Long Non-Coding RNAs in Cancer. , 2018, Trends in molecular medicine.
[45] W. Béguelin,et al. Enhancer of zeste homolog 2 (EZH2) inhibitors , 2018, Leukemia & lymphoma.
[46] C. Zahnow,et al. DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer , 2018, Nature Communications.
[47] H. Döhner,et al. Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens , 2017, BMC Cancer.
[48] Samie R Jaffrey,et al. Rethinking m6A Readers, Writers, and Erasers. , 2017, Annual review of cell and developmental biology.
[49] D. Bailey,et al. Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. , 2017, The Lancet. Oncology.
[50] S. K. Zaidi,et al. Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer , 2017, Molecular and Cellular Biology.
[51] G. Castellani,et al. RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN , 2017, Nucleic acids research.
[52] E. Thiel,et al. Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia , 2017, Haematologica.
[53] Paul G. Thomas,et al. De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation , 2017, Cell.
[54] Elizabeth T. Wiles,et al. H3K27 methylation: a promiscuous repressive chromatin mark. , 2017, Current opinion in genetics & development.
[55] M. D’Incalci,et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus , 2016, Oncotarget.
[56] Nathan Archer,et al. m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination , 2016, Nature.
[57] H. Einsele,et al. The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective , 2016, Advances in Therapy.
[58] Benjamin G. Bitler,et al. BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. , 2016, Cell reports.
[59] Bryan J. Venters,et al. High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. , 2016, Cell reports.
[60] G. Gerken,et al. Resminostat plus sorafenib as second-line therapy of advanced hepatocellular carcinoma - The SHELTER study. , 2016, Journal of hepatology.
[61] S. Gupta,et al. Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells , 2016, Prostate Cancer and Prostatic Diseases.
[62] T. Preiss,et al. METTL3 Gains R/W Access to the Epitranscriptome. , 2016, Molecular cell.
[63] H. Dombret,et al. Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study. , 2016, The Lancet. Haematology.
[64] G. Stein,et al. Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri‐Methylation as a Biomarker for Phenotypic Plasticity , 2016, Journal of cellular physiology.
[65] Min Gyu Lee,et al. An essential role for UTX in resolution and activation of bivalent promoters , 2016, Nucleic acids research.
[66] J. Bradner,et al. The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects , 2016, Clinical Cancer Research.
[67] Arne Klungland,et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation , 2015, Genes & development.
[68] Łukasz M. Boryń,et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition , 2015, Nature.
[69] Kathleen R. Cho,et al. Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy , 2015, Nature.
[70] L. Ouafik,et al. Abstract 2625: Targeting prostate cancer stem cells (CSCs) with the novel BET bromodomain (BRD) protein inhibitor OTX015 , 2015 .
[71] G. Wang,et al. Targeting EZH2 and PRC2 dependence as novel anticancer therapy. , 2015, Experimental hematology.
[72] M. Dimopoulos,et al. Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma , 2015, Expert review of anticancer therapy.
[73] Manel Esteller,et al. RNA-RNA interactions in gene regulation: the coding and noncoding players. , 2015, Trends in biochemical sciences.
[74] S. Tavazoie,et al. N6-methyladenosine marks primary microRNAs for processing , 2015, Nature.
[75] O. Bernard,et al. TET proteins and the control of cytosine demethylation in cancer , 2015, Genome Medicine.
[76] Xiuheng Liu,et al. Relationship between LSD1 expression and E-cadherin expression in prostate cancer , 2015, International Urology and Nephrology.
[77] Karim Benkirane,et al. Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors , 2015, Genome Medicine.
[78] Takayoshi Suzuki,et al. NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect , 2014, Oncotarget.
[79] R. Weinberg,et al. How does multistep tumorigenesis really proceed? , 2015, Cancer discovery.
[80] L. van Doorn,et al. In Vitro Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122 , 2014, Antimicrobial Agents and Chemotherapy.
[81] M. Aftab,et al. Long noncoding RNAs as putative biomarkers for prostate cancer detection. , 2014, The Journal of molecular diagnostics : JMD.
[82] L. Chung,et al. Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis , 2014, Oncogene.
[83] Schraga Schwartz,et al. Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. , 2014, Cell reports.
[84] David A. Drew,et al. Loss of the polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors. , 2014, Cancer research.
[85] M. Hollingshead,et al. Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine , 2014, Cancer Chemotherapy and Pharmacology.
[86] S. Baylin,et al. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. , 2014, Molecular cell.
[87] A. Jimeno,et al. Belinostat for the treatment of peripheral T-cell lymphomas. , 2014, Drugs of today.
