Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding

[1]  A. Dart,et al.  Regulation of glycosaminoglycan structure and atherogenesis , 2004, Cellular and Molecular Life Sciences CMLS.

[2]  L. Suzuki,et al.  Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells , 2003, Diabetologia.

[3]  William A. Boisvert,et al.  Transcriptional Repression of Atherogenic Inflammation: Modulation by PPARδ , 2003, Science.

[4]  J. Plutzky.  PPARs as Therapeutic Targets: Reverse Cardiology? , 2003, Science.

[5]  G. Jennings,et al.  Inhibitory Activity of Clinical Thiazolidinedione Peroxisome Proliferator Activating Receptor-&ggr; Ligands Toward Internal Mammary Artery, Radial Artery, and Saphenous Vein Smooth Muscle Cell Proliferation , 2003, Circulation.

[6]  E. Fleck,et al.  A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. , 2003, European journal of pharmacology.

[7]  T. Warner,et al.  Intimal Smooth Muscle Cells as a Target for Peroxisome Proliferator-Activated Receptor-&ggr; Ligand Therapy , 2002, Circulation research.

[8]  S. Haffner,et al.  Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus , 2002, Circulation.

[9]  B. Staels,et al.  Cardiovascular biology: A cholesterol tether , 2002, Nature.

[10]  J. Borén,et al.  Subendothelial retention of atherogenic lipoproteins in early atherosclerosis , 2002, Nature.

[11]  P. Little,et al.  Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. , 2002, Atherosclerosis.

[12]  A. Chait,et al.  Proteoglycans Synthesized by Arterial Smooth Muscle Cells in the Presence of Transforming Growth Factor‐&bgr;1 Exhibit Increased Binding to LDLs , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[13]  G. Jennings,et al.  Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor. , 2001, American journal of hypertension.

[14]  M. Salmivirta,et al.  Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance. , 2001, Diabetes.

[15]  P. Vijayagopal,et al.  Effect of calcium channel blockers on proteoglycan synthesis by vascular smooth muscle cells and low density lipoprotein--proteoglycan interaction. , 2001, Atherosclerosis.

[16]  D Heinegård,et al.  The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis. , 2001, Archives of biochemistry and biophysics.

[17]  W. Wilkison,et al.  Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. , 2001, Bioorganic & medicinal chemistry letters.

[18]  Diabetes Atherosclerosis Intervention Study Investigators.  Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study , 2001, The Lancet.

[19]  W. Hsueh,et al.  Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Retinoblastoma Phosphorylation and G1 → S Transition in Vascular Smooth Muscle Cells* , 2000, The Journal of Biological Chemistry.

[20]  R. Midura,et al.  Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore-assisted carbohydrate electrophoresis (FACE). , 2000, Glycobiology.

[21]  R. Midura,et al.  Adaptation of FACE methodology for microanalysis of total hyaluronan and chondroitin sulfate composition from cartilage. , 2000, Glycobiology.

[22]  A. Chait,et al.  Oxidized Low Density Lipoproteins Regulate Synthesis of Monkey Aortic Smooth Muscle Cell Proteoglycans That Have Enhanced Native Low Density Lipoprotein Binding Properties* , 2000, The Journal of Biological Chemistry.

[23]  R. Ross.  Atherosclerosis is an inflammatory disease , 1999 .

[24]  T. Wilt,et al.  Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. , 1999, The New England journal of medicine.

[25]  G. Bondjers,et al.  Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins. , 1999, Diabetes.

[26]  K. Williams,et al.  The response-to-retention hypothesis of atherogenesis reinforced. , 1998, Current opinion in lipidology.

[27]  W. Koenig,et al.  Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators , 1998, Nature.

[28]  G. Bondjers,et al.  Insoluble complex formation between LDL and arterial proteoglycans in relation to serum lipid levels and effects of lipid lowering drugs. , 1996, Atherosclerosis.

[29]  K. Williams,et al.  The response-to-retention hypothesis of early atherogenesis. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[30]  G. Bondjers,et al.  Binding of low density lipoproteins by proteoglycans synthesized by proliferating and quiescent human arterial smooth muscle cells. , 1993, The Journal of biological chemistry.

[31]  E. Schönherr,et al.  Platelet-derived growth factor and transforming growth factor-beta 1 differentially affect the synthesis of biglycan and decorin by monkey arterial smooth muscle cells. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[32]  G. Torri,et al.  A comparative study of low-density lipoprotein interaction with glycosaminoglycans. , 1993, Biochimica et biophysica acta.

[33]  E. Schönherr,et al.  Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells. , 1991, The Journal of biological chemistry.

[34]  P. Little,et al.  Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism. , 1990, Circulation research.

[35]  H. Kresse,et al.  Influence of chlorate on proteoglycan biosynthesis by cultured human fibroblasts. , 1988, Journal of Biological Chemistry.

[36]  A. Chait,et al.  Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. , 1986, The Journal of clinical investigation.

[37]  A. Malmström,et al.  Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues. , 1975, The Journal of biological chemistry.

[38]  J. Plutzky.  Medicine. PPARs as therapeutic targets: reverse cardiology? , 2003, Science.

[39]  A. Mokdad,et al.  Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. , 2003, JAMA.

[40]  A. Chait,et al.  Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL. , 2002, Journal of lipid research.

[41]  R. Evans,et al.  PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation , 2001, Nature Medicine.

[42]  Ames,et al.  Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. , 1999, The New England journal of medicine.

[43]  W. Hsueh,et al.  Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells. , 2000, The Journal of biological chemistry.

[44]  W. Koenig,et al.  Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators. , 1998, Nature.

[45]  P. A. Mourão,et al.  Glycosaminoglycan fractions from human arteries presenting diverse susceptibilities to atherosclerosis have different binding affinities to plasma LDL. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[46]  A. Chait.  Pathogenesis of macrovascular disease in diabetes. , 1994 .

[47]  Å. Wasteson.  A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate. , 1971, Journal of chromatography.