Apparent ketoconazole failure in candidal cholecystitis.

Fungal acalculous cholecystitis is a rarely recognized complication of disseminated candidal infections. We report such a case of systemic candidiasis that developed in a man who was diabetic while he was receiving broad-spectrum antibiotic therapy for an infected foot ulcer. Ketoconazole, a new imidazole antifungal agent, was used successfully to treat the systemic candidal infection but it failed to eradicate the fungus in the biliary tract.

[1]  P. Hermanek.  Zur Mykologie der Galle bzw. Gallenblase , 1965, Langenbecks Archiv für klinische Chirurgie.

[2]  W. Hughes.  Systemic candidiasis: a study of 109 fatal cases. , 1982, Pediatric infectious disease.

[3]  D. Alling,et al.  Treatment of chronic mucocutaneous candidosis with ketoconazole: preliminary results of a controlled, double-blind clinical trial. , 1980, Reviews of infectious diseases.

[4]  T. Ludden,et al.  Excretion pathways of amphotericin B. , 1979, The Journal of infectious diseases.

[5]  C. Magnussen,et al.  Candida fungus balls in the common bile duct. Unusual manifestation of disseminated candidiasis. , 1979, Archives of internal medicine.

[6]  E. Stiehm,et al.  Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy. , 1978, Annals of internal medicine.

[7]  D. Heimbach,et al.  Acalculous cholecystitis in critically ill patients. , 1978, American journal of surgery.

[8]  D. Armstrong,et al.  Common bile duct obstruction secondary to infection with Candida , 1978, Journal of clinical microbiology.

[9]  D. D. Miller.  Postoperative acalculous cholecystitis due to Torulopsis glabrata. , 1976, Archives of surgery.

[10]  J. Edwards,et al.  Experimental hematogenous endophthalmitis caused by Candida albicans. , 1975, The Journal of infectious diseases.

[11]  J. Edwards,et al.  OCULAR MANIFESTATIONS OF CANDIDA SEPTICEMIA: REVIEW OF SEVENTY-SIX CASES OF HEMATOGENOUS CANDIDA ENDOPHTHALMITIS , 1974, Medicine.

[12]  P. Sherlock,et al.  Candida infection of the gastrointestinal tract. , 1972, Medicine.

[13]  J. Duval,et al.  [Evolutive chronic polyarthritis. Tetanus, septicemia and cholecystitis caused by Candida. 2 months of intensive care followed by cure]. , 1971, Annales de medecine interne.