[88] N. Sharpless,et al. Detecting and characterizing circular RNAs , 2014, Nature Biotechnology.
[89] Samir Adhikari,et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase , 2014, Cell Research.
[90] Miao Yu,et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation , 2013, Nature chemical biology.
[91] H. Kantarjian,et al. Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics , 2014, BMC Cancer.
[92] J. Issa,et al. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition , 2013, Genome Biology.
[93] R. Johnstone,et al. An intact immune system is required for the anticancer activities of histone deacetylase inhibitors. , 2013, Cancer research.
[94] G. Ganji,et al. BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models , 2013, PloS one.
[95] Hongbo Zhao,et al. Tet family of 5-methylcytosine dioxygenases in mammalian development , 2013, Journal of Human Genetics.
[96] Bohuslav Melichar,et al. Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[97] Tim J. Wigle,et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 , 2013, Proceedings of the National Academy of Sciences.
[98] David A. Orlando,et al. Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.
[99] D. Spector,et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. , 2013, Cancer research.
[100] Arne Klungland,et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. , 2013, Molecular cell.
[101] W. Zhou,et al. The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. , 2013, Biochemical and biophysical research communications.
[102] Giacomo Cavalli. EZH2 Goes Solo , 2012, Science.
[103] J. Whetstine,et al. Histone lysine methylation dynamics: establishment, regulation, and biological impact. , 2012, Molecular cell.
[104] H. Varmus,et al. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins , 2012, Proceedings of the National Academy of Sciences.
[105] Christopher J. Ott,et al. BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. , 2012, Blood.
[106] Robert Brown,et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling , 2012, Oncogene.
[107] H. Manev,et al. Effect of valproic acid on mitochondrial epigenetics. , 2012, European journal of pharmacology.
[108] Z. Estrov,et al. Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis. , 2012, Leukemia research.
[109] Nadav S. Bar,et al. Landscape of transcription in human cells , 2012, Nature.
[110] M. Ahn,et al. Randomized phase II trial of first-line treatment with pemetrexed-cisplatin, followed sequentially by gefitinib or pemetrexed, in East Asian, never-smoker patients with advanced non-small cell lung cancer. , 2012, Lung cancer.
[111] O. Elemento,et al. Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons , 2012, Cell.
[112] S. Friedman,et al. Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. , 2012, Journal of hepatology.
[113] F. Hirsch,et al. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[114] S. Bates,et al. Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma. , 2012, Clinical journal of oncology nursing.
[115] J. Finsterer,et al. Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders , 2012, Expert opinion on drug metabolism & toxicology.
[116] A. Ferrando,et al. Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia , 2011, Nature Medicine.
[117] M. Esteller,et al. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis , 2011, Oncogene.
[118] E. Buckles,et al. Aberrant DNA Methylation and Prostate Cancer , 2011, Current genomics.
[119] Chengqi Yi,et al. N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO , 2011, Nature chemical biology.
[120] J. Hainsworth,et al. A Phase II Trial of Panobinostat, a Histone Deacetylase Inhibitor, in the Treatment of Patients with Refractory Metastatic Renal Cell Carcinoma , 2011, Cancer investigation.
[121] G. Giaccone,et al. Phase II study of belinostat in patients with recurrent or refractory advanced thymic epithelial tumors. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[122] Jørgen Kjems,et al. Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer , 2011, International journal of cancer.
[123] A. Chase,et al. Aberrations of EZH2 in Cancer , 2011, Clinical Cancer Research.
[124] O. Elemento,et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. , 2010, Blood.
[125] Peter A. Jones,et al. Targeting DNA methylation for epigenetic therapy. , 2010, Trends in pharmacological sciences.
[126] Xiong Cai,et al. CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity. , 2010, Cancer research.
[127] H. Dombret,et al. Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome , 2010, Oncotarget.
[128] Martha R. Stampfer,et al. Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells , 2010, PloS one.
[129] Kurt Zatloukal,et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo , 2010, Molecular Cancer.
[130] Lee E. Edsall,et al. Human DNA methylomes at base resolution show widespread epigenomic differences , 2009, Nature.
[131] M. Schaefer,et al. Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. , 2009, Cancer research.
[132] Quan-sheng Zhu,et al. Combining PCI-24781, a Novel Histone Deacetylase Inhibitor, with Chemotherapy for the Treatment of Soft Tissue Sarcoma , 2009, Clinical Cancer Research.
[133] L. Borsu,et al. Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. , 2009, Cancer research.
[134] C. Burge,et al. Most mammalian mRNAs are conserved targets of microRNAs. , 2008, Genome research.
[135] K. Robertson,et al. DNA methylation in development and human disease. , 2008, Mutation research.
[136] Guo-Cheng Yuan,et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. , 2008, Molecular cell.
[137] B. Ren,et al. Role of the Histone H3 Lysine 4 Methyltransferase, SET7/9, in the Regulation of NF-κB-dependent Inflammatory Genes , 2008, Journal of Biological Chemistry.
[138] F. Lyko,et al. Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine , 2008, International journal of cancer.
[139] G. Peters,et al. CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. , 2008, Oncology reports.
[140] G. Goodall,et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 , 2008, Nature Cell Biology.
[141] Sun-Mi Park,et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. , 2008, Genes & development.
[142] Qian Tao,et al. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. , 2008, Human molecular genetics.
[143] Stefan Offermanns,et al. Encyclopedia of Molecular Pharmacology , 2008 .
[144] R. Amato. Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy. , 2007, Clinical genitourinary cancer.
[145] Richard Pazdur,et al. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. , 2007, The oncologist.
[146] S. Spivack,et al. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. , 2007, Cancer research.
[147] O. Politz,et al. MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent. , 2007, The international journal of biochemistry & cell biology.
[148] Adrian Bird,et al. Perceptions of epigenetics , 2007, Nature.
[149] Dustin E. Schones,et al. High-Resolution Profiling of Histone Methylations in the Human Genome , 2007, Cell.
[150] F. Lyko,et al. Methylation of Human MicroRNA Genes in Normal and Neoplastic Cells , 2007, Cell cycle.
[151] M. Szyf,et al. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. , 2007, Carcinogenesis.
[152] C. Pérez-Plasencia,et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors , 2007, BMC Cancer.
[153] F. Forneris,et al. A Highly Specific Mechanism of Histone H3-K4 Recognition by Histone Demethylase LSD1* , 2006, Journal of Biological Chemistry.
[154] Yi Zhang,et al. JmjC-domain-containing proteins and histone demethylation , 2006, Nature Reviews Genetics.
[155] Alessandra Marini,et al. Epigenetic silencing of the PTEN gene in melanoma. , 2006, Cancer research.
[156] Z. Cao,et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo , 2006, Molecular Cancer Therapeutics.
[157] James A. Cuff,et al. A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells , 2006, Cell.
[158] John M Bennett,et al. Decitabine improves patient outcomes in myelodysplastic syndromes , 2006, Cancer.
[159] R. Reinhardt,et al. Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase , 2006, Nucleic acids research.
[160] H. Erdjument-Bromage,et al. Histone demethylation by a family of JmjC domain-containing proteins , 2006, Nature.
[161] A. Mirmohammadsadegh,et al. Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. , 2006, The Journal of investigative dermatology.
[162] K. Robertson. DNA methylation and human disease , 2005, Nature Reviews Genetics.
[163] Alexander V. Lyubimov,et al. Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine , 2005, Clinical Cancer Research.
[164] Gangning Liang,et al. Preferential response of cancer cells to zebularine. , 2004, Cancer cell.
[165] Peter A. Jones,et al. Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.
[166] Peter A. Jones,et al. Continuous Zebularine Treatment Effectively Sustains Demethylation in Human Bladder Cancer Cells , 2004, Molecular and Cellular Biology.
[167] E. Eisenhauer,et al. A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.
[168] M. Grever,et al. Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood. , 2003, Rapid communications in mass spectrometry : RCM.
[169] V. Pirrotta,et al. Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites , 2002, Cell.
[170] Brigitte Wild,et al. Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex , 2002, Cell.
[171] Hengbin Wang,et al. Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing , 2002, Science.
[172] Minoru Yoshida,et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. , 2002, Cancer research.
[173] Lei Zhou,et al. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. , 2002, Journal of molecular biology.
[174] Peter A. Jones,et al. The fundamental role of epigenetic events in cancer , 2002, Nature Reviews Genetics.
[175] J. Holland,et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[176] Gangning Liang,et al. Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements , 2002, Molecular and Cellular Biology.
[177] T. Mahmoudi,et al. Chromatin silencing and activation by Polycomb and trithorax group proteins , 2001, Oncogene.
[178] R. Jaenisch,et al. Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase. , 1997, Nucleic acids research.
[179] S. Kato,et al. Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. , 1991, Journal of medicinal chemistry.
[180] A. Bird. CpG-rich islands and the function of DNA methylation , 1986, Nature.
[181] C. Waddington. The evolution of an evolutionist , 1975 .